Lotrel, Hyzaar, and More: 12 Combination Blood Pressure Medications (Plus Ways to Save)

Having to take several blood pressure medications every day can be a hassle. If you’re stable on your current medications, you may be able to combine them into one pill.

For some people, combination blood pressure medications can offer convenience and make it easier to stay on track with your treatment plan. But combination pills aren’t right for everyone. So it may be worth talking about your options with your healthcare provider.

What are the different classifications of combination blood pressure medications?

There are many different combination blood pressure medications available. They most often contain a combination of the following medication classes, which can work together in different ways to lower your blood pressure.

Common examples of combination blood pressure medications include:

• ACE Inhibitor / CCB

• ACE inhibitor / thiazide diuretic

• ARB / thiazide diuretic

• Beta blocker / thiazide diuretic

• Beta blocker / thiazide-like diuretic

• CCB / ARB

• CCB / ARB / thiazide diuretic

Which combination you’re prescribed can depend on your health history, treatment goals, and other factors. 

If you’re taking at least two of the medication classes above, it may be worth seeing if they’re available together in one pill.

1. Zestoretic

Zestoretic is a combination of lisinopril (Zestril) and hydrochlorothiazide (called HCTZ for short). Lisinopril is a popular ACE inhibitor, and HCTZ is a thiazide diuretic. Zestoretic is available in the following tablet dosages (as lisinopril/HCTZ):

• 10 mg/12.5 mg

• 20 mg/12.5 mg

• 20 mg/25 mg

The generic version of Zestoretic costs as little as $13.56 at certain pharmacies with a GoodRx coupon.

2. Lotensin HCT

Lotensin HCT is a combination of HCTZ and a different ACE inhibitor, benazepril (Lotensin). Lotensin HCT is available in the following tablet dosages (as benazepril/HCTZ):

• 5 mg/6.25 mg

• 10 mg/12.5 mg

• 20 mg/12.5 mg

• 20 mg/25 mg

With GoodRx, prices for generic Lotensin HCT may be as low as $36.15.

3. Vaseretic

Vaseretic is the last ACE inhibitor/diuretic combination we’ll cover on this list. In addition to HCTZ, it contains the ACE inhibitor enalapril (Vasotec). Vaseretic is available in the following tablet dosages (as enalapril/HCT):

• 5 mg/12.5 mg

• 10 mg/25 mg

Generic Vaseretic is available at certain pharmacies for as low as $27.24 with GoodRx.

4. Micardis HCT

Micardis HCT is a combination of HCTZ with telmisartan (Micardis), an ARB. Micardis HCT is available in the following tablet dosages (as telmisartan/HCTZ):

• 40 mg/12.5 mg

• 80 mg/12.5 mg

• 80 mg/25 mg

The price of generic Micardis HCT is as low as $24.00 at certain pharmacies with GoodRx.

5. Hyzaar

Hyzaar is a combination of HCTZ with a different ARB called losartan (Cozaar). Hyzaar is available in the following tablet dosages (as losartan/HCTZ):

• 50 mg/12.5 mg

• 100 mg/12.5 mg

• 100 mg/ 25 mg

With GoodRx, the price of generic Hyzaar is as low as $11.68 at certain pharmacies.

6. Diovan HCT

Diovan HCT is another ARB/diuretic combination. It contains HCTZ and the ARB valsartan (Diovan). Diovan HCT is available in the following tablet dosages (as valsartan/HCTZ):

• 80 mg/12.5 mg

• 160 mg/12.5 mg

• 160 mg/25 mg

• 320 mg/12.5 mg

• 320 mg/25 mg

Generic Diovan HCT tablets cost as little as $16.80 with GoodRx. If you’re eligible, you could pay as little as $10 for the brand-name version with a manufacturer copay savings card.

7. Benicar HCT

Benicar HCT is also an ARB/diuretic combination with HCTZ. But in this case, the ARB is olmesartan (Benicar). Benicar HCT is available in the following tablet dosages (as olmesartan/HCTZ):

• 20 mg/12.5 mg

• 40 mg/12.5 mg

• 40 mg/25 mg

The price of generic Benicar HCT is as low as $17.51 with GoodRx. The manufacturer also offers a copay savings card for the brand-name version. If you’re eligible, you could pay as little as $5 per month.

8. Atacand HCT

Atacand HCT is the last ARB/diuretic combination on this list. Along with HCTZ, it contains the ARB candesartan (Atacand). Atacand HCT is available in the following tablet dosages (as candesartan/HCTZ):

• 16 mg/12.5 mg

• 32 mg/12.5 mg

• 32 mg/25 mg

With GoodRx, generic Atacand HCT costs as little as $.

9. Exforge

Exforge is a combination of valsartan (an ARB) and a CCB called amlodipine (Norvasc). Exforge is available in the following tablet dosages (as amlodipine/valsartan):

• 5 mg/160 mg

• 5 mg/320 mg

• 10 mg/160 mg

• 10 mg/320 mg

If you’re also taking hydrochlorothiazide, Exforge HCT may be another option. It’s a combination of three medications: amlodipine, valsartan, and HCTZ. Exforge HCT is available in the following tablet dosages (as amlodipine/valsartan/HCTZ):

• 5 mg/160 mg/12.5 mg

• 5 mg/160 mg/25 mg

• 10 mg/160 mg/12.5 mg

• 10 mg/160 mg/25 mg

• 10 mg/320 mg/25 mg

With GoodRx, you could pay as little as $24.90 for generic Exforge. Generic Exforge HCT’s price is as low as $99.93.

10. Lotrel

Lotrel contains amlodipine (a CCB) and the ACE inhibitor benazepril. Unlike Exforge, this combination isn’t also available with HCTZ. Lotrel is available in the following tablet dosages (as amlodipine/benazepril):

• 2.5 mg/10 mg

• 5 mg/10 mg

• 5 mg/20 mg

• 5 mg/40 mg

• 10 mg/20 mg

• 10 mg/40 mg

Generic Lotrel’s price is as low as $8.70 with GoodRx. 

11. Ziac

Ziac (bisoprolol/hydrochlorothiazide) is a combination of HCTZ and bisoprolol, a beta blocker. Ziac contains a fixed amount of HCTZ in each tablet: 6.25 mg. The amounts of bisoprolol can vary:

• 2.5 mg/6.25 mg

• 5 mg/6.25 mg

• 10 mg/ 6.25 mg

With GoodRx, you could pay as little as $17.76 for generic Ziac at certain pharmacies.

12. Tenoretic

Tenoretic is another beta blocker/diuretic combination. It combines the beta blocker atenolol (Tenormin) with chlorthalidone (Thalitone), a thiazide-like diuretic. Chlorthalidone is similar to HCTZ, but it tends to last longer in the body. Tenoretic is available in the following tablet dosages (as atenolol/chlorthalidone):

• 50 mg/25 mg

• 100 mg/25 mg

Generic Tenoretic’s price is as low as $39.64 with GoodRx.

Who can benefit from combination blood pressure medications?

Combination blood pressure medications aren’t right for everyone. But they can be a good option for certain people. Here are a few things to consider if you’re thinking about using these medications:

• Are your medications and doses available as a combination pill? Many popular blood pressure medications come in single-pill combinations — but not all of them. And the doses you’re taking might be different from what’s available in combination pills, too.

• Are you stable on your current medications and doses? If you’re still figuring out the right medication and/or dose, a combination pill might not be the best choice. But if you’ve been taking the same regimen for a while, it may be an option to consider.

• Are you having difficulty taking your pills on time? A combination pill can help reduce the number of pills you take every day. Fewer pills can help simplify your routine and make it easier to remember when to take your medication.

• Are your medication costs adding up? Most blood pressure medications are available as lower-cost generics, but the cost of multiple prescriptions can be pricey. Sometimes, you may be able to save money with a combination blood pressure pill instead.

If you’ve been taking at least two blood pressure medications for a while, discuss your options with your healthcare provider or pharmacist. A combination blood pressure medication may be a good fit.

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Written by:

Timothy Aungst, PharmD

Timothy Aungst, PharmD, has worked in pharmacy practice for the past decade with different roles and responsibilities. He has served as an associate professor of pharmacy practice for almost a decade, a clinical pharmacist in outpatient cardiology management, and now in home healthcare.

Edited by:

Alyssa Billingsley, PharmD

Alyssa Billingsley, PharmD, is the director of pharmacy content for GoodRx. She has over a decade of experience as a pharmacist and has worked in clinical, academic, and administrative roles.

Reviewed by:

Tegan Smedley, PharmD, APh

Tegan Smedley, PharmD, APh, has 10 years of experience as a pharmacist. She has worked in a variety of settings, including retail, hospital, and ambulatory care.

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