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Amlodipine / Benazepril Coupon - Amlodipine / Benazepril 10mg/40mg capsule

amlodipine / benazepril

Generic Lotrel
Used for Hypertension
Used for Hypertension

Lotrel (amlodipine / benazepril) combines two first-choice medications to lower your blood pressure. In addition, it helps lower your risk for heart attack, stroke, and heart failure. But to get the most out of the medication, you're encouraged to maintain a healthy diet and regular exercise routine. Lotrel (amlodipine / benazepril) is taken by mouth, typically once daily. It's available as a lower-cost generic.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Connie Zheng, PharmD
Last reviewed on March 6, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Lotrel (amlodipine / benazepril)?

What is Lotrel (amlodipine / benazepril) used for?

  • High blood pressure

How Lotrel (amlodipine / benazepril) works

Lotrel (amlodipine / benazepril) is a combination of two medications that work together to lower blood pressure.

  • Amlodipine is a calcium channel blocker (CCB). It works by relaxing your blood vessels to lower your blood pressure.

  • Benazepril is an angiotensin-converting enzyme (ACE) inhibitor. It relaxes your blood vessels by blocking the ACE protein that typically squeezes your blood vessels.

When does Lotrel (amlodipine / benazepril) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsLotrel
Drug ClassCCB / ACE inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Avg retail price
$122.520
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$122.52
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What are the side effects of Lotrel (amlodipine / benazepril)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Cough (3%)
  • Headache (2%)
  • Swelling in the hands and feet (2%)
  • Dizziness (1%)

Other Side Effects

  • Rash
  • Reddening of skin (flushing)
  • Sleepiness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Angioedema (severe swelling): swelling of the face, arms or legs, lips, tongue, or throat
  • Heart attack: tightness and pain in the chest, neck, arms, or back; cold and clammy skin; sweating; dizziness; tiredness
  • Serious kidney problems: urinating less often than usual, swelling in your feet, ankles, or hands, unexplained weight gain
  • High blood potassium levels: nausea, muscle weakness, tingling sensation, abnormal heartbeat
  • Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint or fainting
  • Severe liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
When do Lotrel (amlodipine / benazepril) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Dizziness
Cough
Swelling in the hands and feet
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Confusion

dizziness, lightheadedness, or fainting

fast or irregular heartbeat

nervousness

numbness or tingling in the hands, feet, or lips

swelling of the ankles, feet, or lower legs

weakness or heaviness of the legs

Rare

Bleeding gums

chills

fever

nausea or vomiting

nosebleeds

pale skin

sores, ulcers, or white spots on the lips, tongue, or inside the mouth

stomach pain or bloating with fever, nausea, or vomiting

swelling of the face, mouth, hands, or feet

trouble with swallowing or breathing (sudden) or hoarseness

unusual bleeding or bruising

unusual tiredness or weakness

yellow eyes or skin

Incidence not known

Chest pain

heartburn

pain or burning in the throat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Cough (dry and continuous)

feeling of warmth

redness of the face, neck, arms, and occasionally upper chest

sleepiness

Incidence not known

Belching

blistering, crusting, irritation, itching, or reddening of the skin

body aches or pain

cracked, dry, or scaly skin

decreased interest in sexual intercourse

difficulty having a bowel movement

frequent urination

inability to have or keep an erection

increased volume of pale, dilute urine

indigestion

lack or loss of strength

loss in sexual ability, desire, drive, or performance

muscle or bone pain

shakiness in the legs, arms, hands, or feet

stomach discomfort or upset

sudden sweating

swelling

tender, swollen glands in the neck

trembling or shaking of the hands or feet

trouble with sleeping

voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Lotrel (amlodipine / benazepril)

thumbs-up

Pros

Contains two first-choice medications for treating high blood pressure

Convenient to take a combination of two medications in one pill

Only taken once daily

Available as a lower-cost generic

thumbs-down

Cons

Not safe for pregnant or breastfeeding females

More difficult to customize the dose since Lotrel (amlodipine / benazepril) is a fixed combination of two medications

Can interact with commonly used medications, such as simvastatin (Zocor)

Can cause swelling in the arms and legs

pharmacist-tips

Pharmacist tips for Lotrel (amlodipine / benazepril)

pharmacist

  • Take Lotrel (amlodipine / benazepril) with or without food at any time of day.

    • Take Lotrel (amlodipine / benazepril) exactly as prescribed. Don't change your dose or suddenly stop taking the medication without talking to your provider first. Doing so can cause your blood pressure to rise quickly.

      • It's recommended that you check your blood pressure at home, record them, and bring your log to your medical appointments. Discuss with your provider about how well Lotrel (amlodipine / benazepril) is working for you. They can recommend any dose changes, if needed.

        • If you accidentally forget to take Lotrel (amlodipine / benazepril), take it as soon as you remember. But if the time you typically take your medication next is soon, then skip the missed dose. Never take two doses of Lotrel (amlodipine / benazepril) at the same time to make up any missed doses.

          • You might feel dizzy when you start taking Lotrel (amlodipine / benazepril) and when your provider raises your dose. This side effect should lessen over time as you continue taking the medication and your body gets used to your new blood pressure.

            • If you can, stand up slowly or hold onto something when you stand from a sitting or lying down position. This helps avoid a sudden drop in your blood pressure that can lead to dizziness and falling. If you feel dizzy, lightheaded, tired, or confused while taking Lotrel (amlodipine / benazepril), your blood pressure might be too low. Call your provider if this happens because your dose might need to be changed.

              • Some people experience swelling in their feet, ankles, legs, or hands when they take Lotrel (amlodipine / benazepril). Talk with your provider if you notice swelling or if the swelling becomes too bothersome. They might recommend tips to ease the swelling, such as sitting or lying down with your legs raised or wearing compression socks.

                • Having a healthy diet, including a low-salt diet, and regular exercise routine while taking Lotrel (amlodipine / benazepril) will further help lower your blood pressure.

                  • Try to limit foods high in potassium or limit using potassium-containing salt substitutes. Eating these types of foods with Lotrel (amlodipine / benazepril) might raise your potassium levels too much, which can lead to nausea, vomiting, or muscle weakness.

                    • It's best to avoid or limit how much alcohol you drink while taking Lotrel (amlodipine / benazepril). Depending on how much you drink, alcohol can cause a drop in your blood pressure, which can make you dizzy and cause you to fall.

                      • Lotrel (amlodipine / benazepril) interacts some common medications, such as simvastatin (Zocor) and non-steroidal anti-inflammatory (NSAIDS). Make sure to tell your provider about all of the medications you're taking before starting Lotrel (amlodipine / benazepril). Don't start any new medications while taking Lotrel (amlodipine / benazepril) without talking to your provider first.

                        • Make sure to mark your calendar with your appointments to see your provider and to get any blood work done when you take Lotrel (amlodipine / benazepril). Your provider might order tests (e.g., potassium level, kidney health, blood pressure) during treatment and might change your dose of Lotrel (amlodipine / benazepril) based on your lab results.

                          faqs

                          Frequently asked questions about Lotrel (amlodipine / benazepril)

                          Should I ask my provider about starting Lotrel (amlodipine / benazepril) if I was just diagnosed with high blood pressure?
                          It's unlikely that your provider will prescribe Lotrel (amlodipine / benazepril) for you if you've just been diagnosed with high blood pressure. Because Lotrel (amlodipine / benazepril) is a combination of two blood pressure medications, taking Lotrel (amlodipine / benazepril) can drop your blood pressure too low if you've never taken blood pressure medications before. Doing so can cause side effects such as dizziness or lightheadedness. Typically, providers prescribe Lotrel (amlodipine / benazepril) for people who've already been taking either amlodipine or benazepril (or similar medications), and might benefit from an additional blood pressure medication. Or, providers might prescribe Lotrel (amlodipine / benazepril) for people who want the convenience of taking a single pill after their blood pressure has been stable while taking amlodipine and benazepril separately. Ask your provider if you're not sure whether Lotrel (amlodipine / benazepril) is appropriate for you.
                          How do I know Lotrel (amlodipine / benazepril) is working for me?
                          Even though you can't directly feel the effects of blood pressure medications like Lotrel (amlodipine / benazepril), you can track how well they're working for you by checking your blood pressure regularly at home. Write down your blood pressure readings so you can review them with your provider and discuss how well Lotrel (amlodipine / benazepril) is working for you. Make sure to continue taking Lotrel (amlodipine / benazepril) even if you don't notice any improvements in your physical health. Managing your blood pressure helps prevent severe and life-threatening health problems, such as heart attack, stroke, and heart failure.
                          How long does it take for Lotrel (amlodipine / benazepril) to start working?
                          It can take about 2 weeks before you notice the full blood pressure-lowering effect from Lotrel (amlodipine / benazepril). Keep in mind that it can take some time before your provider finds a dose that works best for you. They might need to adjust your dose depending on your blood pressure reading or if you're having side effects. Make sure to be patient, continue taking Lotrel (amlodipine / benazepril), and follow up with your provider regularly.
                          Will Lotrel (amlodipine / benazepril) make me cough?
                          Dry cough is a well-known side effect of ACE-inhibitors, like benazepril. It's possible for you to get a cough from taking Lotrel (amlodipine / benazepril) at anytime during treatment. If you get a cough from Lotrel (amlodipine / benazepril) and it's bothersome, talk to your provider. They'll likely stop Lotrel (amlodipine / benazepril) and choose a different blood pressure medication that's much less likely to cause this side effect, such as an angiotensin II receptor blocker (ARB).
                          Can I take Lotrel (amlodipine / benazepril) if I'm pregnant?
                          No. Pregnant females shouldn't take Lotrel (amlodipine / benazepril) because it contains valsartan, which can cause severe harm to an unborn baby if taken during pregnancy. The medication can interfere with your unborn baby's kidney development and health, which can be life-threatening. If you're pregnant or thinking of getting pregnant, discuss with your provider about other treatments that might be safer during pregnancy.
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                          warings-icon

                          What are the risks and warnings for Lotrel (amlodipine / benazepril)?

                          Lotrel (amlodipine / benazepril) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                          risk-warning

                          Not for use during pregnancy

                          Lotrel (amlodipine / benazepril) shouldn't be taken during pregnancy because it can cause severe, and sometimes life-threatening harm, to unborn babies. Tell your provider before starting treatment if you're pregnant or thinking of becoming pregnant. They'll discuss with you about safer options to lower your blood pressure. If you find out that you're pregnant while taking Lotrel (amlodipine / benazepril), stop the medication and let your provider know right away.

                          risk-warning

                          Angioedema (swelling)

                          • Risk factors: Black people | Having angioedema in the past

                            People who take medications that contain an ACE inhibitor, like Lotrel (amlodipine / benazepril), can experience a rare, but serious side effect called angioedema. This involves swelling in different parts of the body, including the face, throat, and tongue. Swelling of the tongue or throat area can be potentially life-threatening, since it can make it difficult to breathe. Angioedema can happen at any time during treatment. This risk is higher in Black people than in non-Black people. Get medical attention immediately if you experience swelling in any of the areas mentioned above, stomach pain, or difficulty breathing. You'll have to stop taking Lotrel (amlodipine / benazepril) if this happens.

                            risk-warning

                            Low blood pressure

                            • Risk factors: Not enough fluid in your body | Having diarrhea or vomiting for a long time | Low salt levels in your body | Taking high doses of diuretic medications | History of narrow heart valves (aortic stenosis)

                              Lotrel (amlodipine / benazepril) can cause your blood pressure to drop too much, which can make you feel dizzy, tired, or lightheaded. This side effect is more common when you first start Lotrel (amlodipine / benazepril) or when the dose is raised. Make sure to stay well hydrated to avoid having blood pressure that's too low. If your blood pressure drops too much and you feel dizzy, sit down slowly while holding onto something and let your provider know. If you fall and hit your head, get medical help right away.

                              risk-warning

                              Risk of heart attack or chest pain

                              • Risk factors: Severe coronary artery disease

                                It's possible for some people to experience worsening chest pain or develop a heart attack while taking Lotrel (amlodipine / benazepril). The risk is higher when you first start this medication or when your dose is raised. Your risk is also higher if you have a heart problem called coronary artery disease (CAD). Get medical help right away if you experience chest pain, pressure in the chest, heartburn, dizziness, or trouble breathing.

                                risk-warning

                                Kidney damage

                                • Risk factors: Heart failure | Certain kidney problems | Taking other medications that can cause kidney damage

                                  Lotrel (amlodipine / benazepril) can affect your kidneys and cause them to not work as well. This is especially true in people with heart failure, current kidney problems, or people who take medications that can worsen kidney function. Your provider might order lab tests every so often to make sure your kidneys are healthy and working properly. If you develop kidney problems (or if your kidney problems worsen) while taking Lotrel (amlodipine / benazepril), your provider might recommend that you stop taking this medication. Let your provider know if you're urinating less often than usual, as this could be a sign that your kidneys aren't working as well.

                                  risk-warning

                                  High potassium levels

                                  • Risk factors: Taking other medications that can raise potassium levels | Heart failure | Kidney problems

                                    Lotrel (amlodipine / benazepril) can cause high potassium levels in the blood, even in people with healthy kidneys. Your risk is higher if you take other medications that can raise potassium, such as spironolactone (Aldactone). If you experience signs of high potassium levels, such as nausea, muscle weakness, or irregular heartbeat, tell your healthcare provider right away. They might want to measure your blood potassium level. If left untreated, high potassium levels can be dangerous.

                                    risk-warning

                                    Liver problems

                                    • Risk factors: History of liver problems | Drinking large amounts of alcohol

                                      Though rare, people who took Lotrel (amlodipine / benazepril) have experienced liver problems. Sometimes, this can be very serious. The reason for liver problems isn't clear. Get medical attention right away if you notice symptoms of liver problems, such as yellowing of your skin or the whites of your eyes, nausea, vomiting, or dark or brown urine. Your provider might ask you to stop taking Lotrel (amlodipine / benazepril) to prevent further liver damage.

                                      dosage

                                      Lotrel (amlodipine / benazepril) dosage forms

                                      The average cost for 30 capsules of 10mg/40mg of Lotrel (amlodipine / benazepril) is $1469.69 with a free GoodRx coupon. This is -138.41% off the average retail price of $616.47.
                                      capsule
                                      Capsule
                                      DosageQuantityPrice as low asPrice per unit
                                      5mg/10mg90 capsules$1066.97$11.86
                                      5mg/20mg30 capsules$385.80$12.86
                                      10mg/20mg30 capsules$461.04$15.37
                                      10mg/40mg90 capsules$1469.69$16.33

                                      Typical dosing for Lotrel (amlodipine / benazepril)

                                      • The typical starting dose is Lotrel 2.5 mg/10 mg (amlodipine/benazepril) by mouth once daily. Your provider will adjust your dose based on how well it's helping your blood pressure and if you're having side effects. The maximum dose is Lotrel 10 mg/40 mg (amlodipine/benazepril) once daily.

                                      interactions

                                      Interactions between Lotrel (amlodipine / benazepril) and other drugs

                                      Lotrel (amlodipine / benazepril) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Lotrel (amlodipine / benazepril). Please note that only the generic name of each medication is listed below.

                                      Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                      Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                      drug-cost

                                      How much does Lotrel (amlodipine / benazepril) cost?

                                      To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                                      Lotrel (brand)
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                                      $122.52

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                                      contraindications-icon

                                      Lotrel (amlodipine / benazepril) contraindications

                                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Lotrel (amlodipine / benazepril) will not be safe for you to take.
                                      alternatives

                                      What are alternatives to Lotrel (amlodipine / benazepril)?

                                      There are a number of medications that your doctor can prescribe in place of Lotrel (amlodipine / benazepril). Compare a few possible alternatives below.
                                      Lotrel (amlodipine / benazepril)
                                      Used for:

                                      • High blood pressure

                                      $122.52 Lowest GoodRx priceView Prices
                                      Telmisartan / amlodipine
                                      Used for:

                                      • High blood pressure

                                      $44.12 Lowest GoodRx priceView Prices
                                      Azor (amlodipine / olmesartan)
                                      Used for:
                                      $20.69 Lowest GoodRx priceView Prices
                                      images

                                      Lotrel (amlodipine / benazepril) images

                                      Blue Lotrel 0379 - Amlodipine Besylate / Benazepril Hydrochloride 10mg-40mg Capsule
                                      This medicine is Blue Capsule Imprinted With "Lotrel 0379".Blue Lotrel 0379 - Amlodipine Besylate / Benazepril Hydrochloride 10mg-40mg Capsule
                                      Purple And White Rdy 586 - Amlodipine Besylate / Benazepril Hydrochloride 10mg-40mg Capsule
                                      This medicine is Purple And White Capsule Imprinted With "Rdy 586".Purple And White Rdy 586 - Amlodipine Besylate / Benazepril Hydrochloride 10mg-40mg Capsule
                                      Blue J 03 - Amlodipine Besylate / Benazepril Hydrochloride 10mg-40mg Capsule
                                      This medicine is Blue Capsule Imprinted With "J 03".Blue J 03 - Amlodipine Besylate / Benazepril Hydrochloride 10mg-40mg Capsule
                                      Blue And White Lu E16 - Amlodipine Besylate / Benazepril Hydrochloride 10mg-40mg Capsule
                                      This medicine is Blue And White Capsule Imprinted With "Lu E16".Blue And White Lu E16 - Amlodipine Besylate / Benazepril Hydrochloride 10mg-40mg Capsule

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                                      References

                                      Best studies we found

                                      Cosette Pharmaceuticals, Inc. (2022). Understanding how AZOR (amlodipine and olmesartan medoxomil) works.

                                      Dr. Reddy's Laboratories Limited. (2022). AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE capsule [package insert]. DailyMed.

                                      Makani, H., et al. (2011). Peripheral edema associated with calcium channel blockers: incidence and withdrawal rate--a meta-analysis of randomized trials. Journal of Hypertension.

                                      View All References (1)

                                      Montford, J.R., et al. (2017). How dangerous is hyperkalemia? Journal of the American Society of Nephrology: JASN.

                                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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