7 Statin Alternatives You Can Take to Help Lower Your Cholesterol
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simvastatin
Used for Coronary Artery Disease, High Cholesterol
Used for Coronary Artery Disease, High Cholesterol
Simvastatin is a low-to-moderate intensity statin that helps lower cholesterol. This helps lower the risk of serious problems like heart attack or stroke. It's approved for adults and certain children 10 years and older. Simvastatin tablets are available as brand-name Zocor and a generic. The liquid suspension form only comes as brand-name FloLipid. The simvastatin dose is taken by mouth once each night. It works best when you also eat heart-healthy foods and stay active. Possible side effects are stomach pain, muscle pain, and headache.
What is Simvastatin?
What is Simvastatin used for?
- High cholesterol in adults
- High triglycerides in adults
- Homozygous familial hypercholesterolemia (HoFH) in adults
- Heterozygous familial hypercholesterolemia (HeFH) in people ages 10 years and older
- Lowering the risk of heart or blood vessel problems (e.g., heart attack, stroke) in adults at high risk
How Simvastatin works
Simvastatin is a statin. The main way it works is by blocking a protein in your liver that makes cholesterol. By blocking this protein, simvastatin affects different types of cholesterol and fats in the body.
- It lessens the amount of "bad" cholesterol in the blood. "Bad" cholesterol is also called low-density lipoprotein or LDL.
- It also lowers the amount of a type of fat in the blood called triglyceride.
- It helps raise the amount of "good" cholesterol a little bit in the body. "Good" cholesterol is also called high-density lipoprotein or HDL.
When does Simvastatin start working?Time passed since treatment started:
Drug facts
| Common Brands | Zocor, FloLipid |
|---|---|
| Drug Class | Statin |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
More on Simvastatin essentials
Side effects of Simvastatin
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Bronchitis (7%)
- Stomach pain (6%)
- Irregular heartbeat (6%)
- Inflamed stomach lining (nausea, vomiting, low appetite; 5%)
- Eczema (dry, itchy skin; 5%)
- Vertigo (dizzy, feeling like the room is spinning; 5%)
Less Common Side Effects
- Muscle pain
- Headache
- Constipation
- Swelling in hands, legs, or feet
- Inflamed sinuses
- Trouble sleeping
- Diabetes
- Urinary tract infection
Simvastatin serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe muscle damage (rhabdomyolysis): severe muscle weakness or pain, fever, tiredness, dark urine
- Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
When do Simvastatin possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Risk of muscle pain
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
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The following Simvastatin side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Dizziness
fainting
fast or irregular heartbeat
Less common
Bladder pain
bloody or cloudy urine
blurred vision
body aches or pain
chills
dark-colored urine
difficult, burning, or painful urination
difficulty with breathing
difficulty with moving
ear congestion
flushed, dry skin
frequent urge to urinate
fruit-like breath odor
headache
increased hunger
increased thirst
increased urination
joint pain
loss of consciousness
lower back or side pain
muscle cramps, spasms, stiffness, pain, tenderness, wasting, or weakness
runny or stuffy nose
stomachache
sweating
swelling
swollen joints
trouble breathing
unexplained weight loss
unusual tiredness or weakness
vomiting
Incidence not known
Blistering, peeling, or loosening of the skin
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
difficulty with swallowing
general tiredness and weakness
indigestion
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
loss of appetite
pains in the stomach, side, or abdomen, possibly radiating to the back
pale skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
red skin lesions, often with a purple center
red, irritated eyes
sores, ulcers, or white spots in the mouth or on the lips
tightness in the chest
unusual bleeding or bruising
upper right abdominal or stomach pain
weakness in the arms, hands, legs, or feet
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Acid or sour stomach
belching
burning feeling in the chest or stomach
dizziness or lightheadedness
excess air or gas in the stomach or intestines
feeling of constant movement of self or surroundings
full feeling
lack or loss of strength
pain or tenderness around the eyes and cheekbones
passing gas
sensation of spinning
skin rash, encrusted, scaly, and oozing
stomach discomfort, upset, or pain
tenderness in the stomach area
trouble sleeping
Incidence not known
Being forgetful
discoloration of the skin
hair loss or thinning of the hair
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$65.60
GoodRx discount
$9.07
Pros and cons of Simvastatin
Pros
Cons
- Has the highest risk among the statins to cause muscle pain
- Has some drug interactions, like with certain heart medications and grapefruit
- Can't take if you have certain liver problems
- Not recommended to take while pregnant or breastfeeding
Pharmacist tips for Simvastatin
- Take simvastatin once a day in the evening. Try to stick to the same time each night. This helps keep the medication working consistently. It can also help you remember to take it.
- If you miss a dose of simvastatin, take it as soon as you remember. Don't double up your next dose to make up for the missed dose because it could raise your risk of side effects.
- Take simvastatin tablets with or without food. If it's hurting your stomach, try taking it with food next time to help.
- Swallow simvastatin tablets whole. If you have trouble swallowing it, talk to your prescriber about your options.
- Avoid alcohol or limit how much you drink while taking simvastatin. Alcohol can raise your risk of serious liver problems with this medication. Talk to your prescriber about your drinking habits and how to stay safe while taking simvastatin.
- Avoid grapefruit or grapefruit juice while taking simvastatin. Grapefruit can raise the amount of the medication in your body and raise the risk of side effects.
- Tell your healthcare team about all the medications you take or plan to take (including vitamins and supplements). Simvastatin can interact with many common medications. For example, amiodarone (Pacerone), amlodipine (Norvasc), and colchicine can raise the level of simvastatin in your body. This can put you at higher risk of side effects, like muscle damage.
- Make sure to get all the blood tests your prescriber asks for while taking simvastatin. These tests help check your cholesterol levels to see how well the medication is working. Your prescriber might also check your liver to make sure the medication is still safe for you.
- You shouldn't take simvastatin if you're pregnant. Although still unclear, there's a possible risk of harm to an unborn baby. In most cases, it's still encouraged to stop taking statins while pregnant to be safe. Talk to your prescriber about the risks and benefits and the safest option for you.
- It's not recommended to breastfeed while taking simvastatin. There isn't enough information to know if it's safe. But some other statins can pass into breast milk and might harm a baby.
Tips for FloLipid, the oral liquid form of simvastatin:
- Take FloLipid (simvastatin) on an empty stomach. Studies show that food lowers how much of the liquid medication can get absorbed into your body.
- FloLipid (simvastatin) is available in two strengths: 20 mg/5 mL and 40 mg/5 mL. Make sure you know which strength you have and know how to correctly measure your prescribed dose.
- Shake the bottle of FloLipid (simvastatin) for at least 20 seconds before measuring your dose. Use an oral syringe or a dosing cup to measure out the medication. Don't use a household spoon to do this because it might not be accurate.
- Store FloLipid (simvastatin) at room temperature (68ºF to 77ºF). After you open the bottle, the medication is good for 30 days. Throw it away after 30 days, even if there's some medication left. The remaining medication might not work well anymore.
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Risks and warnings for Simvastatin
Simvastatin can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Severe muscle pain and damage
- Risk factors: Ages 65 years and older | Hypothyroidism that's not well-controlled | Kidney problems | Chinese descent | Taking a higher dose of simvastatin | Taking other medications that can also cause muscle problems | Taking medications that interact with simvastatin
Simvastatin can sometimes cause muscle pain or weakness. The risk is higher if you take other medications that cause muscle damage or interact with simvastatin.
In rare cases, simvastatin can cause a serious muscle problem called rhabdomyolysis. This can break down muscles and lead to kidney damage. Very rarely, statins like simvastatin can also cause immune-mediated necrotizing myopathy (IMNM). This is an autoimmune condition that causes muscle inflammation and muscle weakness. It might last even after you stop taking the statin.
Tell your care team if you have unusual muscle pain, soreness, or weakness. They can check what's going on. But get medical care right away if you have severe muscle pain, dark urine, or extreme tiredness. These can be signs of a serious muscle problem like rhabdomyolysis. Depending on your symptoms, you might need to stop taking simvastatin and get treated for the muscle problem.
Liver problems
- Risk factors: History of liver problems | Drinking large amounts of alcohol
Some people taking simvastatin had higher liver enzyme levels. This can be a sign of liver damage. Most times, these changes happened soon after starting the medication. They're usually temporary and don't cause symptoms. But in rare cases, serious liver problems, including liver failure, have happened.
Before starting simvastatin, let your prescriber know if you have any liver problems. They might also ask for you to get a blood test done to check your liver health. People who have liver problems or high liver enzyme levels shouldn't take this medication.
While taking simvastatin, your prescriber might ask for more blood tests to check your liver. Watch for signs of liver damage and get medical help right away if you notice them. These signs include yellowish skin or eyes, stomach pain or swelling, nausea, vomiting, dark urine, or dark or bloody stools. You might need to stop taking simvastatin to protect your liver.
Higher blood sugar levels
- Risk factors: High blood sugar
Some research suggests that statins like simvastatin might slightly raise blood sugar levels. This can sometimes lead to a higher A1C, which is your average blood sugar over about 3 months. Even so, healthcare professionals believe the benefits of statins are greater than this small risk.
Tell your prescriber if you have diabetes or high blood sugar so they know to follow up with you about this. You might need to check your blood sugar more often. While taking simvastatin, remember to eat healthy, balanced meals and get regular exercise.
Possible risk of harm when taken while pregnant or breastfeeding
If you become pregnant, stop taking simvastatin and tell your prescriber right away. This medication isn't recommended during pregnancy unless the benefits are greater than the risks. Statins might harm an unborn baby. Talk to your prescriber about the safest treatment options for you if you're pregnant or planning to become pregnant.
Breastfeeding is also not recommended while you're taking simvastatin. Some statins can pass into breast milk and might harm your baby. Talk to your prescriber or a lactation expert about safe ways to feed your baby.
More on Simvastatin warnings
Simvastatin dosage
The average cost for 90 tablets of 20mg of Simvastatin is $14.63 with a free GoodRx coupon. This is 80.50% off the average retail price of $75.04. 
Tablet
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 20mg | 90 tablets | $14.63 | $0.16 |
| 40mg | 90 tablets | $17.82 | $0.20 |
| 5mg | 90 tablets | $15.42 | $0.17 |
| 80mg | 90 tablets | $20.39 | $0.23 |
| 10mg | 90 tablets | $9.07 | $0.10 |
Typical dosage for Simvastatin
-
- Adults: The typical dose ranges from 20 mg to 40 mg by mouth once daily in the evening.
- Children ages 10 years and older with HeFH: The typical dose ranges from 10 mg to 40 mg by mouth once daily in the evening.
-
Simvastatin liquid suspension (FloLipid):
- People ages 10 years and older: The typical dose ranges from 5 mg to 40 mg by mouth once daily in the evening.
Your dose might be different if you have kidney problems or if you take certain medications that interact with simvastatin.
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Interactions between Simvastatin and other drugs
Simvastatin may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Simvastatin. Please note that only the generic name of each medication is listed below.
More on Simvastatin interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Amprenavir
- Atazanavir
- Boceprevir
- Clarithromycin
- Cobicistat
- Cyclosporine
- Danazol
- Darunavir
- Erythromycin
- Fosamprenavir
- Gemfibrozil
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Letermovir
- Lopinavir
- Mibefradil
- Mifepristone
- Nefazodone
- Nelfinavir
- Paritaprevir
- Posaconazole
- Ritonavir
- Saquinavir
- Telaprevir
- Telithromycin
- Tipranavir
- Voriconazole
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acenocoumarol
- Amiodarone
- Amlodipine
- Azithromycin
- Bempedoic Acid
- Bezafibrate
- Carbamazepine
- Ceritinib
- Ciprofibrate
- Ciprofloxacin
- Clofibrate
- Colchicine
- Conivaptan
- Dabigatran Etexilate
- Dalfopristin
- Daptomycin
- Darolutamide
- Delavirdine
- Diltiazem
- Dronedarone
- Duvelisib
- Eltrombopag
- Enasidenib
- Eslicarbazepine Acetate
- Fenofibrate
- Fenofibric Acid
- Fluconazole
- Fosnetupitant
- Fusidic Acid
- Glecaprevir
- Ivosidenib
- Larotrectinib
- Lefamulin
- Leflunomide
- Levamlodipine
- Lomitapide
- Lorlatinib
- Lumacaftor
- Netupitant
- Niacin
- Pazopanib
- Pibrentasvir
- Quinupristin
- Ranolazine
- Risperidone
- Simeprevir
- Tadalafil
- Teriflunomide
- Verapamil
- Warfarin
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Albiglutide
- Alitretinoin
- Bosentan
- Cilostazol
- Clopidogrel
- Digoxin
- Efavirenz
- Fosphenytoin
- Fostemsavir
- Interferon Beta
- Levothyroxine
- Oat Bran
- Oxcarbazepine
- Pectin
- Phenytoin
- Rifampin
- St John's Wort
- Ticagrelor
How much does Simvastatin cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Simvastatin contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Simvastatin will not be safe for you to take.
- Take certain azole antifungals, macrolide antibiotics, or antiviral medications
- Take nefazodone, danazol, or gemfibrozil (Lopid)
- Take cyclosporine modified (Neoral or Gengraf) or cyclosporine (Sandimmune)
- Liver problems
What are alternatives to Simvastatin?
There are a number of medications that your doctor can prescribe in place of Simvastatin. Compare a few possible alternatives below.
News about Simvastatin
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PCSK9 Inhibitors vs. Statins for High Cholesterol: 7 Ways They Compare
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Protecting Your Heart: 7 Reasons Why You Shouldn’t Suddenly Stop Your Statin
Healthcare professionals warn against suddenly stopping statins because the risk of serious heart problems can go up. Learn about the risks of stopping statins here.
Are OTC Statins Available? Not Yet, But They Could Be Soon
Statins are a medication class commonly prescribed to treat high cholesterol. Research indicates OTC statins may be available soon. Learn more.
What Medications Are Typically Prescribed After Having a Heart Attack (Myocardial Infarction)?
Your cardiologist may prescribe statins or other medications after a heart attack to aid treatment. Here’s a list of common medications for myocardial infarction.
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Medications like Tylenol and Aleve are hepatotoxic, meaning they could raise liver enzymes and damage your liver over time. See the list of medications to avoid.
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You can get the most from statin medications by following some simple tips. Learn when’s the best time to take cholesterol medication, what to eat, and more.
Simvastatin images
