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Niaspan vs. Lovaza

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Niacin ER (niacin) and Omega-3 acid ethyl esters (Lovaza) are both used to manage cholesterol and triglyceride levels, but they have different uses and side effects. Niacin ER is a form of vitamin B3 and is used to lower high cholesterol and triglycerides, as well as to reduce the risk of repeat heart attacks and slow plaque buildup in arteries. Common side effects include flushing and stomach upset. On the other hand, Omega-3 acid ethyl esters (Lovaza) is made up of two omega-3 fatty acids, EPA and DHA, and is specifically used to lower very high triglyceride levels. It is only available by prescription and can cause side effects like burping, upset stomach, and changes in taste. Unlike niacin ER, Lovaza is not known to cause flushing. Both medications are taken orally, but niacin ER is typically taken once daily at bedtime, while Lovaza can be taken once or twice daily with food. Additionally, Lovaza is not recommended for people with fish or shellfish allergies, whereas niacin ER has no such restriction.

niacin ER

 

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Omega-3 acids

(Lovaza)

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Summary for Niaspan

Prescription or over-the-counter

Niacin ER (also known as vitamin B3) is a prescription antilipemic medication for adults. It's used to lower high cholesterol and triglycerides (a common form of fat) levels, but it's not a first-choice option for this condition. Niacin ER is taken by mouth once daily, while niacin (Niacor) is typically taken three times daily. Some side effects of niacin ER include flushing and stomach upset. Please note that niacin is also available over-the-counter to treat vitamin B3 deficiency.

Indications for Niaspan

  • High cholesterol and high triglycerides
  • Lower risk of repeat heart attack in people with a history of heart attack and high cholesterol
  • Slow plaque buildup in the arteries of people with a history of coronary artery disease (CAD) and high cholesterol (as an add-on medication)
  • Severely high triglycerides in people who are at risk of pancreatitis (as an add-on medication)

Pros and Cons for Niaspan

Pros

  • Can lower “bad” (LDL) cholesterol and raise “good” (HDL) cholesterol in people who have trouble doing so with diet and exercise alone
  • Can also lower triglycerides
  • An option for people who didn’t have success or had side effects with statins
  • Available as a lower-cost generic medication

Cons

  • Doesn’t work as well as statin medications in lowering cholesterol and triglycerides
  • Can cause flushing, a bothersome side effect
  • Need to take immediate-release form multiple times a day
  • Not recommended during pregnancy or breastfeeding

Common Side Effects for Niaspan

Extended-release tablets:

  • Flushing (up to 69%)
  • Diarrhea (up to 14%)
  • Nausea (up to 11%)

Warnings for Niaspan

  • Muscle breakdown that can lead to kidney and heart damage (rhabdomyolysis)
  • Liver damage

Summary for Lovaza

Prescription only

Omega-3-acid ethyl esters (Lovaza) is made up of two different omega-3 fatty acids: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This medication is used to lower triglycerides (TG) levels in adults. It works best when you're also eating a low-cholesterol diet and engaging in regular exercise. Omega-3 acids (Lovaza) is taken by mouth once or twice per day with food. Some side effects include burping, upset stomach, and changes in your sense of taste.

Indications for Lovaza

  • Add-on to diet for the treatment of high triglycerides (TG) in adults with TG levels greater than 500 mg/dL

Pros and Cons for Lovaza

Pros

Cons

  • Approved for adults only
  • Might not be appropriate for people with fish or shellfish allergies
  • Can cause burping and changes in taste as side effects
  • Capsule might be hard to swallow for some people

Common Side Effects for Lovaza

  • Burping (4%)
  • Changes in taste (4%)
  • Upset stomach (3%)

Warnings for Lovaza

  • Fish allergy
  • Heart rhythm problems (atrial fibrillation or atrial flutter)
  • Risk of liver irritation

Prices with our coupons for Niaspan vs. Lovaza

Price Card Drug Icon
Niacin ER90 tablets / 500mg
$29.95-
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Price Card Drug Icon
Omega-3-Acid Ethyl Esters120 capsules / 1g
$33.40$71.70
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