Key takeaways
Simvastatin (Zocor) and Atorvastatin (Lipitor) are both statins used to lower "bad" cholesterol (LDL) and triglycerides, while raising "good" cholesterol (HDL). However, there are some key differences between the two. Simvastatin (Zocor) is considered a low-to-moderate intensity statin, while Atorvastatin (Lipitor) is a moderate-to-high intensity statin, meaning Atorvastatin can lower cholesterol more effectively at certain doses. Simvastatin is typically taken at night because it is short-acting, whereas Atorvastatin can be taken at any time of the day due to its long-acting nature. Both medications are available in generic forms, making them more affordable. Simvastatin has a higher risk of causing severe muscle damage (rhabdomyolysis) compared to other statins, while Atorvastatin has a potential risk of causing strokes or brain bleeds in people who recently had a stroke. Both medications should not be used during pregnancy or breastfeeding.
