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Simvastatin vs. Livalo

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Simvastatin (Zocor) and pitavastatin (Livalo) are both statins used to lower cholesterol, but they have some key differences. Simvastatin is available in a cheaper generic form, while Livalo does not have a generic alternative. Simvastatin is a first-choice medication for lowering cholesterol and reducing the risk of heart attack and stroke, whereas Livalo has not been shown to lower the risk of these events. Livalo may be better for you if you have experienced muscle pain with other statins or have a kidney condition, as it is less likely to cause muscle and kidney damage. Additionally, Livalo has fewer drug interactions, making it a good option if you take multiple medications. Both medications should not be used during pregnancy or breastfeeding, but Livalo is noted for its higher cost if not covered by insurance.

Simvastatin

 

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Pitavastatin calcium

(Livalo)

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Summary for Simvastatin

Prescription only

Simvastatin is a low-to-moderate intensity statin that helps lower cholesterol. This helps lower the risk of serious problems like heart attack or stroke. It's approved for adults and certain children 10 years and older. Simvastatin tablets are available as brand-name Zocor and a generic. The liquid suspension form only comes as brand-name FloLipid. The simvastatin dose is taken by mouth once each night. It works best when you also eat heart-healthy foods and stay active. Possible side effects are stomach pain, muscle pain, and headache.

Indications for Simvastatin

Pros and Cons for Simvastatin

Pros

  • Can lower "bad" cholesterol (LDL) by up to 49% at certain doses
  • Taken once a night
  • Has an oral solution version (FloLipid) that's an option for people who have trouble swallowing tablets
  • Approved for children as young as 10 years old with HeFH

Cons

  • Has the highest risk among the statins to cause muscle pain
  • Has some drug interactions, like with certain heart medications and grapefruit
  • Can't take if you have certain liver problems
  • Not recommended to take while pregnant or breastfeeding

Common Side Effects for Simvastatin

  • Bronchitis (7%)
  • Stomach pain (6%)
  • Irregular heartbeat (6%)
  • Inflamed stomach lining (nausea, vomiting, low appetite; 5%)
  • Eczema (dry, itchy skin; 5%)
  • Vertigo (dizzy, feeling like the room is spinning; 5%)

Warnings for Simvastatin

  • Severe muscle pain and damage
  • Liver problems
  • Higher blood sugar levels
  • Possible risk of harm when taken while pregnant or breastfeeding

Summary for Livalo

Prescription only

Pitavastatin calcium, also known by its brand name, Livalo, is a moderate-intensity statin for people with high cholesterol. It lowers "bad" cholesterol and triglycerides (fats) and raises "good" cholesterol in the body. Pitavastatin calcium (Livalo) is a tablet that's taken by mouth once per day at any time of day. It's important to follow a heart-healthy diet while taking the medication to get the most benefits from treatment. Side effects include muscle pain, back pain, and constipation. Pitavastatin calcium (Livalo) is available as a brand-name and generic medication.

Indications for Livalo

Pros and Cons for Livalo

Pros

  • Generally lowers "bad" cholesterol (LDL) by about 30% to 49%
  • Taken once per day with or without food
  • Okay for children as young as 8 years old to take for HeFH

Cons

  • Not the best choice for people who need a high-intensity statin
  • Can't crush the tablets, so might not be a good option for people who have trouble swallowing pills whole
  • Not safe to take while pregnant or breastfeeding

Common Side Effects for Livalo

  • Back pain (up to 4%)
  • Constipation (up to 4%)
  • Muscle pain (up to 3%)
  • Diarrhea (up to 3%)
  • Pain in the arm or leg (up to 2%)

Warnings for Livalo

  • Severe muscle pain and damage
  • Liver problems
  • Higher blood sugar levels
  • Possible risk of harm during pregnancy or breastfeeding

Prices with our coupons for Simvastatin vs. Livalo

Price Card Drug Icon
Simvastatin90 tablets / 20mg
$14.79$85.52
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Price Card Drug Icon
Pitavastatin30 tablets / 2mg
$47.13$356.22
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