Key takeaways
Niacin ER (niacin) and Rosuvastatin (Crestor) are both used to manage high cholesterol, but they work differently and belong to different medication classes. Niacin ER is an antilipemic and a form of vitamin B3, which helps lower bad cholesterol (LDL) and triglycerides while raising good cholesterol (HDL). Rosuvastatin, on the other hand, is a statin that blocks an enzyme in the liver to lower bad cholesterol and triglycerides. Niacin ER is taken once daily at bedtime, while Rosuvastatin can be taken any time of the day. Common side effects of Niacin ER include flushing and stomach upset, whereas Rosuvastatin may cause muscle pain, joint pain, and headache. Both medications can cause serious side effects like liver damage, but Rosuvastatin is generally considered a first-choice medication for lowering cholesterol.
