Key takeaways
Omega-3-acid ethyl esters (Lovaza) and gemfibrozil (Lopid) are both used to lower triglycerides, but they work differently and belong to different medication classes. Lovaza is an antilipemic made up of omega-3 fatty acids, while Lopid is a fibrate that helps break down fats and lowers their production in the liver. Lovaza is taken once or twice a day with food, whereas Lopid is taken twice a day, 30 minutes before meals. Lovaza can cause burping and changes in taste, while Lopid commonly causes indigestion, stomach pain, and diarrhea. Lovaza is not known to interact with statins, but Lopid can interact with them, increasing the risk of muscle damage. Additionally, Lovaza is not suitable for people with fish allergies, and Lopid is not recommended for those with liver, kidney, or gallbladder problems. Both medications are available as lower-cost generics.
