Key takeaways
Niacin ER (niacin) and Fenofibrate (fenofibrate) are both used to manage high cholesterol and triglycerides, but they belong to different medication classes and work in distinct ways. Niacin ER, also known as vitamin B3, is an antilipemic that helps lower "bad" LDL cholesterol and triglycerides while raising "good" HDL cholesterol. Common side effects include flushing and stomach upset. Fenofibrate, on the other hand, is a fibrate that primarily lowers triglycerides and also helps with LDL and HDL cholesterol levels. It is only available by prescription and comes in various brand names and generic forms. Fenofibrate can cause stuffy nose, back pain, and stomach pain. Unlike niacin ER, fenofibrate does not need to be taken at night and can be taken with or without food depending on the brand. Both medications can cause serious side effects, such as liver damage. Fenofibrate can also cause muscle damage, while this side effect is only expected with Niacin ER when taken with statins. However, fenofibrate also carries risks of blood clots.
