Key takeaways
Niacin ER (niacin) and Gemfibrozil (Lopid) are both used to manage cholesterol and triglyceride levels, but they belong to different medication classes and have distinct usage guidelines. Niacin ER is an antilipemic and a form of vitamin B3, and is typically taken once daily at bedtime. It works by blocking fat release from tissues and slowing cholesterol production in the liver. Common side effects include flushing and stomach upset. On the other hand, Gemfibrozil is a fibrate, and is taken twice daily before meals. It helps break down fats and lowers their production in the liver. Common side effects include indigestion, stomach pain, and diarrhea. While both medications can interact with statins, Gemfibrozil has a higher risk of causing muscle damage when combined with statins. Additionally, Niacin ER can cause liver damage and is not recommended for those with active liver disease, whereas Gemfibrozil is contraindicated in individuals with liver, kidney, or gallbladder problems.
