Key takeaways
Ezetimibe (Zetia) and fenofibrate (Tricor, Trilipix) are both medications used to manage cholesterol levels, but they work in different ways and have distinct uses. Ezetimibe is a cholesterol absorption inhibitor that lowers "bad" cholesterol (LDL) by reducing its absorption in the gut. It's often added to statin therapy or used as an alternative for those who can't tolerate statins. Fenofibrate, on the other hand, is a fibrate that not only lowers LDL but also significantly reduces triglycerides and raises "good" cholesterol (HDL). Unlike ezetimibe, fenofibrate is not typically combined with statins due to the increased risk of muscle damage. Ezetimibe is generally well-tolerated with few side effects, while fenofibrate can cause liver problems, muscle pain, and other serious side effects. You may need blood tests to monitor your liver and kidney function while taking fenofibrate, while this isn't typical with ezetimibe. Both medications are available in generic forms and are taken once daily. Fenofibrate is not recommended during pregnancy or breastfeeding, and the safety of ezetimibe in these conditions is also uncertain.
