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Cyclosporine Modified Coupon - Cyclosporine Modified 100mg capsule

cyclosporine modified

Generic Neoral
Used for Plaque Psoriasis, Rheumatoid Arthritis, Organ Transplant
Used for Plaque Psoriasis, Rheumatoid Arthritis, Organ Transplant

Cyclosporine modified (Neoral) is an immunosuppressant that helps prevent organ rejection after a kidney, liver, or heart transplant. It also treats severe rheumatoid arthritis and plaque psoriasis in adults. This medication comes in soft gelatin capsules and an oral solution. It's taken by mouth twice daily at a dosage that depends on your condition. Side effects can include high blood pressure, a lot of hair growth all over, and kidney problems. But it also has serious risks like infection and cancer. It's typically taken together with other medications. And although cyclosporine modified (Neoral) is interchangeable with Gengraf, it's not interchangeable with Sandimmune.

Last reviewed on February 3, 2025
basics-icon

What is Cyclosporine modified (Neoral)?

What is Cyclosporine modified (Neoral) used for?

How Cyclosporine modified (Neoral) works

Cyclosporine modified (Neoral) is a type of immunosuppressant medication. It lowers (or suppresses) the activity of your immune system. More specifically, the medication is a calcineurin inhibitor. It works by stopping a protein in the body called calcineurin from telling your immune system to become active.

  • For preventing organ rejection after a transplant: Your body recognizes the new organ as a foreign object. Your immune system fights to reject the new organ after the transplant. Cyclosporine modified (Neoral) stops your immune system from attacking the new organ, which lowers the risk for organ rejection.

  • For treating rheumatoid arthritis and plaque psoriasis: These medical conditions are caused by an overactive immune system. The immune system mistakes healthy tissue in your body as a foreign object and attacks it, leading to inflammation. Cyclosporine modified (Neoral) works to treat rheumatoid arthritis and plaque psoriasis by stopping your immune system from attacking your own body.

Are you looking for information on cyclosporine modified (Gengraf) or cyclosporine (Sandimmune) instead?

Drug Facts

Common BrandsNeoral
Drug ClassImmunosuppressant
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Cyclosporine modified (Neoral)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

For preventing rejection after kidney, liver, or heart transplant:
Side effects for transplant were reported in people taking a similar medication called cyclosporine (Sandimmune)
  • Shaking (up to 55%)
  • High blood pressure (up to 53%)
  • Excessive hair growth on face, back, and chest (up to 45%)
  • Kidney problems (up to 38%)
  • Urinary tract infection (21%)
  • Viral infections (16%)
  • Overgrowth of gums (up to 16%)
  • Nausea or vomiting (up to 10%)
For rheumatoid arthritis:
  • Higher creatinine levels (possible kidney problem; up to 48%)
  • Headache (25%)
  • High blood pressure (25%)
  • Nausea (18%)
  • Stomach pain (15%)
  • Excessive hair growth on face, back, and chest (15%)
  • Diarrhea (13%)
  • General pain (13%)
  • Shaking (13%)
  • Upper respiratory tract infection (13%)
  • Muscle cramps (12%)
  • Numbness, tingling, or burning in arms or legs (11%)
For psoriasis:
  • High blood pressure (28%)
  • Infection (25%)
  • Higher creatinine levels (possible kidney problem; 20%)
  • Headache (16%)
  • High triglyceride levels (15%)

Other Side Effects

  • Diarrhea
  • Indigestion
  • Swelling
  • Dizziness
  • Infections or flu-like symptoms
  • Chest pain
  • Mouth sores
  • Cough
  • Difficulty breathing
  • Stuffy nose
  • Flushed skin
  • Rash

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious infection: fever, difficulty breathing, muscle weakness, confusion, memory problems, loss of balance or coordination, not able to move
  • Severely high blood pressure: headache, difficulty breathing, chest pain or pressure, blurred vision, fast heartbeat, nose bleed, confusion
  • Kidney damage: urinating less, swelling in feet or legs, shortness of breath, tiredness, weakness, muscle cramps, nausea, vomiting, confusion
  • Liver damage: yellowing of the skin or eyes (jaundice), stomach pain or swelling, loss of appetite, nausea, vomiting, dark urine, tiredness, weakness, confusion
  • Brain damage: vision problems (e.g., blurred vision, double vision, loss of vision), loss of muscle control, movement problems, changes in thoughts or behavior, seizures, loss of consciousness

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal or stomach pain or tenderness

back pain

black, tarry stools

blurred vision

chest pain

chills

clay colored stools

cloudy urine

cough

dark urine

decrease in urine output or decrease in urine-concentrating ability

decreased appetite

dizziness

drowsiness

fever

headache

headache, severe and throbbing

itching

loss of appetite

muscle spasms (tetany) or twitching

nausea and vomiting

nervousness

painful or difficult urination

pounding in the ears

shakiness in the legs, arms, hands, or feet

shortness of breath

skin rash

slow or fast heartbeat

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swelling of the feet or lower legs

swollen glands

trembling or shaking of the hands or feet

unusual bleeding or bruising

unusual tiredness or weakness

yellow eyes or skin

Less common

Bleeding gums

blood in the urine

blood in the vomit

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

convulsions

difficulty swallowing

hives

pale skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

severe or continuing stomach pain

tightness in the chest

troubled breathing with exertion

Rare

Bloating

chest discomfort

constipation

darkened urine

hoarseness

indigestion

lower back or side pain

night sweats

pain or discomfort in the arms, jaw, back, or neck

pains in the stomach, side, or abdomen, possibly radiating to the back

sweating

vomiting of blood or material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal or stomach discomfort

bleeding, tender, or enlarged gums

blemishes on the skin

increased hair growth, especially on the face

pain or tenderness around the eyes and cheekbones

pimples

stuffy or runny nose

Less common

Brittle fingernails

burning feeling in the chest or stomach

burning, dry, or itching eyes

continuing ringing or buzzing or other unexplained noise in the ears

cramps

discharge or excessive tearing

feeling of warmth

hearing loss

redness of the face, neck, arms, and occasionally, upper chest

redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

swelling of the breasts or breast soreness in both females and males

weight loss

Rare

Blurred or loss of vision

discouragement

disturbed color perception

double vision

fear

feeling sad or empty

halos around lights

irritability

joint pain

loss of interest or pleasure

night blindness

overbright appearance of lights

tiredness

trouble concentrating

trouble sleeping

tunnel vision

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

weakness

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Cyclosporine modified (Neoral)

thumbs-up

Pros

Comes as an easy-to-swallow soft gelatin capsule and liquid solution

Can help treat severe rheumatoid arthritis and plaque psoriasis when other medications haven't worked well

thumbs-down

Cons

Might need regular blood draws to check medication levels in your body

Has a risk of serious infections and certain types of cancer

Can't easily switch back and forth with cyclosporine (Sandimmune)

pharmacist-tips

Pharmacist tips for Cyclosporine modified (Neoral)

pharmacist
  • Take cyclosporine modified (Neoral) twice during the day at the same times each day. Also be consistent with taking the medication with food or without food. This helps make sure the cyclosporine levels in your body stay as stable as possible.

    • Your cyclosporine modified (Neoral) dose depends on the level of medication in your blood. You'll need regular blood draws done to check your cyclosporine levels. This helps your prescriber see whether your levels are within a safe range and whether you need any dose adjustments to get you to that range. Ask your prescriber how often you need to do lab work.

      • Don't make any changes to your dose or switch to cyclosporine (Sandimmune) without talking to your prescriber first. Cyclosporine modified (Neoral) and cyclosporine (Sandimmune) aren't equal to each other so it's not easy to switch between them. Your prescriber has to check your cyclosporine levels with any changes to treatment to make sure it's done safely. Treatment changes without guidance can lead to serious risks (e.g., transplant organ rejection, kidney damage).

        • Don't eat grapefruit or drink grapefruit juice while you're taking cyclosporine modified (Neoral). Grapefruit can make the cyclosporine levels in your body go up. This can lead to harmful effects, such as damage to the kidneys or liver.

          • Cyclosporine modified (Neoral) can cause kidney damage. Get medical care right away if you notice that you aren't urinating as much or if you have symptoms such as swelling in your feet or legs, trouble breathing, tiredness, or confusion.

            • Ask your pharmacist or prescriber about which vaccines you can get while you're taking cyclosporine modified (Neoral). Before you get any vaccines, let the healthcare professional know that you're taking this medication. Some vaccines might not work as well. And avoid live vaccines, like Varivax (chickenpox vaccine) or the nasal spray flu vaccine. Your risk of getting sick from the live vaccine itself is higher because this medication lowers your ability to build immunity.

              Other tips for the cyclosporine modified (Neoral) solution:

              • Only use the dosing syringe included in the original packaging to measure out the dose for the solution. Avoid using kitchen spoons because they won't give you an accurate dose. Ask your pharmacist if you're not sure whether you're measuring the dose correctly with the right kind of dosing syringe.

                • From the dosing syringe, place the measured amount of medication into a glass cup (not plastic) with some room-temperature orange or apple juice. Mix and then drink it right away. Add some more juice, mix, and drink what's left to make sure you get a full dose of your medication. Mixing the medication with juice helps it taste better and make it easier to swallow. Don't mix it with milk or grapefruit juice.

                  • After you take cyclosporine modified (Neoral), use a clean towel to dry the outside of the dosing syringe and then put the protective cover back onto the bottle. Don't wash the syringe with water or any other cleaning agents. Be sure the dosing syringe is completely dry before you use it again.

                    • Once you've opened the bottle of cyclosporine modified (Neoral) solution, use the medication in the bottle within 2 months.

                      • Place the cyclosporine modified (Neoral) solution somewhere safe at room temperature (between 68ºF and 77ºF). The solution can turn into a gel with small chunks in it if it gets below 68°F. This won't damage the medication; let it reach the appropriate temperature range and the gel should turn back into a liquid.

                        faqs

                        Frequently asked questions about Cyclosporine modified (Neoral)

                        Can cyclosporine modified (Neoral) capsules be opened?
                        No, you can't open the cyclosporine modified (Neoral) soft gelatin capsules. Don't cut or chew them because it might lead to harmful effects. Swallow the cyclosporine modified (Neoral) capsules whole. Talk with your prescriber about possibly switching to the oral solution form of the medication if you're having trouble swallowing the capsules whole.
                        Is cyclosporine modified (Neoral) taken with food?
                        You can take cyclosporine modified (Neoral) either with food or without food. Keep in mind that food can affect how much of the medication your body absorbs. So what's important is that you're consistent with how you take cyclosporine modified (Neoral). This means that you should decide to either always take it with a meal or always take it on an empty stomach. This will help keep your cyclosporine levels as steady as possible in the body. A possible reason to decide to always take it with food is if you notice that you feel nauseous after you take the medication. Food might help lessen this side effect.
                        What foods should you avoid when you're taking cyclosporine modified (Neoral)?
                        Don't eat grapefruit or drink grapefruit juice while you're taking cyclosporine modified (Neoral). Also avoid mixing the solution form of the medication with grapefruit juice. Grapefruit can raise the cyclosporine levels in your body. This can lead to harmful effects, such as a higher risk of infections or kidney problems. You should also avoid mixing the solution form of cyclosporine modified (Neoral) with milk. It won't taste good and there aren't any studies about whether the medication works well when mixed with milk. Keep in mind that other fruits, like pomegranate and bitter oranges (Seville oranges), might be harmful to eat with transplant medications like cyclosporine modified (Neoral). So, it's best to check with your care team for a full list of foods to avoid.
                        What's the difference between cyclosporine modified (Neoral) and cyclosporine (Sandimmune)?
                        Cyclosporine modified (Neoral) and cyclosporine (Sandimmune) are both transplant medications that help prevent rejection. They both contain cyclosporine, but they're absorbed into the body differently. Cyclosporine modified (Neoral) is made to have better and more stable absorption into the body than the same dose of cyclosporine (Sandimmune). So, they aren't interchangeable (meaning you can't just switch back and forth between them without guidance from your prescriber). Ask your transplant specialist about comparing between the two medications and discuss which option is best for you.
                        Are Neoral and Gengraf interchangeable?
                        The manufacturer of Gengraf states that Gengraf are interchangeable. This means that you can switch between these medications. Neoral and Gengraf have the same active ingredient: cyclosporine modified. And they have similar properties as each other. Still, it's always recommended to speak with your prescriber before you make any changes to your medications. Your prescriber can make sure any treatment changes are done safely.
                        Is it safe to take cyclosporine modified (Neoral) while pregnant?
                        Discuss the risks and benefits of taking cyclosporine modified (Neoral) with your prescriber if you're pregnant or planning on becoming pregnant. There aren't enough studies to know for sure about how safe the medication is to take during pregnancy. In some studies, people who've had an organ transplant and were exposed to cyclosporine while pregnant had harmful complications, such as having high blood pressure, giving birth prematurely, or giving birth to a low birth weight baby. Cyclosporine modified (Neoral) also contains alcohol, which can cause serious harm to your unborn baby. If you're pregnant and you've taken cyclosporine modified (Neoral), there's a pregnancy exposure registry that you can enroll in. This registry helps researchers learn more about the risks of taking cyclosporine modified (Neoral) during pregnancy.
                        Is it safe to take cyclosporine modified (Neoral) while breastfeeding?
                        There aren't enough studies to know for sure how safe it is to take cyclosporine modified (Neoral) while breastfeeding. But the medication can pass into human breast milk. Cyclosporine modified (Neoral) also contains a alcohol, which can pass into breast milk and cause serious harm to your breastfed baby. Speak with your prescriber or lactating consultation about the risks and benefits of taking cyclosporine modified (Neoral) while breastfeeding. They can offer other ways to feed your baby that might be safer, such as using baby formula.
                        Is it safe for children to take cyclosporine modified (Neoral)?
                        Speak with your child's prescriber if you have questions about whether cyclosporine modified (Neoral) is a good option for your child. There aren't enough studies done that look into how safe the medication is for preventing organ rejection after transplantation, treating rheumatoid arthritis, or treating psoriasis in children. But in a few small studies, children as young as 1 years old who've had an organ transplant have taken cyclosporine modified (Neoral) under the supervision of an experienced transplant specialist without any unusual side effects.
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                        What are the risks and warnings for Cyclosporine modified (Neoral)?

                        Cyclosporine modified (Neoral) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                        risk-warning

                        Prescribing physician must be experienced and treatment must be monitored

                        Cyclosporine modified (Neoral) should only be prescribed by a trained healthcare professional (HCP) who has experience with managing your condition (e.g., organ transplant, autoimmune condition). For your safety, your HCP will take detailed notes and closely monitor you at a hospital or clinic with all of the necessary medical resources to manage your treatment with cyclosporine modified (Neoral).

                        risk-warning

                        Not equal to cyclosporine (Sandimmune)

                        • Risk factors: Switching between cyclosporine modified (Neoral) and cyclosporine (Sandimmune)

                          Cyclosporine modified (Neoral) is NOT equal to cyclosporine (Sandimmune), which is approved for preventing organ rejection after transplantation only. You can’t replace or interchange one with the other without first getting guidance from your prescriber. This is because you absorb more cyclosporine modified (Neoral) into the body than cyclosporine (Sandimmune). Switching between one form of cyclosporine to the other at the same dose changes the amount of medication in the body. This can lead to harmful consequences.

                          If your prescriber decides to switch between cyclosporine modified (Neoral) and cyclosporine (Sandimmune), they'll need to closely monitor the cyclosporine levels in your blood. This makes sure your cyclosporine levels are within a safe range. Levels that are too low can lead to organ rejection. And levels that are too high can lead to serious harm such as kidney or liver damage. Your transplant specialist will adjust your dose based on your cyclosporine levels.

                          risk-warning

                          Risk of serious infections

                          • Risk factors: History of frequent infections | Had an organ transplant | Taking other medications that lower your immune system

                            Cyclosporine modified (Neoral) works by lowering or suppressing the activity of your immune system. It puts you at risk of infections that can become serious or even life-threatening. These can also include opportunistic infections (infections that usually only cause problems when the immune system is weak), like polyoma virus infections.

                            Your risk for serious bacterial, viral, or fungal infections is higher if you’re taking other medications that also weaken your immune system at the same time as cyclosporine modified (Neoral). This is especially common for people who've had an organ transplant. Let your prescriber know if you have a history of having frequent infections or if you're taking other immunosuppressants.

                            Contact an HCP if you have any signs of an infection, like fever, trouble breathing, cough, or chills. Also get medical help right away if you have muscle weakness, confusion, memory problems, loss of coordination, or paralysis. These can be signs of a serious infection that needs immediate medical attention.

                            risk-warning

                            Risk of cancer

                            • Risk factors: History of cancer | Undergoing phototherapy | Taking methotrexate | Using coal tar | Radiation therapy | Exposure to a lot of sunlight or ultraviolet (UV) light | Taking cyclosporine modified (Neoral) long term | Taking other medications that can weaken the immune system

                              People who take cyclosporine modified (Neoral) are at higher risk for tumors and cancer, including lymphomas and skin cancer, among others. This is because the medication lowers (or suppresses) the activity of your immune system. Speak with your prescriber if you're worried about the risk for cancer during treatment.

                              Before you start cyclosporine modified (Neoral), let your care team know if you have a history of cancer. Also tell them if you're taking other immunosuppressants or getting treated with therapies that raise the risk for skin cancer (e.g., phototherapy, methotrexate). They can check your risk for cancer.

                              Lower your risk for skin cancer by avoiding excessive exposure to sunlight, using sunscreen, and wearing protective clothing when you’re outside. Contact your care team if you notice any unusual skin growths or changes to your skin while you're taking cyclosporine modified (Neoral). They can examine your skin to see what's going on.

                              risk-warning

                              High blood pressure

                              • Risk factors: History of high blood pressure | Taking medications that raise blood pressure | High doses of cyclosporine modified (Neoral) | Taking cyclosporine modified (Neoral) for a long period of time

                                Your blood pressure can go up while you're taking cyclosporine modified (Neoral), even at recommended doses. High blood pressure is a common side effect, so your prescriber will check your blood pressure every so often. This side effect is typically mild or moderate.

                                The risk for high blood pressure might be greater with higher doses and long-term treatment. Your prescriber might lower your dose of cyclosporine modified (Neoral) if you have a history of high blood pressure or if you develop high blood pressure during treatment. Some people might also need to take certain blood pressure medications to manage this side effect.

                                risk-warning

                                Kidney damage

                                • Risk factors: History of kidney problems | Older age | Taking medications that cause kidney damage | High dose of cyclosporine modified (Neoral) | Taking cyclosporine modified (Neoral) long term

                                  Cyclosporine modified (Neoral) can cause kidney damage, even at usual doses. The risk is greater with higher doses and long-term treatment. You're also at higher risk if you have a history of kidney problems or if you're taking other medications that can harm the kidneys.

                                  You'll need routine blood tests done so your prescriber can keep track of your kidney function while you’re taking cyclosporine modified (Neoral). Your prescriber might lower your dose to help manage this risk.

                                  Let your care team know if you have symptoms like low urine production, swelling in your feet or legs, trouble breathing, tiredness, weakness, muscle cramps, nausea, vomiting, or confusion. For people who've have a kidney transplant, these signs and symptoms of kidney damage can be similar to those of organ rejection. It's possible to have kidney damage and organ rejection at the same time, which can be serious.

                                  risk-warning

                                  Liver damage

                                  • Risk factors: History of liver problems | Taking medications that cause liver damage | High dose of cyclosporine modified (Neoral) | Taking cyclosporine modified (Neoral) for a long period of time

                                    Cyclosporine modified (Neoral) can cause liver damage, which can sometimes include liver failure and be life-threatening. The risk for liver damage while you're taking this medication is greater if your dose is high or if you're taking it for a long time. Some people who've had an organ transplant have had liver damage during the first month of treatment. Your prescriber will check your liver function while you're taking cyclosporine modified (Neoral).

                                    Tell your care team right away if develop symptoms of liver damage. Watch out for yellowing of your skin or eyes (jaundice), stomach pain or swelling, loss of appetite, dark urine, nausea, vomiting, tiredness, weakness, or confusion. Your prescriber might lower your dose to help manage liver problems.

                                    risk-warning

                                    Brain damage

                                    • Risk factors: Taking high doses of steroids | High blood pressure | Low magnesium levels | Low cholesterol levels | High blood levels of cyclosporine | Organ transplant, especially liver transplant | Graft-versus-host disease

                                      Some people who've taken a medication containing cyclosporine like cyclosporine modified (Neoral) have had brain damage. It can especially happen when people take this medication with high doses of steroids, such as methylprednisolone (Medrol). Your risk of brain damage might also be higher if you've had a liver transplant than if you've had a kidney transplant. The brain damage might improve with lower doses of cyclosporine modified (Neoral). In most cases, it's reversible when you stop taking the medication.

                                      Get medical help right away if you have any symptoms of brain damage so you can get checked out. Symptoms include loss of muscle control, movement problems, changes in thoughts or behaviors, seizures, or loss of consciousness. It can also include changes in vision like blurred vision, double vision, blind spots, or a loss of vision.

                                      risk-warning

                                      Low platelet and red blood cell counts

                                      • Risk factors: History of low platelet levels | History of low red blood cell count (anemia)

                                        It's not common, but some people who've taken cyclosporine modified (Neoral) have had low platelet and red blood cell counts. In people who've had an organ transplant, this might lead to failure of their transplant.

                                        It isn't known what causes low platelet and red blood cell counts in these situations. But in some people, this problem got better after lowering the dose of cyclosporine modified (Neoral) or stopping the medication (along with other treatment). Tell your care team before you start this medication if you have a history of low platelet levels or anemia.

                                        risk-warning

                                        High potassium and uric acid levels

                                        • Risk factors: History of high potassium | Taking other medications that raise potassium

                                          Some people who took cyclosporine modified (Neoral) developed high potassium levels. Tell your healthcare team if you have a history of high potassium or if you take other medications that can raise potassium levels. High potassium levels can lead to tiredness, muscle weakness, tingling or numbness, and more severely, heart problems (e.g., fast heartbeat, chest pain). Call your prescriber if you have symptoms of high potassium levels.

                                          Some people who took cyclosporine modified (Neoral) also had high uric acid levels. Too much uric acid can raise the risk for gout.

                                          risk-warning

                                          Harmful effects from alcohol

                                          • Risk factors: Drinking alcohol | Pregnancy | Breastfeeding | History of liver problems| History of seizures | History of alcohol use disorder | Children

                                            Cyclosporine modified (Neoral) has some alcohol in it. Certain people should avoid taking this medication because of possible safety concerns with alcohol. Let your prescriber know if you're pregnant or breastfeeding. Also tell them if you have liver problems or seizures. Make sure they also know if you regularly drink alcohol or if you have a history of drinking a lot of alcohol. Since the alcohol in the medication can lead to serious harm in these people, your prescriber should check for your risk before you start treatment.

                                            dosage

                                            Cyclosporine modified (Neoral) dosage forms

                                            The average cost for 30 capsules of 100mg of Cyclosporine modified (Neoral) is $633.21 with a free GoodRx coupon. This is -50.37% off the average retail price of $421.11.
                                            bottle of oral solution
                                            Bottle of oral solution
                                            DosageQuantityPrice as low asPrice per unit
                                            50ml of 100mg/ml1 bottle$637.18$637.18
                                            capsule
                                            Capsule
                                            DosageQuantityPrice as low asPrice per unit
                                            25mg180 capsules$516.62$2.87
                                            100mg60 capsules$633.21$10.55

                                            Typical dosing for Cyclosporine modified (Neoral)

                                            Generic cyclosporine modified and brand name Neoral is available as 25 mg and 100 mg soft gelatin capsules; generic cyclosporine modified also comes as 50 mg capsules. The oral solution form of the medication contains 100 mg of cyclosporine modified in each milliliter (mL).

                                            Prevention of organ rejection after new kidney, liver, or heart transplant
                                            Your dose will depend on the type of organ transplant, your risk of rejection, and the cyclosporine levels in your blood. It also depends on any serious side effects you have and the other transplant medications you're taking.

                                            • Kidney transplant: The typical starting dose can range from 6 mg/kg to 12 mg/kg of body weight by mouth, split into two equal doses each day.

                                            • Liver transplant: The typical starting dose can range from 4 mg/kg to 12 mg/kg by mouth, split into two equal doses each day.

                                            • Heart transplant: The typical starting dose can range from 4 mg/kg to 10 mg/kg by mouth, split into two equal doses each day.

                                            Treatment of rheumatoid arthritis or plaque psoriasis

                                            • The typical starting dose is 2.5 mg/kg of body weight by mouth per day, split into two equal doses throughout the day. The maximum recommended dose is 4 mg/kg, split into two equal doses each day.

                                            interactions

                                            Interactions between Cyclosporine modified (Neoral) and other drugs

                                            Cyclosporine modified (Neoral) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Cyclosporine modified (Neoral). Please note that only the generic name of each medication is listed below.

                                            Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                            Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                            Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                            drug-cost

                                            How much does Cyclosporine modified (Neoral) cost?

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                                            contraindications-icon

                                            Cyclosporine modified (Neoral) contraindications

                                            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Cyclosporine modified (Neoral) will not be safe for you to take.

                                            For all people:

                                            • Allergy to any medication containing cyclosporine

                                            For people with rheumatoid arthritis:

                                            • Kidney problems

                                            • Uncontrolled blood pressure

                                            • Cancer

                                            For people with plaque psoriasis:

                                            alternatives

                                            What are alternatives to Cyclosporine modified (Neoral)?

                                            There are a number of medications that your doctor can prescribe in place of Cyclosporine modified (Neoral). Compare a few possible alternatives below.
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                                            latest news

                                            What is the latest news about Cyclosporine modified (Neoral)?

                                            images

                                            Cyclosporine modified (Neoral) images

                                            Brown Logo 100 Mg - Cyclosporine (modified) 100mg Capsule
                                            This medicine is Brown Capsule Imprinted With "Logo 100 Mg".Brown Logo 100 Mg - Cyclosporine (modified) 100mg Capsule
                                            Yellow E0933 - Cyclosporine (modified) 100mg Capsule
                                            This medicine is Yellow Capsule Imprinted With "E0933".Yellow E0933 - Cyclosporine (modified) 100mg Capsule
                                            Yellow E0933 - Cyclosporine (modified) 100mg Capsule
                                            This medicine is Yellow Capsule Imprinted With "E0933".Yellow E0933 - Cyclosporine (modified) 100mg Capsule
                                            Gray C100 - Cyclosporine (modified) 100mg Capsule
                                            This medicine is Gray Capsule Imprinted With "C100".Gray C100 - Cyclosporine (modified) 100mg Capsule

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                                            References

                                            Best studies we found
                                            View All References (10)

                                            Centers for Disease Control and Prevention. (n.d.). PROTECT your child: Use the right tool to give the right dose.

                                            Leukemia & Lymphoma Society. (n.d.). Lymphoma.

                                            MedlinePlus. (2023). Transplant rejection.

                                            MedlinePlus. (2023). Uric acid - blood.

                                            National Kidney Foundation. (2024). Diet after kidney transplant.

                                            National Psoriasis Foundation. (n.d.). Phototherapy for psoriasis.

                                            Novartis Pharmaceuticals Corporation. (2024). Neoral- cyclosporine capsule, liquid filled; Neoral- cyclosporine solution [package insert]. DailyMed.

                                            Riccardi, N., et al. (2019). Definition of opportunistic infections in immunocompromised children on the basis of etiologies and clinical features: A summary for practical purposes. Current Pediatric Reviews.

                                            Smith Marsh, D. E. (2023). Bioequivalence and interchangeability of generic drugs. Merck Manual Consumer Version.

                                            van Mourik, I. D. M., et al. (1999). Comparison of pharmacokinetics of Neoral and Sandimmune in stable pediatric liver transplant recipients. Liver Transplantation and Surgery.

                                            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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