ACE inhibitor / thiazide diuretic combinations are used to treat high blood pressure, which can reduce the risk of heart attack and stroke. These medications work by combining an ACE inhibitor, which relaxes blood vessels, with a thiazide diuretic, which helps your body get rid of extra salt and water. This combination helps to lower blood pressure more effectively than either medication alone. These medications are available in oral form. Examples include lisinopril / hydrochlorothiazide (Zestoretic), benazepril / hydrochlorothiazide (Lotensin HCT), and enalapril / hydrochlorothiazide (Vaseretic). You can take these medications as prescribed to help manage your condition.