Key takeaways
Amlodipine (Norvasc) and Zestoretic (lisinopril/hydrochlorothiazide) are both used to treat high blood pressure, but they work in different ways and belong to different medication classes. Amlodipine is a calcium channel blocker that relaxes blood vessels to lower blood pressure and help with chest pain. It is available in both tablet and liquid forms, making it a good option for people who have trouble swallowing pills. On the other hand, Zestoretic is a combination of an ACE inhibitor (lisinopril) and a diuretic (hydrochlorothiazide). Lisinopril relaxes blood vessels by blocking a protein, while hydrochlorothiazide helps remove extra water and electrolytes from your body. Amlodipine is generally well-tolerated but can cause swelling and tiredness, while Zestoretic may cause dizziness, headache, and a dry cough. Additionally, Zestoretic is not safe for use during pregnancy or breastfeeding, whereas the safety of amlodipine during pregnancy is not well-established. Both medications are taken once daily and are available by prescription only.
