Compare Norvasc vs. Catapres-TTS

Amlodipine (Norvasc) and clonidine (Catapres-TTS, Nexiclon XR) are both used to treat high blood pressure, but they work in different ways and have different forms and side effects. Amlodipine is a calcium channel blocker that relaxes blood vessels and is typically taken once daily in tablet or liquid form. Clonidine, an alpha agonist, works by lowering stress hormones in the brain and is available as a tablet or a patch. Amlodipine is often a first-choice medication for high blood pressure and coronary artery disease, while clonidine is usually not a first-choice due to the risk of "rebound hypertension" if stopped suddenly. Clonidine can cause more side effects like dry mouth, drowsiness, and dizziness, and it is not recommended for older adults because it increases the risk of falls. Amlodipine can cause swelling and tiredness but is generally well-tolerated. Both medications are available in lower-cost generic forms.