Compare Losartan vs. Catapres-TTS

Losartan (Cozaar) and clonidine (Catapres, Nexiclon XR) are both medications used to treat high blood pressure, but they work in different ways and have distinct characteristics. Losartan is an angiotensin II receptor blocker (ARB) that helps relax blood vessels and reduce water and salt retention, making it a first-choice medication for high blood pressure, especially in people with diabetes or kidney problems. It is taken once daily and is available as a lower-cost generic. Common side effects include dizziness and upper respiratory infections. On the other hand, Clonidine is an alpha agonist that works in the brain to lower stress hormones, slowing down your heart rate and relaxing blood vessels. It comes in three forms: oral tablets (both immediate and extended-release) and a topical patch. Clonidine is not usually a first-choice medication because it can cause "rebound hypertension" if stopped suddenly and is not recommended for older adults due to the risk of falls. Common side effects include dry mouth, drowsiness, and dizziness. While Losartan is generally safer for long-term use, clonidine requires careful management to avoid withdrawal symptoms.