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Compare Propranolol vs. Baclofen

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Propranolol
Baclofen
Propranolol
Baclofen

Summary of Propranolol vs. Baclofen

Summary for Beta blocker
Prescription only

Propranolol is a non-selective beta blocker. It helps with a range of medical conditions, including high blood pressure, tremors, and migraine prevention. Sometimes, providers prescribe propranolol off-label to ease performance anxiety. You take this medication by mouth, typically 1 to 4 times daily, depending on if you're taking the immediate-release (IR) or extended-release (ER) medication. Keep in mind the IR and ER versions don't treat the same medical conditions. Some of the more common side effects of propranolol include dizziness, tiredness, or weakness.

Summary for Muscle relaxant
Prescription only

Baclofen is a muscle relaxer. It's used to treat muscle spasms from multiple sclerosis or spinal cord injuries in adults and children ages 12 years and older. This medication is taken by mouth, typically 3 times a day. Baclofen comes as tablets, as well as oral solutions (including brand names Ozobax DS and Fleqsuvy) and dissolvable granules (brand name Lyvispah) for people who've trouble swallowing tablets. Side effects of baclofen include sleepiness, dizziness, and nausea. If you stop this medication too suddenly, you might experience withdrawal symptoms.

Indications of Propranolol vs. Baclofen

Indications for
•High blood pressure
•Chronic chest pain
•Migraine
•Hypertrophic subaortic stenosis
•Atrial fibrillation (A.Fib)
•Heart protection after a heart attack
•Tremors
•Pheochromocytoma (a rare tumor of the adrenal gland)
Indications for
•Muscle spasms from multiple sclerosis or spinal cord injuries in people ages 12 years and older

Pros and Cons of Propranolol vs. Baclofen

Pros and Const for Beta blocker
Pros
•Taken by mouth
•Long-acting version only needs to be taken once a day
•Oral solution might be a good option for people who can't swallow pills
•Available as lower-cost generics
Cons
•Not safe for people with asthma or certain serious heart conditions
•Can hide many recognizable symptoms of low blood sugar, such as fast heart beat or tremors, which might prevent timely treatment
•Missing doses or suddenly stopping propranolol can raise your risk of heart attacks
Pros and Const for Muscle relaxant
Pros
•Starts to work quickly
•Can take with or without food
•Tablets and some liquid formulations are available as lower-cost generics
•Can crush or cut tablets
Cons
•Sleepiness is a common side effect
•Oral granules are available as a brand-name only
•Can cause withdrawal symptoms if stopped too quickly
•Might not be safe while pregnant

Common Side Effects of Propranolol vs. Baclofen

Common Side Effects for
•Dizziness
•Tiredness
•Feeling weak
Common Side Effects for
•Sleepiness (up to 63%)
•Dizziness (up to 15%)
•Weakness (up to 15%)
•Nausea (up to 12%)
•Confusion (up to 11%)

Warnings of Propranolol vs. Baclofen

Common Side Effects for
•Worsening of chest pain or heart attack
•Higher risk or worsening of heart failure
•Hidden symptoms of low blood sugar
•Hidden symptoms of overactive thyroid
•Trouble breathing (bronchospastic disease)
•Serious skin reactions
•Greater risk during surgery
Common Side Effects for
•Withdrawal symptoms
•Extreme sleepiness or dizziness
•Worsening of other health conditions
•Don't take during pregnancy

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