Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Topiramate (Topamax, Qudexy XR, Trokendi XR, Eprontia) and propranolol (Inderal LA, Inderal XL, Innopran XL) are both prescription medications. Both medications may be used to prevent migraines but they also have several different uses. Topiramate is an antiepileptic used to control seizures, while propranolol used for high blood pressure and chronic chest pain, among other conditions. Topiramate is available in various forms, including tablets, capsules, and a liquid solution, and can be taken once or twice daily. Propranolol comes in immediate-release and extended-release forms, with dosing ranging from once to four times daily depending on the condition being treated. Topiramate can cause side effects like difficulty thinking clearly, kidney stones, and serious eye problems, whereas propranolol can cause higher risk or worsening of heart failure, serious skin reactions, and may hide symptoms of low blood sugar or overactive thyroid. Neither medication should be stopped suddenly, as it can raise your risk of a heart attack or stroke with propranolol and risk of seizures with topiramate. Additionally, both medications have generic versions available, making them more affordable.
Topiramate
Propranolol
Topiramate
Propranolol
Summary of Topamax vs. Propranolol
Summary for Antiepileptic
Prescription only
Topiramate is a prescription medication that can be used alone or in combination with other medications to treat certain types of seizures. It can also be used to prevent migraines. It comes in immediate-release and extended-release tablets and capsules, as well as a liquid. Topiramate is typically taken by mouth once or twice daily, depending on what formulation you're using. Some forms of topiramate are available as lower-cost generic medications.
•Oral solution might be a good option for people who can't swallow pills
•Available as lower-cost generics
Cons
•Not safe for people with asthma or certain serious heart conditions
•Can hide many recognizable symptoms of low blood sugar, such as fast heart beat or tremors, which might prevent timely treatment
•Missing doses or suddenly stopping propranolol can raise your risk of heart attacks
Common Side Effects of Topamax vs. Propranolol
Common Side Effects for
Please note: These are common side effects reported by children and adults who took immediate-release topiramate. Frequency of side effects can differ based on your age, as well as the dose and formulation of topiramate you're taking.