Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Topiramate (Topamax, Qudexy XR, Trokendi XR, Eprontia) and phenytoin (Dilantin) are both antiepileptic medications used to treat seizures, but they have some key differences. Topiramate can be used alone or with other medications to treat various types of seizures and to prevent migraines, while phenytoin is only used for treating and preventing seizures. Topiramate is available in multiple forms, including tablets, capsules, and a liquid solution, and can be taken once or twice daily. In contrast, phenytoin is available as capsules, chewable tablets, and liquid, and typically requires multiple doses per day. Both medications can cause serious side effects, with topiramate increasing the risk for causing kidney stones and vision problems and phenytoin can lead to heart problems and liver damage. Additionally, both medications can affect birth control effectiveness and pose risks during pregnancy, including birth defects. Your healthcare professional may order periodic tests to measure the blood levels of these medications and monitor potential side effects.
Topiramate
Phenytoin (Dilantin)
Topiramate
Phenytoin (Dilantin)
Summary of Topamax vs. Dilantin
Summary for Antiepileptic
Prescription only
Topiramate is a prescription medication that can be used alone or in combination with other medications to treat certain types of seizures. It can also be used to prevent migraines. It comes in immediate-release and extended-release tablets and capsules, as well as a liquid. Topiramate is typically taken by mouth once or twice daily, depending on what formulation you're using. Some forms of topiramate are available as lower-cost generic medications.
Summary for Antiepileptic
Prescription only
Phenytoin (Dilantin) is an antiepileptic medication used to treat and prevent seizures in adults and children. It comes in a capsule, chewable tablet, and liquid suspension that you take by mouth. The dose depends on your age, weight, and how well your seizures are controlled. Common side effects include trouble with coordination, unpredictable eye movements, and sleepiness. You’ll need regular blood tests to avoid toxicity, which is when the amount of medication in your body is too high and could be dangerous.
Please note: These are common side effects reported by children and adults who took immediate-release topiramate. Frequency of side effects can differ based on your age, as well as the dose and formulation of topiramate you're taking.