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Compare Topamax vs. Baclofen

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Topiramate
Baclofen
Topiramate
Baclofen

Summary of Topamax vs. Baclofen

Summary for Antiepileptic
Prescription only

Topiramate is a prescription medication that can be used alone or in combination with other medications to treat certain types of seizures. It can also be used to prevent migraines. It comes in immediate-release and extended-release tablets and capsules, as well as a liquid. Topiramate is typically taken by mouth once or twice daily, depending on what formulation you're using. Some forms of topiramate are available as lower-cost generic medications.

Summary for Muscle relaxant
Prescription only

Baclofen is a muscle relaxer. It's used to treat muscle spasms from multiple sclerosis or spinal cord injuries in adults and children ages 12 years and older. This medication is taken by mouth, typically 3 times a day. Baclofen comes as tablets, as well as oral solutions (including brand names Ozobax DS and Fleqsuvy) and dissolvable granules (brand name Lyvispah) for people who've trouble swallowing tablets. Side effects of baclofen include sleepiness, dizziness, and nausea. If you stop this medication too suddenly, you might experience withdrawal symptoms.

Indications of Topamax vs. Baclofen

Indications for
•Seizures (partial seizures, tonic-clonic seizures, Lennox-Gastaut syndrome)
•Migraine prevention
Indications for
•Muscle spasms from multiple sclerosis or spinal cord injuries in people ages 12 years and older

Pros and Cons of Topamax vs. Baclofen

Pros and Const for Antiepileptic
Pros
•Can be used on its own or with other medications to control seizures
•Available in short-acting and long-acting forms, so options to take once or twice daily
•Available as a solution (Eprontia), so it's convenient for people who have trouble swallowing
•Can be used to treat different types of seizures
•Can be used to treat seizures in both adults and children
Cons
•Can prevent migraines from happening, but it won't help if you have a migraine attack
•Can cause kidney stones
•Can cause serious eye problems
•Interacts with many medications, such as warfarin (Coumadin), phenytoin (Dilantin), and divalproex (Depakote)
•Children taking this medication for long periods of time will need to have their doses adjusted often due to changes in body weight as they grow
Pros and Const for Muscle relaxant
Pros
•Starts to work quickly
•Can take with or without food
•Tablets and some liquid formulations are available as lower-cost generics
•Can crush or cut tablets
Cons
•Sleepiness is a common side effect
•Oral granules are available as a brand-name only
•Can cause withdrawal symptoms if stopped too quickly
•Might not be safe while pregnant

Common Side Effects of Topamax vs. Baclofen

Common Side Effects for

Please note: These are common side effects reported by children and adults who took immediate-release topiramate. Frequency of side effects can differ based on your age, as well as the dose and formulation of topiramate you're taking.

•Feeling "pins and needles"
•Drowsiness
•Weight loss
•Nervousness
•Fatigue
•Dizziness
•Lack of appetite
•Trouble sleeping
•Upper respiratory tract infection (e.g., cough, stuffy nose, sore throat)
•Fever
•Change in taste
•Trouble moving or keeping balance
Common Side Effects for
•Sleepiness (up to 63%)
•Dizziness (up to 15%)
•Weakness (up to 15%)
•Nausea (up to 12%)
•Confusion (up to 11%)

Warnings of Topamax vs. Baclofen

Common Side Effects for
•Vision problems
•High body temperature and trouble sweating
•Higher level of acid in blood
•Suicidal thoughts or behavior
•Problems with mood and thinking clearly
•Higher ammonia level in blood
•Serious birth defects
•Skin reactions
•Withdrawal seizures
•Interaction with other medications
Common Side Effects for
•Withdrawal symptoms
•Extreme sleepiness or dizziness
•Worsening of other health conditions
•Don't take during pregnancy

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