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baclofen
Used for Multiple Sclerosis, Spasticity
Used for Multiple Sclerosis, Spasticity
Baclofen is a muscle relaxer. It's used to treat muscle spasms from multiple sclerosis or spinal cord injuries in adults and children ages 12 years and older. This medication is taken by mouth, typically 3 times a day. Baclofen comes as tablets, as well as oral solutions (including brand names Ozobax DS and Fleqsuvy) and dissolvable granules (brand name Lyvispah) for people who've trouble swallowing tablets. Side effects of baclofen include sleepiness, dizziness, and nausea. If you stop this medication too suddenly, you might experience withdrawal symptoms.
What is Baclofen?
What is Baclofen used for?
- Muscle spasms from multiple sclerosis or spinal cord injuries in people ages 12 years and older
How Baclofen works
Baclofen is a muscle relaxant. The way it works isn't well-understood. Some research suggests it works by relaxing the nerves that make your muscles tighten or cramp up.
When does Baclofen start working?Time passed since treatment started:
Drug facts
| Common Brands | Ozobax DS, Fleqsuvy, Lyvispah |
|---|---|
| Drug Class | Muscle relaxant |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Baclofen
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sleepiness (up to 63%)
- Dizziness (up to 15%)
- Weakness (up to 15%)
- Nausea (up to 12%)
- Confusion (up to 11%)
Less Common Side Effects
- Headache
- General feeling of low energy
- Constipation
- More frequent urination
- Trouble sleeping
- Metallic taste in your mouth
Baclofen serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Extreme sleepiness
When do Baclofen possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Drowsiness
Dizziness
More on Baclofen side effects
The following Baclofen side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common or rare
Bloody or dark urine
fainting
mental depression or other mood changes
ringing or buzzing in the ears
seeing or hearing things that are not there
skin rash or itching
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Blurred vision
convulsions
difficult or troubled breathing
dizziness
drowsiness
irregular, fast or slow, or shallow breathing
lightheadedness
loss of strength or energy
muscle pain or weakness
pale or blue lips, fingernails, or skin
sleepiness or unusual drowsiness
unusual weak feeling
unusually slow or troubled breathing
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Confusion
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
headache
increased need to urinate
passing urine more often
sweating
trouble sleeping
unusual tiredness or weakness
Less common or rare
Abdominal or stomach pain or discomfort
clumsiness, unsteadiness, trembling, or other problems with muscle control
false sense of well-being
loss of appetite
muscle or joint pain
numbness or tingling in the hands or feet
pounding heartbeat
slurred speech or other speech problems
swelling of the ankles
unexplained muscle stiffness
unusual excitement
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$34.72
GoodRx discount
$11.16
Pros and cons of Baclofen
Pros
- Starts to work quickly
- Can take with or without food
- Tablets and some liquid formulations are available as lower-cost generics
- Can crush or cut tablets
Cons
- Sleepiness is a common side effect
- Oral granules are available as a brand-name only
- Can cause withdrawal symptoms if stopped too quickly
- Might not be safe while pregnant
Pharmacist tips for Baclofen
- Take baclofen exactly as prescribed to you. Don't change your dose or suddenly stop taking baclofen without talking to your healthcare professional (HCP) first. Doing so can cause withdrawal symptoms, like nausea, muscle spasms, and fever. Follow your prescriber's instructions to lower your dose slowly over a period of time to stop the medication safely.
- You can take baclofen with or without food. But some people experience nausea with baclofen, so taking it with food might help.
- Let your care team know if you've had a stroke in the past because baclofen might not work well for you. Your healthcare prescriber will recommend other options to treat your muscle spasms.
- Baclofen can make you sleepy and dizzy. Don't drive or do anything requiring concentration until you know how this medication affects you.
- Don't drink alcohol while taking baclofen because it can worsen sleepiness. If avoiding alcohol isn't possible for you, talk to your prescriber about other medication options for you, or ways to get help to quit alcohol. More tips for baclofen tablets
- If you need to cut the baclofen tablet in half, use a pill splitter instead of a knife. The tablets have a scored line on them to help you cut your tablet in half. This will help make sure you split the tablet evenly and safely. More tips for baclofen oral solution
- Baclofen oral solutions come in different concentrations, including a concentrated version that contains 5 mL of baclofen in each mL of medication. Always check the label of your medication bottle to make sure you're measuring out the right amount for your dose based on the total dose in milligrams.
- Only use the measuring device provided at the pharmacy to measure out your dose of baclofen. Don't use household spoons to measure your dose since this could cause you to take the wrong amount. More tips for Lyvispah oral granules
- You can empty the entire contents of the Lyvispah packet directly into your mouth. The granules will immediately dissolve and can be swallowed. Or, you can mix it with up to 15 mL (a tablespoonful) of liquids or soft foods (e.g., apple sauce, yogurt, pudding). Take the dose within 2 hours after mixing with liquid or food.
Risks and warnings for Baclofen
Baclofen can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Withdrawal symptoms
- Risk factors: Taking baclofen for a long time | Stopping baclofen suddenly | Newborns whose mothers took baclofen during pregnancy
If you've taken baclofen for a long period of time and you suddenly stop taking it, you can experience serious withdrawal symptoms, like tremor, muscle stiffness, or seizures. Talk to your healthcare team if you'd like to stop taking baclofen. They can help you lower your dose safely.
Extreme sleepiness or dizziness
- Risk factors: Taking with alcohol or illicit drugs | Taking other medications that cause drowsiness | People over 65
Taking baclofen can make you feel sleepy and dizzy. These side effects can affect your ability to think, concentrate, and focus. Don't drink alcohol or take other medications that cause sleepiness or dizziness while taking baclofen because it can make these side effects worse. Avoid activities that require you to be alert, like driving or operating machinery, until you know how the medication affects you.
Worsening of other health conditions
Make sure to tell your care team about all of your medical conditions before starting baclofen because it can worsen the symptoms of certain conditions. Examples include mental health problems (e.g., schizophrenia), high blood pressure due to spinal cord injury (autonomic dysreflexia), seizures and people who need muscle tone for posture or balance.
Don't take during pregnancy
If you're pregnant, talk with your healthcare team before taking baclofen. This medication hasn't been well-studied during human pregnancy, but animal studies suggest that it might cause birth defects in unborn babies. In addition, babies born to mothers who took baclofen throughout pregnancy also experienced withdrawal symptoms at birth. Because of these risks, people who are pregnant shouldn't take baclofen unless they and their healthcare team decide the benefit of this medication is greater than its potentially risk for harm.
Baclofen dosage
The average cost for 60 tablets of 10mg of Baclofen is $11.16 with a free GoodRx coupon. This is 67.86% off the average retail price of $34.72. 
Bottle of oral solution
Bottle of oral solution| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 237ml of 10mg/5ml | 1 bottle | $200.24 | $200.24 |
| 473ml of 10mg/5ml | 1 bottle | $395.16 | $395.16 |
| 473ml of 5mg/5ml | 1 bottle | $160.91 | $160.91 |
Typical dosage for Baclofen
Baclofen comes in many formulations, including tablets, dissolvable granules, and oral solutions of various strengths (e.g., baclofen 1 mg/mL, baclofen 2 mg/mL, and baclofen 5 mg/mL).
The typical dose ranges from 5 mg to 20 mg by mouth three times a day. The maximum dose is 20 mg four times a day.
Your prescriber will usually start with a low dose and slowly raise it based on how well the medication works for you and as long as you're not having side effects.
Your dose might be different if you have kidney problems.
More on Baclofen dosage
Interactions between Baclofen and other drugs
Baclofen may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Baclofen. Please note that only the generic name of each medication is listed below.
More on Baclofen interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alfentanil
- Alprazolam
- Amifampridine
- Benzhydrocodone
- Bromazepam
- Buprenorphine
- Butorphanol
- Calcium Oxybate
- Cannabidiol
- Cetirizine
- Clobazam
- Codeine
- Dihydrocodeine
- Donepezil
- Doxylamine
- Esketamine
- Fentanyl
- Flibanserin
- Gabapentin
- Gabapentin Enacarbil
- Hydrocodone
- Hydromorphone
- Ketamine
- Lemborexant
- Levocetirizine
- Levorphanol
- Lofexidine
- Loxapine
- Magnesium Oxybate
- Meperidine
- Methadone
- Metoclopramide
- Midazolam
- Morphine
- Morphine Sulfate Liposome
- Nalbuphine
- Oxycodone
- Oxymorphone
- Pentazocine
- Periciazine
- Potassium Oxybate
- Pregabalin
- Remifentanil
- Remimazolam
- Scopolamine
- Sodium Oxybate
- Sufentanil
- Tapentadol
- Tramadol
- Trazodone
- Zolpidem
How much does Baclofen cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
What are alternatives to Baclofen?
There are a number of medications that your doctor can prescribe in place of Baclofen. Compare a few possible alternatives below.
News about Baclofen
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8 Baclofen Side Effects You Should Know About
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