Key takeaways
Metoprolol succinate (Toprol XL) and clonidine (Catapres, Nexiclon XR) are both used to manage high blood pressure, but they work differently and have different uses. Metoprolol succinate is a selective beta blocker that mainly affects the heart, slowing down your heart rate and lowering blood pressure. It is also used to treat chest pain and reduce the risk of hospitalization and death in heart failure. Clonidine, on the other hand, is an alpha agonist that works in the brain to lower stress hormones, which slows your heart rate and relaxes blood vessels. Clonidine is available in oral and topical forms, while metoprolol succinate is taken orally. Clonidine is not usually a first-choice treatment for high blood pressure because it can cause rebound hypertension if stopped suddenly, and it is not recommended for older adults due to the risk of falls. Metoprolol succinate is typically taken once daily with food, whereas clonidine can be taken as a tablet multiple times a day or applied as a patch once a week. Both medications can cause dizziness and tiredness, but clonidine is more likely to cause dry mouth and drowsiness.
