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Toprol XL vs. Betapace

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Metoprolol succinate (Toprol XL) and sotalol (Betapace) are both medications used to treat heart conditions, but they have different uses and properties. Metoprolol succinate is a selective beta blocker primarily used to treat high blood pressure, chest pain, and to lower the risk of hospitalization and death in heart failure. It is taken once daily and is available in both generic and brand name forms. On the other hand, sotalol is a non-selective beta blocker and potassium channel blocker used to treat and prevent certain heart rhythm problems like atrial fibrillation. Sotalol is typically taken twice daily and also comes in both generic and brand name forms. Unlike metoprolol, starting sotalol usually requires a hospital stay for monitoring due to the risk of serious side effects. Both medications can cause dizziness and tiredness, but sotalol has a higher risk of causing breathing problems and requires careful monitoring of heart rhythm. Additionally, metoprolol needs to be taken with food, while sotalol can be taken with or without food but should be consistent.

Metoprolol succinate

(Toprol XL)

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Sotalol

(Betapace)

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Summary for Toprol XL

Prescription only

Metoprolol succinate (Toprol XL) is used to treat hypertension and to control chronic (long-term) chest pain. It's also used to lower the risk for hospitalization and death in people with heart failure. Metoprolol succinate (Toprol XL) is the extended-release version of metoprolol tartrate (Lopressor), but keep in mind the two versions don't treat the exact same conditions. And because metoprolol succinate (Toprol XL) is longer-acting, it's taken by mouth typically taken just once daily. Some common side effects of metoprolol succinate (Toprol XL) include tiredness or dizziness.

Indications for Toprol XL

  • High blood pressure
  • Chest pain (angina)
  • Lower the risk of hospitalization and death in heart failure

Pros and Cons for Toprol XL

Pros

  • A first-choice option to prevent chest pains (angina)
  • A first-choice option for heart failure
  • Only needs to be taken once a day
  • Available as capsules (Kapspargo) that can be opened and sprinkled on soft foods, good for people who've trouble swallowing pills

Cons

Common Side Effects for Toprol XL

  • Tiredness
  • Dizziness
  • Depression
  • Diarrhea
  • Trouble catching your breath
  • Drop in heart rate
  • Rash

Please note: The side effects above occurred in 2% or more of people taking metoprolol succinate (Toprol XL).

Warnings for Toprol XL

  • Heart problems after suddenly stopping the medication
  • Worsened symptoms of heart failure
  • Risk of difficulty breathing
  • Rise in blood pressure in people with pheochromocytoma
  • Greater risk during surgery
  • Hiding symptoms of low blood sugar
  • Masked symptoms of overactive thyroid

Summary for Betapace

Prescription only

Sotalol (Betapace) is used to treat and prevent certain types of heart rate and heart rhythm problems (like atrial fibrillation or Afib). It's taken by mouth, typically twice a day. Usually, you need to start this medication in the hospital and stay there for at least 3 days so that the healthcare team can monitor your heart rhythm and check for any serious side effects. Sotalol (Betapace) can interact with several medications, including certain blood pressure medications and antacids. Sotalol is available both generic and brand name medications.

Indications for Betapace

Pros and Cons for Betapace

Pros

  • Works well to treat life-threatening arrhythmias
  • Available in a lower-cost, generic version
  • Available as an oral liquid for people having trouble swallowing tablets

Cons

  • Must in a hospital for 3 days when first starting
  • Can cause serious arrhythmias, so it requires close monitoring
  • Can't use in people with certain medical conditions (e.g., heart failure, severe kidney problems, breathing problems)

Common Side Effects for Betapace

  • Tiredness (up to 20%)
  • Dizziness (up to 16%)
  • Low heart rate (up to 13%)
  • Headache (up to 12%)
  • Trouble breathing (up to 10%)

Warnings for Betapace

  • Life-threatening abnormal heart rhythm
  • Low blood pressure and heart rate
  • Heart failure
  • Difficulty breathing (bronchospasm)
  • Masked symptoms of low blood sugar
  • Heart issues with sudden discontinuation
  • Severe allergic reactions

Prices with our coupons for Toprol XL vs. Betapace

Price Card Drug Icon
Metoprolol ER90 tablets / 25mg
$15.75$101.54
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Sotalol60 tablets / 80mg
$14.74$42.60
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