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Enalapril vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Enalapril (Vasotec) and Metoprolol succinate (Toprol XL) are both used to treat high blood pressure, but they belong to different medication classes and have distinct mechanisms of action. Enalapril is an ACE inhibitor that works by relaxing blood vessels, while Metoprolol succinate is a beta blocker that slows down the heart rate. Enalapril is also approved for heart failure and can be taken by children as young as 1 month old, whereas Metoprolol succinate is used to control chronic chest pain and lower the risk of hospitalization and death in heart failure, and is only approved for children 6 years and older. Enalapril is typically taken once or twice daily, while Metoprolol succinate is taken once daily. Common side effects of Enalapril include tiredness, dizziness, and cough, whereas Metoprolol succinate can cause tiredness, dizziness, and depression. Enalapril should not be used during pregnancy, while Metoprolol succinate should not be stopped suddenly due to the risk of heart problems.

Enalapril

(Vasotec)

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Metoprolol succinate

(Toprol XL)

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Summary for Enalapril

Prescription only

Enalapril (Vasotec) is a first-choice medication used for treating high blood pressure. It's also approved for heart failure. Enalapril (Vasotec) belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It's taken by mouth, once or twice daily. Enalapril (Vasotec) doesn't cause many side effects, but some include tiredness, dizziness, and cough.

Indications for Enalapril

  • High blood pressure
  • Heart failure

Pros and Cons for Enalapril

Pros

  • A first-choice blood pressure lowering medication for many people
  • Taken by mouth
  • Can be taken by children as young as 1 month old (high blood pressure only)
  • Available as a liquid for people who have trouble swallowing pills

Cons

Common Side Effects for Enalapril

  • Feeling tired (3%)

Warnings for Enalapril

  • Not for use during pregnancy
  • Angioedema (swelling)
  • Low blood pressure
  • Worsening kidney problems
  • Heart problems due to high potassium
  • Liver problems

Summary for Toprol XL

Prescription only

Metoprolol succinate (Toprol XL) is used to treat hypertension and to control chronic (long-term) chest pain. It's also used to lower the risk for hospitalization and death in people with heart failure. Metoprolol succinate (Toprol XL) is the extended-release version of metoprolol tartrate (Lopressor), but keep in mind the two versions don't treat the exact same conditions. And because metoprolol succinate (Toprol XL) is longer-acting, it's taken by mouth typically taken just once daily. Some common side effects of metoprolol succinate (Toprol XL) include tiredness or dizziness.

Indications for Toprol XL

  • High blood pressure
  • Chest pain (angina)
  • Lower the risk of hospitalization and death in heart failure

Pros and Cons for Toprol XL

Pros

  • A first-choice option to prevent chest pains (angina)
  • A first-choice option for heart failure
  • Only needs to be taken once a day
  • Available as capsules (Kapspargo) that can be opened and sprinkled on soft foods, good for people who've trouble swallowing pills

Cons

Common Side Effects for Toprol XL

  • Tiredness
  • Dizziness
  • Depression
  • Diarrhea
  • Trouble catching your breath
  • Drop in heart rate
  • Rash

Please note: The side effects above occurred in 2% or more of people taking metoprolol succinate (Toprol XL).

Warnings for Toprol XL

  • Heart problems after suddenly stopping the medication
  • Worsened symptoms of heart failure
  • Risk of difficulty breathing
  • Rise in blood pressure in people with pheochromocytoma
  • Greater risk during surgery
  • Hiding symptoms of low blood sugar
  • Masked symptoms of overactive thyroid

Prices with our coupons for Enalapril vs. Toprol XL

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Enalapril60 tablets / 20mg
$17.20$53.10
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Metoprolol ER90 tablets / 25mg
$15.75$101.54
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