Key takeaways
Enalapril (Vasotec) and Chlorthalidone (Thalitone) are both used to treat high blood pressure, but they belong to different medication classes and work in different ways. Enalapril is an ACE inhibitor that relaxes blood vessels by blocking a protein, while Chlorthalidone is a diuretic (water pill) that helps you urinate more to remove extra water and certain electrolytes. Enalapril is also approved for heart failure, whereas Chlorthalidone is used to relieve swelling from conditions like heart failure, kidney problems, and liver problems. Enalapril can be taken by children as young as 1 month old, but Chlorthalidone is typically prescribed for adults. Common side effects of Enalapril include tiredness, dizziness, and cough, while Chlorthalidone often causes more frequent urination, dizziness, and headache. Enalapril is not safe during pregnancy, and Chlorthalidone can cause electrolyte imbalances and is not recommended for people with a sulfa allergy.
