Key takeaways
Felodipine ER (Plendil) and nimodipine (Nymalize) are both calcium channel blockers, but they are used for different purposes. Felodipine ER is primarily used to treat high blood pressure in adults and is taken once daily. In contrast, nimodipine is used to prevent brain damage after a specific type of brain bleed called an aneurysmal subarachnoid hemorrhage and is taken every 4 hours for 3 weeks. Felodipine ER is available only as a tablet, while nimodipine comes in both capsule and liquid forms. Common side effects of felodipine ER include swelling, headache, and flushing, whereas nimodipine commonly causes low blood pressure and can also cause diarrhea and rash. Additionally, felodipine ER with or without food, while nimodipine must be taken on an empty stomach. Both medications can interact with grapefruit, so you should avoid grapefruit products while taking them.
