Key takeaways
Zestoretic (lisinopril/hydrochlorothiazide) and valsartan (Diovan) are both used to treat high blood pressure, but they belong to different medication classes. Zestoretic is a combination of an ACE inhibitor (lisinopril) and a diuretic (hydrochlorothiazide), while valsartan is an angiotensin II receptor blocker (ARB). Zestoretic works by relaxing blood vessels and removing extra water and electrolytes through the kidneys, whereas Valsartan lowers blood pressure by blocking a hormone that tightens blood vessels. Zestoretic is typically taken once daily, while valsartan can be taken once or twice daily depending on the condition being treated. Both medications can cause dizziness, but Zestoretic is more likely to cause a dry cough. Valsartan is available in both tablet and liquid forms, while Zestoretic is only available as a tablet. Both medications come as lower-cost generics but are not safe to use during pregnancy.
