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Compare Plendil vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Felodipine er (Plendil)
    Zestoretic (lisinopril / hydrochlorothiazide)
  • Felodipine er (Plendil)
    Zestoretic (lisinopril / hydrochlorothiazide)

  • Summary of Plendil vs. Zestoretic

    Summary for Calcium channel blocker (CCB)
    Prescription only

    Felodipine ER (Plendil) is a calcium channel blocker. It lowers blood pressure by relaxing your blood vessels. This medication is one of the first-choice options for treating high blood pressure in adults. It's taken by mouth, typically once daily. Some side effects of this medication include swelling, headache, and flushing. Brand name Plendil has been discontinued.

    Summary for ACE inhibitor/Diuretic (water pill) combo
    Prescription only

    Zestoretic is a combination blood pressure medication for adults. It contains lisinopril (an angiotensin-converting enzyme (ACE) inhibitor) and hydrochlorothiazide (a thiazide diuretic). It comes as a tablet that's taken by mouth once per day. Your prescriber will determine your dosage based on how high your blood pressure is and if you're taking other blood pressure medications. Some of the more common side effects it can cause include dizziness, headache, and cough. Zestoretic (lisinopril / hydrochlorothiazide) is available as a generic.

  • Indications of Plendil vs. Zestoretic

    Indications for
    •High blood pressure (hypertension)
    Indications for
    •High blood pressure in adults

  • Pros and Cons of Plendil vs. Zestoretic

    Pros and Const for Calcium channel blocker (CCB)
    Pros
    •Taken by mouth
    •Taken once daily
    •Available as a lower-cost generic medication
    Cons
    •Only available as a tablet
    •Not a good choice if you've heart failure
    •Not recommended in pregnancy
    Pros and Const for ACE inhibitor/Diuretic (water pill) combo
    Pros
    •Combines two medications in one pill
    •Taken by mouth
    •Taken once daily
    Cons
    •Can make you urinate more often
    •Might not be appropriate for someone with a sulfa allergy
    •Shouldn't take during pregnancy or breastfeeding

  • Common Side Effects of Plendil vs. Zestoretic

    Common Side Effects for
    •Swelling in the arms, hands, legs, or feet (up to 17%)
    •Headache (up to 15%)
    •Flushing (up to 7%)
    Common Side Effects for
    •Dizziness (8%)
    •Headache (5%)
    •Cough (4%)
    •Extreme tiredness (4%)
    •Feeling lightheaded when standing after sitting or lying down (3%)

  • Warnings of Plendil vs. Zestoretic

    Common Side Effects for
    •Severely low blood pressure
    •Caution with heart failure
    •Swelling
    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Kidney damage
    •Changes in electrolyte, blood sugar, and cholesterol levels
    •Vision problems
    •Lupus

  • Prices with our coupons for Plendil vs. Zestoretic

    Learn more about Felodipine er
    Learn more about Zestoretic

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