Key takeaways
Telmisartan (Micardis) and Zestoretic (lisinopril/hydrochlorothiazide) are both medications used to treat high blood pressure, but they work in different ways. Telmisartan is an angiotensin II receptor blocker (ARB) that relaxes blood vessels by blocking a hormone that narrows them. Zestoretic combines an angiotensin-converting enzyme (ACE) inhibitor, lisinopril, which also relaxes blood vessels, with a diuretic (water pill), hydrochlorothiazide, which helps remove extra water and salt from your body. Telmisartan is typically taken once a day and is available as a generic medication, while Zestoretic is also taken once daily but combines two medications in one pill. Common side effects of telmisartan include upper respiratory infections and back pain, whereas Zestoretic can cause dizziness, headache, and a dry cough. Both medications are not safe for use during pregnancy and may require regular blood work to monitor kidney function and electrolyte levels.
