Key takeaways
Hyzaar (losartan/hydrochlorothiazide) and Exforge (amlodipine/valsartan) are both combination medications used to treat high blood pressure, but they work in different ways. Hyzaar combines an angiotensin II receptor blocker (ARB) with a diuretic, while Exforge combines an ARB with a calcium channel blocker (CCB). Hyzaar is typically prescribed for those who have already been taking its individual components separately, whereas Exforge is often used for convenience if you are already on stable doses of amlodipine and valsartan. Hyzaar can cause increased urination due to its diuretic component, while Exforge may cause swelling in the arms and legs due to amlodipine. Both medications are taken once daily and are available in generic forms. However, neither is safe to use during pregnancy or breastfeeding.
