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Compare Hyzaar vs. Exforge

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Hyzaar (losartan/hydrochlorothiazide) and Exforge (amlodipine/valsartan) are both combination medications used to treat high blood pressure, but they work in different ways. Hyzaar combines an angiotensin II receptor blocker (ARB) with a diuretic, while Exforge combines an ARB with a calcium channel blocker (CCB). Hyzaar is typically prescribed for those who have already been taking its individual components separately, whereas Exforge is often used for convenience if you are already on stable doses of amlodipine and valsartan. Hyzaar can cause increased urination due to its diuretic component, while Exforge may cause swelling in the arms and legs due to amlodipine. Both medications are taken once daily and are available in generic forms. However, neither is safe to use during pregnancy or breastfeeding.

  • Hyzaar (losartan / hydrochlorothiazide)
    Exforge (amlodipine / valsartan)
  • Hyzaar (losartan / hydrochlorothiazide)
    Exforge (amlodipine / valsartan)

  • Summary of Hyzaar vs. Exforge

    Summary for ARB / Diuretic (water pill) combo
    Prescription only

    Hyzaar (losartan / hydrochlorothiazide) is a combination medication that contains two first-choice options for lowering blood pressure. This medication is taken by mouth once daily. Like other blood pressure medications, Hyzaar (losartan / hydrochlorothiazide) can cause you to feel dizzy, especially when you first start this medication or when your provider raises your dose.

    Summary for CCB / ARB
    Prescription only

    Exforge is a combination blood pressure medication for adults. It contains amlodipine (a calcium channel blocker, or CCB) and valsartan (an angiotensin receptor blocker, or ARB). It comes as a tablet that's taken by mouth, typically once per day. Some side effects of Exforge (amlodipine / valsartan) include swelling throughout the body and dizziness. This medication is available as generics.

  • Indications of Hyzaar vs. Exforge

    Indications for
    •High blood pressure
    •Lower the risk of stroke in people with high blood pressure and an enlarged left ventricle of the heart
    Indications for
    •High blood pressure in adults

  • Pros and Cons of Hyzaar vs. Exforge

    Pros and Const for ARB / Diuretic (water pill) combo
    Pros
    •Contains two first-choice blood pressure medications
    •Convenient to take a combination of two medications in one pill taken just once a day
    •Protects your kidneys, which is especially useful for people with diabetes or mild-to-moderate kidney disease
    •Taken by mouth once per day
    Cons
    •Can make you urinate more often
    •Must be avoided in pregnant females
    •More difficult to customize the dose since Hyzaar (losartan / hydrochlorothiazide) is a combination of two medications
    •Only available as a tablet
    Pros and Const for CCB / ARB
    Pros
    •Convenient to take a combination of two medications in one pill
    •Only taken once a day
    •Available as a lower-cost generic
    Cons
    •Not safe to take while pregnant or breastfeeding
    •Might not be a good choice for people with liver problems
    •Can cause swelling in the arms and legs

  • Common Side Effects of Hyzaar vs. Exforge

    Common Side Effects for
    •Upper respiratory tract infection (i.e., common cold; 6%)
    •Dizziness (6%)
    •Back pain (2%)
    Common Side Effects for
    •Swelling in legs or arms (5%)
    •Sore throat, runny nose, and other cold-like symptoms (3-4%)
    •Dizziness (2%)

  • Warnings of Hyzaar vs. Exforge

    Common Side Effects for
    •Not for use during pregnancy
    •Low blood pressure
    •Kidney damage
    •Changes in electrolyte, blood sugar, and cholesterol levels
    •Vision problems
    •Lupus
    Common Side Effects for
    •Harm to unborn baby
    •Low blood pressure
    •Risk of heart attack or chest pain
    •Possible kidney damage in certain people
    •High potassium levels

  • Prices with our coupons for Hyzaar vs. Exforge

    Learn more about Hyzaar
    Learn more about Exforge

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