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Compare Zestoretic vs. Coreg

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Zestoretic (lisinopril/hydrochlorothiazide) and carvedilol (Coreg) are both used to treat high blood pressure, but they belong to different medication classes and have different mechanisms of action. Zestoretic combines lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, with hydrochlorothiazide, a diuretic. It works by relaxing blood vessels and removing excess water and electrolytes from your body. Carvedilol, on the other hand, is a beta blocker that lowers blood pressure by relaxing blood vessels and slowing down your heart rate. Zestoretic is typically taken once daily, while carvedilol is taken twice daily in its immediate-release form or once daily in its extended-release form. Carvedilol is also used to manage heart failure and reduce the risk of death after a heart attack, whereas Zestoretic is primarily focused on lowering blood pressure. Common side effects of Zestoretic include dizziness, headache, and cough, while carvedilol can cause dizziness, tiredness, and diarrhea. Additionally, carvedilol should not be taken if you have asthma or certain heart conditions, whereas Zestoretic is not safe for use during pregnancy.

  • Zestoretic (lisinopril / hydrochlorothiazide)
    Carvedilol (Coreg)
  • Zestoretic (lisinopril / hydrochlorothiazide)
    Carvedilol (Coreg)

  • Summary of Zestoretic vs. Coreg

    Summary for ACE inhibitor/Diuretic (water pill) combo
    Prescription only

    Zestoretic is a combination blood pressure medication for adults. It contains lisinopril (an angiotensin-converting enzyme (ACE) inhibitor) and hydrochlorothiazide (a thiazide diuretic). It comes as a tablet that's taken by mouth once per day. Your prescriber will determine your dosage based on how high your blood pressure is and if you're taking other blood pressure medications. Some of the more common side effects it can cause include dizziness, headache, and cough. Zestoretic (lisinopril / hydrochlorothiazide) is available as a generic.

    Summary for Beta blocker
    Prescription only

    Carvedilol (Coreg) is used to treat high blood pressure, manage heart failure, and help with heart problems after a heart attack. It belongs to the beta blocker drug class. This medication comes as a tablet that's taken by mouth twice daily, and as an oral extended-release (ER) capsule (brand name Coreg CR) that's taken once daily. Common side effects include dizziness, feeling tired, and diarrhea.

  • Indications of Zestoretic vs. Coreg

    Indications for
    •High blood pressure in adults
    Indications for
    •High blood pressure
    •Heart failure
    •Lower the risk of death from heart-related problems after a heart attack

  • Pros and Cons of Zestoretic vs. Coreg

    Pros and Const for ACE inhibitor/Diuretic (water pill) combo
    Pros
    •Combines two medications in one pill
    •Taken by mouth
    •Taken once daily
    Cons
    •Can make you urinate more often
    •Might not be appropriate for someone with a sulfa allergy
    •Shouldn't take during pregnancy or breastfeeding
    Pros and Const for Beta blocker
    Pros
    •Taken by mouth
    •Comes as a once-daily extended-release formulation
    •Dose can be adjusted based on your response
    •Available as a lower-cost generic
    Cons
    •Need to take with food
    •Can cause you to feel more tired
    •Can cause dry eyes if you wear contact lenses
    •Shouldn't be taken if you have asthma or an asthma-related condition

  • Common Side Effects of Zestoretic vs. Coreg

    Common Side Effects for
    •Dizziness (8%)
    •Headache (5%)
    •Cough (4%)
    •Extreme tiredness (4%)
    •Feeling lightheaded when standing after sitting or lying down (3%)
    Common Side Effects for
    •Dizziness (6%)

    Please note: These side effects were reported by people who took carvedilol (Coreg) in clinical studies for high blood pressure.

  • Warnings of Zestoretic vs. Coreg

    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Kidney damage
    •Changes in electrolyte, blood sugar, and cholesterol levels
    •Vision problems
    •Lupus
    Common Side Effects for
    •Worsening chest pain and heart attacks
    •Slow heart rate and low blood pressure
    •Heart failure
    •Hiding symptoms of low blood sugar
    •Risk of difficulty breathing
    •Hiding symptoms of high thyroid hormone
    •Risk of kidney problems
    •Severe allergic reactions
    •Greater risk during surgery
    •Risk of eye problems during surgery

  • Prices with our coupons for Zestoretic vs. Coreg

    Learn more about Zestoretic
    Learn more about Carvedilol

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