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Compare Zestoretic vs. Lopressor

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Zestoretic (lisinopril/hydrochlorothiazide) and metoprolol tartrate (Lopressor) are both used to treat high blood pressure, but they work in different ways and have different uses. Zestoretic is a combination of an ACE inhibitor and a diuretic, which helps relax blood vessels and remove extra water and electrolytes from your body. It's typically taken once daily. Metoprolol tartrate, on the other hand, is a beta blocker that slows down your heart rate and is usually taken twice daily. Besides high blood pressure, metoprolol tartrate is also used to treat chest pain and lower the risk of death after a heart attack. Zestoretic is not safe for use during pregnancy, while metoprolol tartrate can be an option for breastfeeding mothers. Common side effects of Zestoretic include dizziness and cough, whereas metoprolol tartrate can cause tiredness and dizziness. Both medications are available in generic forms, making them more affordable options.

  • Zestoretic (lisinopril / hydrochlorothiazide)
    Metoprolol tartrate (Lopressor)
  • Zestoretic (lisinopril / hydrochlorothiazide)
    Metoprolol tartrate (Lopressor)

  • Summary of Zestoretic vs. Lopressor

    Summary for ACE inhibitor/Diuretic (water pill) combo
    Prescription only

    Zestoretic is a combination blood pressure medication for adults. It contains lisinopril (an angiotensin-converting enzyme (ACE) inhibitor) and hydrochlorothiazide (a thiazide diuretic). It comes as a tablet that's taken by mouth once per day. Your prescriber will determine your dosage based on how high your blood pressure is and if you're taking other blood pressure medications. Some of the more common side effects it can cause include dizziness, headache, and cough. Zestoretic (lisinopril / hydrochlorothiazide) is available as a generic.

    Summary for Beta blocker
    Prescription only

    Metoprolol tartrate (Lopressor) is used to treat chest pain and high blood pressure. It's also used to lower the risk of death after a heart attack. This medication is taken by mouth, typically twice daily, though your dosage depends on what condition you have. Some side effects of metoprolol tartrate (Lopressor) include dizziness or tiredness. Metoprolol tartrate (Lopressor) is available as a brand name and generic tablet.

  • Indications of Zestoretic vs. Lopressor

    Indications for
    •High blood pressure in adults
    Indications for
    •High blood pressure
    •Chest pain (angina)
    •Lower risk of death after heart attack

  • Pros and Cons of Zestoretic vs. Lopressor

    Pros and Const for ACE inhibitor/Diuretic (water pill) combo
    Pros
    •Combines two medications in one pill
    •Taken by mouth
    •Taken once daily
    Cons
    •Can make you urinate more often
    •Might not be appropriate for someone with a sulfa allergy
    •Shouldn't take during pregnancy or breastfeeding
    Pros and Const for Beta blocker
    Pros
    •First choice treatment to prevent chest pain (angina)
    •First choice treatment for people who've had a heart attack because it lowers the risk of death
    •A possible option for mothers who are breastfeeding
    •Less likely to cause breathing problems than with other beta blockers
    •Available as a lower-cost generic version
    Cons
    •Need to take with food
    •Need to take more than once a day
    •Not a first-choice treatment for high blood pressure, unless you have heart failure or heart disease
    •Can hide symptoms of low blood sugar
    •Stopping too suddenly can raise the risk of heart attack and stroke

  • Common Side Effects of Zestoretic vs. Lopressor

    Common Side Effects for
    •Dizziness (8%)
    •Headache (5%)
    •Cough (4%)
    •Extreme tiredness (4%)
    •Feeling lightheaded when standing after sitting or lying down (3%)
    Common Side Effects for
    •Tiredness (10%)
    •Dizziness (10%)
    •Diarrhea (5%)
    •Rash (5%)
    •Depression (5%)

  • Warnings of Zestoretic vs. Lopressor

    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Kidney damage
    •Changes in electrolyte, blood sugar, and cholesterol levels
    •Vision problems
    •Lupus
    Common Side Effects for
    •Worsening chest pain and heart attacks
    •Heart failure
    •Slow heart rate
    •Hiding symptoms of low blood sugar
    •Hiding symptoms of overactive thyroid
    •Greater risk during surgery
    •Risk of difficulty breathing

  • Prices with our coupons for Zestoretic vs. Lopressor

    Learn more about Zestoretic
    Learn more about Metoprolol tartrate

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