Key takeaways
Nifedipine ER (Procardia XL) and Zestoretic (lisinopril/hydrochlorothiazide) are both used to treat high blood pressure, but they work in different ways and belong to different drug classes. Nifedipine ER is a calcium channel blocker (CCB) that relaxes blood vessels to improve blood flow and is also used to treat chest pain (angina). It is available in both extended-release and immediate-release forms, though the latter is rarely prescribed due to more side effects. On the other hand, Zestoretic combines an angiotensin-converting enzyme (ACE) inhibitor (lisinopril) and a diuretic (hydrochlorothiazide) to lower blood pressure by relaxing blood vessels and removing excess water and electrolytes through the kidneys. Zestoretic is taken once daily and is known to cause a dry cough, a common side effect of ACE inhibitors, whereas nifedipine ER can cause swelling in the legs and feet. Additionally, Zestoretic is not safe for use during pregnancy, while nifedipine ER is considered one of the recommended medications for high blood pressure in pregnancy. Both medications are available in generic forms, making them more affordable options.
