Key takeaways
Felodipine ER (Plendil) and prazosin (Minipress) are both medications used to treat high blood pressure, but they belong to different drug classes and have distinct characteristics. Felodipine ER is a calcium channel blocker that works by relaxing your blood vessels and is typically taken once daily. In contrast, prazosin is an alpha blocker that also relaxes blood vessels but is usually taken 2 to 3 times a day. Felodipine ER can be a first-choice option for treating high blood pressure, while prazosin is not due to its bothersome side effects like dizziness and drowsiness. Additionally, both medications are available as a lower-cost generic medications. Prazosin is also used off-label for PTSD-related nightmares. Common side effects of felodipine ER include swelling, headache, and flushing, while prazosin can cause dizziness, headache, and drowsiness. Both medications should be taken with caution, especially in older adults, and you should avoid alcohol while taking them to prevent worsening side effects.
