9 Prazosin Side Effects and How to Manage Them
Prazosin is a high blood pressure medication that can cause low blood pressure. Other possible prazosin side effects include drowsiness, fatigue, and nausea.
prazosin
Used for Hypertension
Used for Hypertension
Prazosin (Minipress) is an alpha blocker that's used to lower high blood pressure. It works by relaxing your blood vessels, so blood flows through more easily. Prazosin (Minipress) is taken by mouth, typically 2 to 3 times a day. But it isn't a first-choice medication to lower blood pressure because it can cause bothersome side effects like dizziness, headache, and sleepiness.
What is Prazosin (Minipress)?
What is Prazosin (Minipress) used for?
- High blood pressure (hypertension)
How Prazosin (Minipress) works
Prazosin (Minipress) is an alpha blocker. It lowers blood pressure by relaxing blood vessels. This helps blood flow smoothly through the body.
When does Prazosin (Minipress) start working?Time passed since treatment started:
Drug facts
| Common Brands | Minipress |
|---|---|
| Drug Class | Alpha blocker |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Prazosin (Minipress)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Dizziness (10%)
- Headache (8%)
- Drowsiness (8%)
- Lack of energy (7%)
- Weakness (7%)
- Pounding heart (5%)
- Nausea (5%)
Less Common Side Effects
- Vomiting
- Diarrhea
- Constipation
- Swelling
- Trouble catching your breath
- Feeling faint
- Spinning sensation
- Depression
- Nervousness
- Rash
Prazosin (Minipress) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Priapism: painful erection that lasts more than 4 hours
When do Prazosin (Minipress) possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Dizziness
Headache
Drowsiness
Lack of energy
More on Prazosin (Minipress) side effects
The following Prazosin (Minipress) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Dizziness or lightheadedness, especially when getting up from a lying or sitting position
fainting (sudden)
Less common
Loss of bladder control
pounding heartbeat
swelling of the feet or lower legs
Incidence not known
Painful or prolonged erection of the penis
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Drowsiness
headache
lack of energy
Less common
Dryness of the mouth
nervousness
unusual tiredness or weakness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Prazosin (Minipress)
Pros
- Taken by mouth
- Can be taken with or without food
- Available as a lower-cost generic medication
Cons
- Not a first-choice option for lowering blood pressure
- Older adults are at higher risk for side effects, like dizziness or drowsiness
- Taken multiple times a day
Pharmacist tips for Prazosin (Minipress)
- Prazosin (Minipress) can make you feel dizzy or light-headed, especially when you start taking it for the first time and when your dose is raised. If you’ve been sitting or lying down, get up slowly to avoid the risk of falling.
- Because prazosin (Minipress) can cause dizziness, avoid driving and doing things that may be dangerous until your body gets used to the medication.
- Prazosin (Minipress) can raise your risk of falls since it causes dizziness. If you fall down and hit your head or are in pain after a fall, the safest choice is to seek medical care right away. This is because there could be bleeding inside the body, and it’s best to have your provider check for these injuries. This is particularly important if you’re taking blood thinners, which can raise your risk for bleeds that are difficult to stop.
- If your provider is adding on another blood pressure medication to prazosin (Minipress), they might lower your dose of prazosin (Minipress) to 1 mg or 2 mg three times a day. This is to lower your risk of the dizziness or fainting that might happen if your blood pressure drops too low. If needed, they'll raise your prazosin (Minipress) dose over time.
- If you want to stop taking prazosin (Minipress), let your provider know. Don't suddenly stop taking this medication. Doing so can cause your blood pressure to rise too quickly. Your provider can help you stop this medication safely by lowering the dose slowly over time.
Risks and warnings for Prazosin (Minipress)
Prazosin (Minipress) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Dangerously low blood pressure and risk of fainting
- Risk factors: Age 65 years or older | Taking other blood pressure medications | Drinking alcohol
Prazosin (Minipress) can cause you to feel dizzy or faint when you stand up after sitting or lying down. This is because your blood pressure might change quickly when you suddenly change positions (also known as orthostatic hypotension). The risk of this side effect is highest after your first dose of prazosin (Minipress), whenever your dose is raised, or when your provider add on another blood pressure medication. Typically, you tend to feel most dizzy within 90 minutes of taking a dose.
To minimize your risk of dizziness or fainting, you provider will have you start with a lower dose of prazosin (Minipress) and raise your dose slowly over time, if needed. Avoid activities that could be dangerous for the first 24 hours after you start prazosin (Minipress). This includes driving, operating heavy machinery, and exercising. If you feel dizzy, lightheaded, or like your heart is pounding, make sure to stop doing anything that could be hazardous. If these symptoms are bothersome, let your healthcare provider know because they might need to change your dose.
Painful erection (priapism)
In some rare cases, prazosin (Minipress) can cause a painful erection (also known as priapism) that continues for more than 4 hours. If this happens to you, contact your provider right away to avoid the risk of permanent erectile dysfunction.
Eye problems during surgery
- Risk factors: Cataract surgery
If you take prazosin (Minipress) and plan to get cataract eye surgery, let your provider know. In some rare cases, this medication can cause changes to your iris, a condition called Intraoperative Floppy Iris Syndrome (IFIS). Keep in mind that prazosin (Minipress) is probably less likely to cause IFIS than other similar medications, like tamsulosin (Flomax). You don’t need to stop taking prazosin (Minipress) before the surgery, but your surgeon needs to adjust how they perform the operation. Letting your provider know ahead of time can help them prepare accordingly.
Prazosin (Minipress) dosage
The average cost for 30 capsules of 1mg of Prazosin (Minipress) is $10.93 with a free GoodRx coupon. This is 55.42% off the average retail price of $24.52. 
Capsule
Capsule| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 1mg | 30 capsules | $10.93 | $0.36 |
| 2mg | 30 capsules | $9.02 | $0.30 |
| 5mg | 30 capsules | $16.64 | $0.55 |
Typical dosage for Prazosin (Minipress)
The typical starting dose is 1 mg by mouth 2 to 3 times a day. If needed, your provider will adjust your dose slowly over time. The typical recommended dose ranges from 6 mg to 15 mg daily total, divided into smaller doses and taken throughout the day. The maximum recommended dose is 20 mg daily total.
More on Prazosin (Minipress) dosage
Interactions between Prazosin (Minipress) and other drugs
Prazosin (Minipress) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Prazosin (Minipress). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acebutolol
- Alprenolol
- Atenolol
- Betaxolol
- Bevantolol
- Bisoprolol
- Bucindolol
- Carteolol
- Carvedilol
- Celiprolol
- Dilevalol
- Esmolol
- Labetalol
- Levobunolol
- Mepindolol
- Metipranolol
- Metoprolol
- Nadolol
- Nebivolol
- Oxprenolol
- Penbutolol
- Pindolol
- Propranolol
- Sildenafil
- Sotalol
- Talinolol
- Tertatolol
- Timolol
- Vardenafil
How much does Prazosin (Minipress) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
What are alternatives to Prazosin (Minipress)?
There are a number of medications that your doctor can prescribe in place of Prazosin (Minipress). Compare a few possible alternatives below.
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