Key takeaways
Felodipine ER (Plendil) and nicardipine (Cardene) are both calcium channel blockers used to treat high blood pressure, but they have some differences. Felodipine ER is taken once daily by mouth and is primarily used for high blood pressure. It is available only in tablet form and has a generic version. Nicardipine, on the other hand, can be taken by mouth in capsule form three times daily or administered as an intravenous (IV) drip by a healthcare professional. Besides high blood pressure, nicardipine is also used to treat chest pain (stable angina). Nicardipine can affect your heart rate, potentially causing it to rise, while felodipine ER can also sometimes have this effect. Both medications can cause swelling, headache, and dizziness, and can also cause less-common side effects like chest pain and a racing heart. Felodipine ER is not recommended for people with heart failure, whereas nicardipine should be used cautiously in people with heart problems and those taking beta blockers.
