Key takeaways
Zestoretic (lisinopril/hydrochlorothiazide) and prazosin (Minipress) are both used to lower high blood pressure, but they have some key differences. Zestoretic is a combination of an ACE inhibitor and a diuretic, taken once daily, and is considered a first-choice option for blood pressure management. It works by relaxing blood vessels and removing extra water and electrolytes from your body. On the other hand, prazosin is an alpha blocker that relaxes blood vessels and is typically taken 2 to 3 times a day. Prazosin is not a first-choice medication for high blood pressure due to its side effects like dizziness, headache, and drowsiness. Zestoretic can cause a dry cough and is not safe for pregnant or breastfeeding women, while prazosin can cause drowsiness and is sometimes used off-label for PTSD-related nightmares. Both medications can cause dizziness, but prazosin has a higher risk of causing fainting, especially in older adults.
