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Compare Zestoretic vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lisinopril/hydrochlorothiazide (Zestoretic) and hydrochlorothiazide (Microzide) are both medications used to treat high blood pressure. They both contain hydrochlorothiazide, a diuretic that works by helping you get rid of water and electrolytes from your body. However, Zestoretic is a combination medication that also includes lisinopril, an ACE inhibitor that relaxes blood vessels, while Microzide contains only hydrochlorothiazide. Zestoretic is taken once daily, while Microzide can be taken once or twice daily, depending on your condition. Both medications can cause dizziness and increased urination, but the lisinopril in Zestoretic may also cause a dry cough. Zestoretic is not recommended during pregnancy. Both medications can interact with other drugs, so be sure your prescriber and pharmacist have a complete list of your medications.

  • Zestoretic (lisinopril / hydrochlorothiazide)
    Hydrochlorothiazide
  • Zestoretic (lisinopril / hydrochlorothiazide)
    Hydrochlorothiazide

  • Summary of Zestoretic vs. Hydrochlorothiazide

    Summary for ACE inhibitor/Diuretic (water pill) combo
    Prescription only

    Zestoretic is a combination blood pressure medication for adults. It contains lisinopril (an angiotensin-converting enzyme (ACE) inhibitor) and hydrochlorothiazide (a thiazide diuretic). It comes as a tablet that's taken by mouth once per day. Your prescriber will determine your dosage based on how high your blood pressure is and if you're taking other blood pressure medications. Some of the more common side effects it can cause include dizziness, headache, and cough. Zestoretic (lisinopril / hydrochlorothiazide) is available as a generic.

    Summary for Diuretic (water pill)
    Prescription only

    Hydrochlorothiazide is a diuretic or water pill. It helps lower blood pressure. It also helps with swelling from fluid buildup (edema) caused by some health conditions, like heart failure and kidney problems. People of all ages can take hydrochlorothiazide tablets and capsules. But children typically take much smaller, weight-based doses. You typically take your dose by mouth once (sometimes twice) daily, but avoid nighttime dosing so you won't wake up to urinate. Some common side effects are dizziness and urinating more often.

  • Indications of Zestoretic vs. Hydrochlorothiazide

    Indications for
    •High blood pressure in adults
    Indications for
    •High blood pressure
    •Swelling in the body from fluid buildup (edema)

  • Pros and Cons of Zestoretic vs. Hydrochlorothiazide

    Pros and Const for ACE inhibitor/Diuretic (water pill) combo
    Pros
    •Combines two medications in one pill
    •Taken by mouth
    •Taken once daily
    Cons
    •Can make you urinate more often
    •Might not be appropriate for someone with a sulfa allergy
    •Shouldn't take during pregnancy or breastfeeding
    Pros and Const for Diuretic (water pill)
    Pros
    •Helps getting rid of extra fluid in your body
    •A first-choice treatment option if you have high blood pressure or heart failure
    •Dose can be adjusted based on how well it's working for you
    Cons
    •Can make you urinate more often
    •Can cause electrolytes and fluid levels to be out of balance, which can be dangerous
    •Might not be a good option for people with a sulfa allergy

  • Common Side Effects of Zestoretic vs. Hydrochlorothiazide

    Common Side Effects for
    •Dizziness (8%)
    •Headache (5%)
    •Cough (4%)
    •Extreme tiredness (4%)
    •Feeling lightheaded when standing after sitting or lying down (3%)
    Common Side Effects for
    •Dizziness
    •Weakness
    •Headache
    •Blurry vision
    •Low blood pressure
    •Change in electrolyte levels

  • Warnings of Zestoretic vs. Hydrochlorothiazide

    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Kidney damage
    •Changes in electrolyte, blood sugar, and cholesterol levels
    •Vision problems
    •Lupus
    Common Side Effects for
    •Low fluid and electrolyte levels in the body
    •Possibly higher calcium levels
    •Higher blood sugar
    •Risk of gout
    •Risk of vision problems and glaucoma
    •Use with caution in people with kidney problems

  • Prices with our coupons for Zestoretic vs. Hydrochlorothiazide

    Learn more about Zestoretic
    Learn more about Hydrochlorothiazide

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