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Compare Zestoretic vs. Hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Zestoretic (lisinopril / hydrochlorothiazide)
    Hydrochlorothiazide
  • Zestoretic (lisinopril / hydrochlorothiazide)
    Hydrochlorothiazide

  • Summary of Zestoretic vs. Hydrochlorothiazide

    Summary for ACE inhibitor/Diuretic (water pill) combo
    Prescription only

    Zestoretic is a combination blood pressure medication for adults. It contains lisinopril (an angiotensin-converting enzyme (ACE) inhibitor) and hydrochlorothiazide (a thiazide diuretic). It comes as a tablet that's taken by mouth once per day. Your prescriber will determine your dosage based on how high your blood pressure is and if you're taking other blood pressure medications. Some of the more common side effects it can cause include dizziness, headache, and cough. Zestoretic (lisinopril / hydrochlorothiazide) is available as a generic.

    Summary for Diuretic (water pill)
    Prescription only

    Hydrochlorothiazide is a water pill that helps to lower blood pressure and ease swelling from fluid (edema) caused by many health conditions, such as heart failure and kidney problems. Typically, you take hydrochlorothiazide by mouth once (sometimes twice) daily. Some common side effects of hydrochlorothiazide include dizziness and urinating more often.

  • Indications of Zestoretic vs. Hydrochlorothiazide

    Indications for
    •High blood pressure in adults
    Indications for
    •High blood pressure
    •Swelling in the body from fluids (edema), in addition to other medications

  • Pros and Cons of Zestoretic vs. Hydrochlorothiazide

    Pros and Const for ACE inhibitor/Diuretic (water pill) combo
    Pros
    •Combines two medications in one pill
    •Taken by mouth
    •Taken once daily
    Cons
    •Can make you urinate more often
    •Might not be appropriate for someone with a sulfa allergy
    •Shouldn't take during pregnancy or breastfeeding
    Pros and Const for Diuretic (water pill)
    Pros
    •Does a good job getting rid of extra fluids in your body
    •A first choice treatment option if you have high blood pressure and heart failure
    •Provider can adjust dose based on your response
    •Might protect against osteoporosis over time since it raises the body's level of calcium
    Cons
    •Makes you urinate more often
    •Must be used with caution in people with severe kidney or liver problems
    •Raises risk of gout attacks in people with poor kidney function or a history of gout
    •Can cause electrolytes and fluid levels to be out of balance, which can be dangerous

  • Common Side Effects of Zestoretic vs. Hydrochlorothiazide

    Common Side Effects for
    •Dizziness (8%)
    •Headache (5%)
    •Cough (4%)
    •Extreme tiredness (4%)
    •Feeling lightheaded when standing after sitting or lying down (3%)
    Common Side Effects for
    •Dizziness
    •Weakness
    •Skin more sensitive to sunlight
    •Temporary blurred vision
    •Headache
    •Low blood pressure
    •Electrolytes out of balance
    •Difficulty getting or maintaining an erection

  • Warnings of Zestoretic vs. Hydrochlorothiazide

    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Kidney damage
    •Changes in electrolyte, blood sugar, and cholesterol levels
    •Vision problems
    •Lupus
    Common Side Effects for
    •Vision problems
    •Fluid and electrolyte imbalance
    •Waste build up in body
    •Higher blood sugars
    •Gout
    •Allergic reaction

  • Prices with our coupons for Zestoretic vs. Hydrochlorothiazide

    Learn more about Zestoretic
    Learn more about Hydrochlorothiazide

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