Key takeaways
Felodipine ER (Plendil) and clonidine (Catapres) are both medications used to treat high blood pressure, but they work in different ways and have distinct characteristics. Felodipine ER is a calcium channel blocker that relaxes blood vessels to lower blood pressure and is typically taken once daily in tablet form. In contrast, clonidine is an alpha agonist that works in the brain to reduce stress hormones, slowing down the heart rate and relaxing blood vessels. Clonidine is available in multiple forms, including immediate-release tablets, extended-release tablets, and a topical patch. Felodipine ER can be a first-choice option for treating high blood pressure, while clonidine is usually not, due to the risk of "rebound hypertension" if stopped suddenly. Additionally, clonidine is not recommended for older adults because it can increase the risk of falls. Common side effects of felodipine ER include swelling, headache, and flushing, whereas clonidine commonly causes dry mouth, drowsiness, and dizziness. Both medications require careful monitoring and should not be stopped abruptly without consulting your prescriber.
