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Compare Lopressor vs. Ziac

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Metoprolol tartrate (Lopressor) and Ziac (bisoprolol/hydrochlorothiazide) are both medications used to manage high blood pressure, but they have some key differences. Metoprolol tartrate is a selective beta blocker that is also used to treat chest pain (angina) and to lower the risk of death after a heart attack. It is typically taken twice daily with food. On the other hand, Ziac is a combination of a beta blocker (bisoprolol) and a diuretic (hydrochlorothiazide), which makes you urinate more to help lower blood pressure. Ziac is usually taken once daily and can be taken with or without food. While both medications can cause dizziness and tiredness, Ziac may also make you urinate more often and can cause your skin to be more sensitive to the sun. Additionally, Ziac is not recommended for people with certain breathing problems, whereas metoprolol tartrate is less likely to cause breathing issues compared to other beta blockers. Both medications are available in generic forms, making them more affordable options.

  • Metoprolol tartrate (Lopressor)
    Ziac (bisoprolol / hydrochlorothiazide)
  • Metoprolol tartrate (Lopressor)
    Ziac (bisoprolol / hydrochlorothiazide)

  • Summary of Lopressor vs. Ziac

    Summary for Beta blocker
    Prescription only

    Metoprolol tartrate (Lopressor) is used to treat chest pain and high blood pressure. It's also used to lower the risk of death after a heart attack. This medication is taken by mouth, typically twice daily, though your dosage depends on what condition you have. Some side effects of metoprolol tartrate (Lopressor) include dizziness or tiredness. Metoprolol tartrate (Lopressor) is available as a brand name and generic tablet.

    Summary for Beta blocker / Diuretic (water pill)
    Prescription only

    Ziac, the brand name for bisoprolol/hydrochlorothiazide or bisoprolol/HCTZ, is a combination medication. It's used to treat high blood pressure in adults. It contains two classes of medications: a beta blocker (bisoprolol) and a diuretic (hydrochlorothiazide). It comes as a tablet that's taken by mouth once a day. Some side effects include dizziness and tiredness.

  • Indications of Lopressor vs. Ziac

    Indications for
    •High blood pressure
    •Chest pain (angina)
    •Lower risk of death after heart attack
    Indications for
    •High blood pressure

  • Pros and Cons of Lopressor vs. Ziac

    Pros and Const for Beta blocker
    Pros
    •First choice treatment to prevent chest pain (angina)
    •First choice treatment for people who've had a heart attack because it lowers the risk of death
    •A possible option for mothers who are breastfeeding
    •Less likely to cause breathing problems than with other beta blockers
    •Available as a lower-cost generic version
    Cons
    •Need to take with food
    •Need to take more than once a day
    •Not a first-choice treatment for high blood pressure, unless you have heart failure or heart disease
    •Can hide symptoms of low blood sugar
    •Stopping too suddenly can raise the risk of heart attack and stroke
    Pros and Const for Beta blocker / Diuretic (water pill)
    Pros
    •Only taken once daily
    •Combines two blood pressure medications into one tablet
    •Can take with or without food
    Cons
    •Comes in fixed dosage strengths, so it's harder to adjust the doses of the individual ingredients
    •Can make you urinate more often
    •Not a good option for people with a sulfa allergy

  • Common Side Effects of Lopressor vs. Ziac

    Common Side Effects for
    •Tiredness (10%)
    •Dizziness (10%)
    •Diarrhea (5%)
    •Rash (5%)
    •Depression (5%)
    Common Side Effects for
    •Dizziness (5%)
    •Tiredness (5%)
    •Headache (5%)
    •Diarrhea (4%)

  • Warnings of Lopressor vs. Ziac

    Common Side Effects for
    •Worsening chest pain and heart attacks
    •Heart failure
    •Slow heart rate
    •Hiding symptoms of low blood sugar
    •Hiding symptoms of overactive thyroid
    •Greater risk during surgery
    •Risk of difficulty breathing
    Common Side Effects for
    •Risk of heart problems after stopping Ziac (bisoprolol / hydrochlorothiazide) suddenly
    •Risk of heart failure
    •Changes in fluids and electrolytes in the body
    •Hidden symptoms of low blood sugar
    •Hidden symptoms of overactive thyroid
    •Caution use in people with breathing problems
    •Caution use in people with peripheral artery disease (PAD)
    •Risk of vision problems and glaucoma

  • Prices with our coupons for Lopressor vs. Ziac

    Learn more about Metoprolol tartrate
    Learn more about Ziac

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