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Compare Hyzaar vs. Lopressor HCT

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Hyzaar (losartan/hydrochlorothiazide) and metoprolol/hydrochlorothiazide (Lopressor HCT) are both combination medications used to lower blood pressure, but they work in different ways. Hyzaar combines an angiotensin II receptor blocker (losartan) with a thiazide diuretic (hydrochlorothiazide), while metoprolol/hydrochlorothiazide combines a beta blocker (metoprolol tartrate) with the same thiazide diuretic. Hyzaar is typically taken once daily, whereas metoprolol/hydrochlorothiazide can be taken once or twice daily with food. Hyzaar is not recommended for use during pregnancy due to risks to the unborn baby, while metoprolol/hydrochlorothiazide should be used cautiously in people with certain heart conditions and breathing problems. Both medications can cause dizziness and increased urination, but metoprolol/hydrochlorothiazide also has a risk of masking symptoms of low blood sugar and overactive thyroid. Additionally, Hyzaar is available in generic form, while the brand name for metoprolol/hydrochlorothiazide, Lopressor HCT, is no longer available.

  • Hyzaar (losartan / hydrochlorothiazide)
    Metoprolol/hydrochlorothiazide
  • Hyzaar (losartan / hydrochlorothiazide)
    Metoprolol/hydrochlorothiazide

  • Summary of Hyzaar vs. Lopressor HCT

    Summary for ARB / Diuretic (water pill) combo
    Prescription only

    Hyzaar (losartan / hydrochlorothiazide) is a combination medication that contains two first-choice options for lowering blood pressure. This medication is taken by mouth once daily. Like other blood pressure medications, Hyzaar (losartan / hydrochlorothiazide) can cause you to feel dizzy, especially when you first start this medication or when your provider raises your dose.

    Summary for Beta blocker / Thiazide diuretic
    Prescription only

    Metoprolol/hydrochlorothiazide is a combination medication that's used to lower blood pressure in adults. It contains a beta blocker (metoprolol tartrate) that slows down the heart and a thiazide diuretic (hydrochlorothiazide) that removes extra fluids through your kidneys. Metoprolol/hydrochlorothiazide is taken by mouth, typically once or twice daily with food. Some of the more common side effects of this medication include dizziness and tiredness. The brand name, Lopressor HCT, is no longer available.

  • Indications of Hyzaar vs. Lopressor HCT

    Indications for
    •High blood pressure
    •Lower the risk of stroke in people with high blood pressure and an enlarged left ventricle of the heart
    Indications for
    •High blood pressure

  • Pros and Cons of Hyzaar vs. Lopressor HCT

    Pros and Const for ARB / Diuretic (water pill) combo
    Pros
    •Contains two first-choice blood pressure medications
    •Convenient to take a combination of two medications in one pill taken just once a day
    •Protects your kidneys, which is especially useful for people with diabetes or mild-to-moderate kidney disease
    •Taken by mouth once per day
    Cons
    •Can make you urinate more often
    •Must be avoided in pregnant females
    •More difficult to customize the dose since Hyzaar (losartan / hydrochlorothiazide) is a combination of two medications
    •Only available as a tablet
    Pros and Const for Beta blocker / Thiazide diuretic
    Pros
    •Taken by mouth just once or twice daily
    •Lowers risk of heart attack and stroke
    •Combines 2 medications into 1 pill for convenience
    Cons
    •Can make you urinate more often
    •Stopping suddenly can raise risk of chest pain and heart attack
    •Fixed dosing, so not as easy to adjust the dose (compared to taking each medication separately)

  • Common Side Effects of Hyzaar vs. Lopressor HCT

    Common Side Effects for
    •Upper respiratory tract infection (i.e., common cold; 6%)
    •Dizziness (6%)
    •Back pain (2%)
    Common Side Effects for
    •Tiredness
    •Dizziness
    •Weakness
    •Sun sensitivity

    Note: Side effects listed are from people who took metoprolol tartrate or hydrochlorothiazide in clinical studies.

  • Warnings of Hyzaar vs. Lopressor HCT

    Common Side Effects for
    •Not for use during pregnancy
    •Low blood pressure
    •Kidney damage
    •Changes in electrolyte, blood sugar, and cholesterol levels
    •Vision problems
    •Lupus
    Common Side Effects for
    •Risk of chest pain and heart attack
    •Heart failure
    •Risk of difficulty breathing
    •Slow heart rate
    •Greater risk during surgery
    •Hiding symptoms of low blood sugar
    •Hiding symptoms of overactive thyroid
    •Fluid, electrolyte, and kidney problems
    •Eye problems
    •Lupus
    •Serious allergic reactions

  • Prices with our coupons for Hyzaar vs. Lopressor HCT

    Learn more about Hyzaar
    Learn more about Metoprolol/hydrochlorothiazide

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