provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Metoprolol / HCTZ Coupon - Metoprolol / HCTZ 50mg/25mg tablet

metoprolol / HCTZ

Generic Lopressor HCT
Used for Hypertension
Used for Hypertension

Metoprolol/hydrochlorothiazide is a combination medication that's used to lower blood pressure in adults. It contains a beta blocker (metoprolol tartrate) that slows down the heart and a thiazide diuretic (hydrochlorothiazide) that removes extra fluids through your kidneys. Metoprolol/hydrochlorothiazide is taken by mouth, typically once or twice daily with food. Some of the more common side effects of this medication include dizziness and tiredness. The brand name, Lopressor HCT, is no longer available.

Last reviewed on January 31, 2024
basics-icon

What is Metoprolol/hydrochlorothiazide?

What is Metoprolol/hydrochlorothiazide used for?

How Metoprolol/hydrochlorothiazide works

Metoprolol/hydrochlorothiazide is a combination medication:

Are you looking for information on metoprolol alone or hydrochlorothiazide alone instead?

Drug Facts

Common BrandsLopressor HCT (brand name no longer available)
Drug ClassBeta blocker / Thiazide diuretic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$124.87(save 83.62%)
GoodRx discount
$20.45
See prices
basics-icon

What are the side effects of Metoprolol/hydrochlorothiazide?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Tiredness
  • Dizziness
  • Weakness
  • Sun sensitivity
Note: Side effects listed are from people who took metoprolol tartrate or hydrochlorothiazide in clinical studies.

Other Side Effects

  • Nausea or vomiting
  • Headache
  • Rash and itching
  • Diarrhea
  • Depression

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Heart failure: trouble breathing, fast weight gain, feeling very tired, chest pain, swelling in the legs, ankles, or feet
  • Bronchospasm: tightness in the chest, trouble catching your breath, difficulty breathing, wheezing, cough, dizziness, extreme tiredness
  • Serious kidney problems: tiredness, nausea, vomiting, swelling, feeling confused, changes in how much or how often you urinate

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain or discomfort

decreased urine

dry mouth

increased thirst

lightheadedness, dizziness, or fainting

loss of appetite

mood changes

muscle pain or cramps

nausea or vomiting

numbness or tingling in the hands, feet, or lips

seizures

slow or irregular heartbeat

unusual tiredness or weakness

Less common

Ankle, knee, or great toe joint pain

decreased ability to exercise

difficult or labored breathing

joint stiffness or swelling

lower back or side pain

swelling of the face, fingers, feet, or lower legs

tightness in the chest

Incidence not known

Persistent non-healing sore

pink growth

reddish patch or irritated area

shiny bump

white, yellow or waxy scar-like area

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chemical imbalance in the blood

cold, clammy skin

coma

confusion

cough

dilated neck veins

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

fast or pounding heartbeat or pulse

frequent urination

headache

increased volume of pale, dilute urine

irregular breathing

irritability

noisy breathing

not able to pass urine

pain or aching in the lower legs

pain or weakness in the hands or feet

seizures

sweating

trembling

unconsciousness

very drowsy or sleepy

weak pulse

weakness and heaviness of the legs

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Chills

diarrhea

feeling of constant movement of self or surroundings

fever

general feeling of discomfort or illness

muscle aches

nightmares

runny nose

sensation of spinning

shivering

sleepiness

sore throat

trouble sleeping

unusual drowsiness, dullness, or feeling of sluggishness

Less common

Continuing ringing or buzzing or other unexplained noise in the ears

decreased interest in sexual intercourse

difficulty having a bowel movement (stool)

earache

hearing loss

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

pinpoint red or purple spots on the skin

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Metoprolol/hydrochlorothiazide

thumbs-up

Pros

Taken by mouth just once or twice daily

Lowers risk of heart attack and stroke

Combines 2 medications into 1 pill for convenience

thumbs-down

Cons

Can make you urinate more often

Stopping suddenly can raise risk of chest pain and heart attack

Fixed dosing, so not as easy to adjust the dose (compared to taking each medication separately)

pharmacist-tips

Pharmacist tips for Metoprolol/hydrochlorothiazide

pharmacist
  • It's best to take metoprolol/hydrochlorothiazide with food because food helps your body better absorb this medication.

    • If you're taking metoprolol/hydrochlorothiazide for the first time, it might take some time for you to experience the most benefit from this medication. Your provider will ask you to check and record your blood pressure often to get an idea of how this medication is working for you. They might need to adjust your dose of metoprolol/hydrochlorothiazide based on your blood pressure numbers.

      • Don't stop taking metoprolol/hydrochlorothiazide suddenly since it can trigger heart problems, such as chest pain or heart attack. If you want to stop taking this medication, let your provider know. They can help you stop safely by lowering your dose slowly over time.

        • If you miss a dose of metoprolol/hydrochlorothiazide, just skip the missed dose. Then, take your next dose at the next scheduled time. Don't take 2 doses to make up the missed dose.

          • Metoprolol/hydrochlorothiazide can make you urinate more often, so don't take it too close to bedtime. If you're taking this medication once daily, consider taking it in the morning. And if you're taking metoprolol/hydrochlorothiazide twice daily, you can take it in the morning and afternoon.

            • Taking metoprolol/hydrochlorothiazide can make you feel dizzy, especially when you first start this medication and any time your provider raises your dose. But this side effect should get better as your body gets used to metoprolol/hydrochlorothiazide.

              • To prevent dizziness and falls while taking metoprolol/hydrochlorothiazide, get up slowly if you've been sitting or lying down. Hold on to something stable as you pull yourself up.

                • Because metoprolol/hydrochlorothiazide lowers your heart rate, it can make it harder for you to identify symptoms of low blood sugar, such as fast heart beats. This is especially important for people with diabetes since you might not be able to rely on all the typical symptoms of low blood sugar to warn you of a dangerous drop in your sugar levels. Sweating might be the only symptom not affected.

                  faqs

                  Frequently asked questions about Metoprolol/hydrochlorothiazide

                  Can I take metoprolol and hydrochlorothiazide together?
                  Yes, providers sometimes prescribe metoprolol and hydrochlorothiazide together because they help lower blood pressure in different ways. Metoprolol slows down heart rate, so it's easier for your heart to pump blood throughout the body. Hydrochlorothiazide, on the other hand, lowers blood pressure by getting rid of extra fluids in the body through the kidneys. Metoprolol/hydrochlorothiazide is a combination option for people who need to take both medications at the same time.
                  Are metoprolol and hydrochlorothiazide the same thing?
                  No, metoprolol and hydrochlorothiazide aren't the same. While they both lower blood pressure, they do so in different ways. Metoprolol is a cardioselective beta blocker that slows heart rate so that your heart has an easier time pumping blood to the rest of the body. Hydrochlorothiazide is a thiazide diuretic that removes the extra fluids in the body through the urine.
                  Does metoprolol/hydrochlorothiazide contain a diuretic?
                  Yes, hydrochlorothiazide is a thiazide diuretic, also known as a water pill. Because it lowers blood pressure by helping you get rid of extra fluids through the urine, you'll likely need to use the bathroom more often after starting metoprolol/hydrochlorothiazide. Your provider might recommend that you take this medication earlier in the day, such as morning or afternoon, so that you won't need to use the bathroom often at night.
                  Can you take metoprolol/hydrochlorothiazide and amlodipine (Norvasc) together?
                  If you're having a hard time keeping your blood pressure under control with just metoprolol/hydrochlorothiazide, your provider might add on amlodipine (Norvasc). This medication is a calcium channel blocker, so it works differently than metoprolol/hydrochlorothiazide. It lowers blood pressure by relaxing your arteries and making it easier for your heart to pump blood. Your provider will work with you closely to find the best treatment to lower your blood pressure to a safe level.
                  Can I drink alcohol while taking metoprolol/hydrochlorothiazide?
                  It's best to avoid drinking alcohol when you're taking metoprolol/hydrochlorothiazide. Doing so can raise your risk of side effects, such as dizziness and fainting. If you drink alcohol regularly and it's difficult for you to stop, ask your provider what might be a safer amount to drink. They can also point you to resources to help you quit drinking.
                  GoodRxEducationalIcon

                  How to save using GoodRx

                  Compare Prices
                  1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
                  Select your free coupon
                  2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
                  Show coupon to your pharmacist
                  3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
                  Get free couponLearn more
                  warings-icon

                  What are the risks and warnings for Metoprolol/hydrochlorothiazide?

                  Metoprolol/hydrochlorothiazide can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Risk of chest pain and heart attack

                  • Risk factors: Suddenly stopping metoprolol/hydrochlorothiazide

                    Don't suddenly stop taking metoprolol/hydrochlorothiazide without first speaking to your provider. Doing so can cause or worsen chest pain or heart attack. If you've been taking this medication for a while and want to stop, your provider will lower your dose slowly over the course of 1-2 weeks.

                    risk-warning

                    Heart failure

                    • Risk factors: Heart failure

                      People with heart failure shouldn't take metoprolol/hydrochlorothiazide if their heart failure symptoms aren’t well-managed. That’s because this medication can make your condition worse, especially if your provider raises your dose. But you might be able to take metoprolol/hydrochlorothiazide if your healthcare provider thinks your symptoms are under control. Let your healthcare provider know right away if you experience symptoms of heart failure, such as fluid build-up in different areas of the body including the ankles, legs, and lungs, and difficulty breathing.

                      risk-warning

                      Risk of difficulty breathing

                      • Risk factors: Chronic obstructive pulmonary disease (COPD) | Asthma

                        Metoprolol/hydrochlorothiazide can cause the vessels in your lung to tighten. This can make breathing difficult, especially in people with breathing problems, like asthma or COPD. Metoprolol/hydrochlorothiazide might also cause certain medications taken to ease these conditions to not work as well. Let your doctor know if you have any breathing problems before starting metoprolol/hydrochlorothiazide.

                        risk-warning

                        Slow heart rate

                        • Risk factors: Taking other medications that slow heart rate | Heart rhythm problems

                          People who've taken metoprolol/hydrochlorothiazide have experienced their heart rate dropping too low. If you have heart problems, such as heart block, let your provider know. They might ask you to check your heart rate regularly after starting this medication. If your heart rate drops below 60 beats per minute or if you feel symptoms such as dizziness, chest pain, or trouble catching your breath, let your provider know. They might taper you off of metoprolol/hydrochlorothiazide slowly and prescribe a different medication for your blood pressure.

                          risk-warning

                          Greater risk during surgery

                          • Risk factors: Major surgery requiring anesthesia

                            Both beta-blockers, like metoprolol, and medications used for anesthesia can lower your heart rate. So, if you’re planning to undergo a major surgery that requires anesthesia, tell your surgeon that you’re on metoprolol/hydrochlorothiazide so that they can monitor your heart closely.

                            risk-warning

                            Hiding symptoms of low blood sugar

                            • Risk factors: Diabetes

                              Taking metoprolol/hydrochlorothiazide can make it difficult for you to identify symptoms of low blood sugar, such as fast heart beat or tremors. If you’re taking medications, like glipizide or insulin, to lower your blood sugar, you might not be able to rely on all the typical symptoms of low blood sugar (e.g., irritability, sight tremors, confusion, and fast heartbeat) to warn you of a dangerous drop in your sugar levels. Sweating might be the only symptom not affected by taking metoprolol/hydrochlorothiazide. Speak with your healthcare provider about when and how to monitor your blood sugar if you start metoprolol/hydrochlorothiazide.

                              risk-warning

                              Hiding symptoms of overactive thyroid

                              • Risk factors: Hyperthyroidism

                                If you have hyperthyroidism (overactive thyroid), talk to your healthcare provider before stopping metoprolol/hydrochlorothiazide. Because metoprolol/hydrochlorothiazide lowers your heart rate, it may be harder to notice heart-related symptoms that are caused by hyperthyroidism. In some people, stopping this medication suddenly may lead to a condition called a "thyroid storm,” which may include symptoms such as a high temperature, rapid heartbeat, and fainting.

                                risk-warning

                                Fluid, electrolyte, and kidney problems

                                • Risk factors: Kidney problems | Not enough fluid in your body | Taking other medications that can cause kidney damage

                                  Taking metoprolol/hydrochlorothiazide can cause your fluids and electrolyte levels to be out of balance. This can put you at risk for conditions such as low potassium and low sodium levels. Your provider might order blood work to check your electrolyte level periodically during treatment. Let your provider know if you experience symptoms such as dizziness or tiredness.

                                  In addition, taking metoprolol/hydrochlorothiazide can cause serious kidney problems for people who've already have kidney problems, heart failure, or are dehydrated. If you develop kidney problems, or if your kidney problems worsen while taking metoprolol/hydrochlorothiazide, your provider might recommend that you stop taking this medication. Let your provider know if you're urinating less often than usual, as this could be a sign that your kidneys aren't working as well.

                                  risk-warning

                                  Eye problems

                                  • Risk factors: Sulfonamide or penicillin allergy

                                    Though rare, hydrochlorothiazide can cause eye problems, such as vision loss, eye pain, or angle-closure glaucoma. If it happens, symptoms can start within hours or weeks of starting metoprolol/hydrochlorothiazide. If you experience any vision changes, let your provider know because they might ask you to stop this medication. If left untreated, certain conditions (like glaucoma) can lead to permanent vision loss.

                                    risk-warning

                                    Lupus

                                    In some rare cases, metoprolol/hydrochlorothiazide can cause worsening of or new lupus. Let your provider know if you notice a rash across your cheeks and nose or feel very tired.

                                    risk-warning

                                    Serious allergic reactions

                                    • Risk factors: History of sulfa allergies

                                      There is a small risk that people with allergies to sulfa medications can experience similar reactions with metoprolol/hydrochlorothiazide. Get medical attention right away if you develop signs of a serious allergic reaction such as swelling in the throat or difficulty breathing.

                                      dosage

                                      Metoprolol/hydrochlorothiazide dosage forms

                                      The average cost for 90 tablets of 50mg/25mg of Metoprolol/hydrochlorothiazide is $42.13 with a free GoodRx coupon. This is 66.26% off the average retail price of $124.87.
                                      tablet
                                      Tablet
                                      DosageQuantityPrice as low asPrice per unit
                                      50mg/25mg90 tablets$42.13$0.47
                                      100mg/25mg90 tablets$56.56$0.63
                                      100mg/50mg30 tablets$20.45$0.68

                                      Typical dosing for Metoprolol/hydrochlorothiazide

                                      The typical dose is to take 1 tablet of metoprolol/hydrochlorothiazide by mouth once or twice daily, as directed.

                                      Usually, the total daily dose of hydrochlorothiazide ranges from 25 mg to 50 mg. The total daily dose of metoprolol tartrate ranges from 100 mg to 200 mg.

                                      interactions

                                      Interactions between Metoprolol/hydrochlorothiazide and other drugs

                                      Metoprolol/hydrochlorothiazide may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Metoprolol/hydrochlorothiazide. Please note that only the generic name of each medication is listed below.

                                      Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                      Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                      drug-cost

                                      How much does Metoprolol/hydrochlorothiazide cost?

                                      To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                                      Metoprolol/hydrochlorothiazide (generic)
                                      View prices & coupons
                                      contraindications-icon

                                      Metoprolol/hydrochlorothiazide contraindications

                                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Metoprolol/hydrochlorothiazide will not be safe for you to take.
                                      • Cardiogenic shock

                                      • Worsening heart failure with symptoms not under control

                                      • Heart block, heart rate slower than 60 beats per minute, heart rhythm problem (sick sinus syndrome)

                                      • Not making urine

                                      • Sulfa allergy

                                      alternatives

                                      What are alternatives to Metoprolol/hydrochlorothiazide?

                                      There are a number of medications that your doctor can prescribe in place of Metoprolol/hydrochlorothiazide. Compare a few possible alternatives below.
                                      Metoprolol/hydrochlorothiazide
                                      $20.45 Lowest GoodRx priceView Prices
                                      Used for:
                                      • High blood pressure

                                      $17.61 Lowest GoodRx priceView Prices
                                      images

                                      Metoprolol/hydrochlorothiazide images

                                      Peach Round M 424 - Metoprolol Tartrate / Hydrochlorothiazide 50mg-25mg Tablet
                                      This medicine is Peach, Round, Scored Tablet Imprinted With "M 424".Peach Round M 424 - Metoprolol Tartrate / Hydrochlorothiazide 50mg-25mg Tablet
                                      White Round L 230 - Metoprolol Tartrate / Hydrochlorothiazide 50mg-25mg Tablet
                                      This medicine is White, Round, Scored Tablet Imprinted With "L 230".White Round L 230 - Metoprolol Tartrate / Hydrochlorothiazide 50mg-25mg Tablet
                                      Yellow Oblong S 370 - Metoprolol Tartrate / Hydrochlorothiazide 50mg-25mg Tablet
                                      This medicine is Yellow, Oblong, Scored Tablet Imprinted With "S 370".Yellow Oblong S 370 - Metoprolol Tartrate / Hydrochlorothiazide 50mg-25mg Tablet

                                      Get savings updates for Metoprolol/hydrochlorothiazide

                                      Receive price alerts, news, and other messages from GoodRx about Metoprolol/hydrochlorothiazide and other healthcare topics and relevant savings offers.

                                      By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                                      References

                                      Best studies we found

                                      Alembic Pharmaceuticals Inc. (2024). Metoprolol tartrate- metoprolol tablet [package insert]. DailyMed.

                                      National Heart, Lung, and Blood Institute. (2022). What is cardiogenic shock?

                                      Sun Pharmaceutical Industries, Inc. (2024). Metoprolol tartrate and hydrochlorothiazide tablet [package insert]. DailyMed.

                                      View All References (2)

                                      Vue, M. H., et al. (2011). Drug-induced glucose alterations part 1: Drug-induced hypoglycemia. Diabetes Spectrum.

                                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                                      Was this page helpful?

                                      Browse medications

                                      View All

                                      Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.