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Metoprolol/HCTZ

Metoprolol/HCTZ Side Effects

Connie Zheng, PharmDAllison Gourley, PharmD
Reviewed by Connie Zheng, PharmD, Allison Gourley, PharmD
Last reviewed on February 1, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Tiredness
  • Dizziness
  • Weakness
  • Sun sensitivity

Note: Side effects listed are from people who took metoprolol tartrate or hydrochlorothiazide in clinical studies.

Less Common Side Effects

  • Nausea or vomiting
  • Headache
  • Rash and itching
  • Diarrhea
  • Depression

Metoprolol/HCTZ serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Heart failure: trouble breathing, fast weight gain, feeling very tired, chest pain, swelling in the legs, ankles, or feet
  • Bronchospasm: tightness in the chest, trouble catching your breath, difficulty breathing, wheezing, cough, dizziness, extreme tiredness
  • Serious kidney problems: tiredness, nausea, vomiting, swelling, feeling confused, changes in how much or how often you urinate

Source: DailyMed

The following Metoprolol/HCTZ side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain or discomfort

decreased urine

dry mouth

increased thirst

lightheadedness, dizziness, or fainting

loss of appetite

mood changes

muscle pain or cramps

nausea or vomiting

numbness or tingling in the hands, feet, or lips

seizures

slow or irregular heartbeat

unusual tiredness or weakness

Less common

Ankle, knee, or great toe joint pain

decreased ability to exercise

difficult or labored breathing

joint stiffness or swelling

lower back or side pain

swelling of the face, fingers, feet, or lower legs

tightness in the chest

Incidence not known

Persistent non-healing sore

pink growth

reddish patch or irritated area

shiny bump

white, yellow or waxy scar-like area

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chemical imbalance in the blood

cold, clammy skin

coma

confusion

cough

dilated neck veins

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

fast or pounding heartbeat or pulse

frequent urination

headache

increased volume of pale, dilute urine

irregular breathing

irritability

noisy breathing

not able to pass urine

pain or aching in the lower legs

pain or weakness in the hands or feet

seizures

sweating

trembling

unconsciousness

very drowsy or sleepy

weak pulse

weakness and heaviness of the legs

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Chills

diarrhea

feeling of constant movement of self or surroundings

fever

general feeling of discomfort or illness

muscle aches

nightmares

runny nose

sensation of spinning

shivering

sleepiness

sore throat

trouble sleeping

unusual drowsiness, dullness, or feeling of sluggishness

Less common

Continuing ringing or buzzing or other unexplained noise in the ears

decreased interest in sexual intercourse

difficulty having a bowel movement (stool)

earache

hearing loss

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

pinpoint red or purple spots on the skin

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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