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Compare Ziac vs. Lopressor HCT

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ziac (bisoprolol/hydrochlorothiazide) and metoprolol/hydrochlorothiazide are both combination beta blocker medications used to treat high blood pressure, but they have some differences. Ziac combines bisoprolol, a cardioselective beta blocker, with hydrochlorothiazide, a thiazide diuretic. Metoprolol/hydrochlorothiazide combines metoprolol tartrate, another selective beta blocker, with the same diuretic. Ziac is typically taken once daily, while metoprolol/hydrochlorothiazide can be taken once or twice daily with food. Both medications can cause dizziness and tiredness, but Ziac may also cause headaches and diarrhea. Additionally, Lopressor HCT, the brand name for metoprolol/hydrochlorothiazide, is no longer available, but both medications are available as low-cost generics. Both medications should not be stopped suddenly due to the risk of serious heart problems.

  • Ziac (bisoprolol / hydrochlorothiazide)
    Metoprolol/hydrochlorothiazide
  • Ziac (bisoprolol / hydrochlorothiazide)
    Metoprolol/hydrochlorothiazide

  • Summary of Ziac vs. Lopressor HCT

    Summary for Beta blocker / Diuretic (water pill)
    Prescription only

    Ziac, the brand name for bisoprolol/hydrochlorothiazide or bisoprolol/HCTZ, is a combination medication. It's used to treat high blood pressure in adults. It contains two classes of medications: a beta blocker (bisoprolol) and a diuretic (hydrochlorothiazide). It comes as a tablet that's taken by mouth once a day. Some side effects include dizziness and tiredness.

    Summary for Beta blocker / Thiazide diuretic
    Prescription only

    Metoprolol/hydrochlorothiazide is a combination medication that's used to lower blood pressure in adults. It contains a beta blocker (metoprolol tartrate) that slows down the heart and a thiazide diuretic (hydrochlorothiazide) that removes extra fluids through your kidneys. Metoprolol/hydrochlorothiazide is taken by mouth, typically once or twice daily with food. Some of the more common side effects of this medication include dizziness and tiredness. The brand name, Lopressor HCT, is no longer available.

  • Indications of Ziac vs. Lopressor HCT

    Indications for
    •High blood pressure
    Indications for
    •High blood pressure

  • Pros and Cons of Ziac vs. Lopressor HCT

    Pros and Const for Beta blocker / Diuretic (water pill)
    Pros
    •Only taken once daily
    •Combines two blood pressure medications into one tablet
    •Can take with or without food
    Cons
    •Comes in fixed dosage strengths, so it's harder to adjust the doses of the individual ingredients
    •Can make you urinate more often
    •Not a good option for people with a sulfa allergy
    Pros and Const for Beta blocker / Thiazide diuretic
    Pros
    •Taken by mouth just once or twice daily
    •Lowers risk of heart attack and stroke
    •Combines 2 medications into 1 pill for convenience
    Cons
    •Can make you urinate more often
    •Stopping suddenly can raise risk of chest pain and heart attack
    •Fixed dosing, so not as easy to adjust the dose (compared to taking each medication separately)

  • Common Side Effects of Ziac vs. Lopressor HCT

    Common Side Effects for
    •Dizziness (5%)
    •Tiredness (5%)
    •Headache (5%)
    •Diarrhea (4%)
    Common Side Effects for
    •Tiredness
    •Dizziness
    •Weakness
    •Sun sensitivity

    Note: Side effects listed are from people who took metoprolol tartrate or hydrochlorothiazide in clinical studies.

  • Warnings of Ziac vs. Lopressor HCT

    Common Side Effects for
    •Risk of heart problems after stopping Ziac (bisoprolol / hydrochlorothiazide) suddenly
    •Risk of heart failure
    •Changes in fluids and electrolytes in the body
    •Hidden symptoms of low blood sugar
    •Hidden symptoms of overactive thyroid
    •Caution use in people with breathing problems
    •Caution use in people with peripheral artery disease (PAD)
    •Risk of vision problems and glaucoma
    Common Side Effects for
    •Risk of chest pain and heart attack
    •Heart failure
    •Risk of difficulty breathing
    •Slow heart rate
    •Greater risk during surgery
    •Hiding symptoms of low blood sugar
    •Hiding symptoms of overactive thyroid
    •Fluid, electrolyte, and kidney problems
    •Eye problems
    •Lupus
    •Serious allergic reactions

  • Prices with our coupons for Ziac vs. Lopressor HCT

    Learn more about Ziac
    Learn more about Metoprolol/hydrochlorothiazide

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