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Compare Hydrochlorothiazide vs. Digoxin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Hydrochlorothiazide (Microzide) and digoxin (Lanoxin) are both prescription medications, but they serve different purposes and belong to different drug classes. Hydrochlorothiazide is a diuretic, also known as a water pill, that helps lower blood pressure and reduce swelling by making you urinate more. In contrast, digoxin is an antiarrhythmic medication used to treat heart failure and atrial fibrillation by helping your heart pump more effectively and controlling heart rate. Hydrochlorothiazide is typically taken once daily and is available as a lower-cost generic. Digoxin, also available as a generic, can be taken once or twice daily, with the dosage depending on factors like age and kidney health. While hydrochlorothiazide can cause side effects like dizziness and increased urination, digoxin has a risk of serious toxicity, which requires regular blood tests to monitor. Both medications interact with many other drugs, so it's important to inform your healthcare provider about all the medications you are taking.

  • Hydrochlorothiazide
    Digoxin (Lanoxin)
  • Hydrochlorothiazide
    Digoxin (Lanoxin)

  • Summary of Hydrochlorothiazide vs. Digoxin

    Summary for Diuretic (water pill)
    Prescription only

    Hydrochlorothiazide is a water pill that helps to lower blood pressure and ease swelling from fluid (edema) caused by many health conditions, such as heart failure and kidney problems. Typically, you take hydrochlorothiazide by mouth once (sometimes twice) daily. Some common side effects of hydrochlorothiazide include dizziness and urinating more often.

    Summary for Antiarrhythmic
    Prescription only

    Digoxin (Lanoxin) is an antiarrhythmic medication used to treat heart failure and atrial fibrillation (AFib) in adults and children. It's taken by mouth typically once or twice daily, but the specific dosage will depend on several things like your age, weight, and blood digoxin levels. Side effects include changes in vision, stomach upset, and dizziness. There's also a risk of digoxin toxicity, which means having too much of the medication in your body. This can lead to severe side effects such as vision changes and changes to the heart rhythm.

  • Indications of Hydrochlorothiazide vs. Digoxin

    Indications for
    •High blood pressure
    •Swelling in the body from fluids (edema), in addition to other medications
    Indications for
    •Heart failure in adults and children ages 5 years and older
    •Atrial fibrillation (AFib) in adults

  • Pros and Cons of Hydrochlorothiazide vs. Digoxin

    Pros and Const for Diuretic (water pill)
    Pros
    •Does a good job getting rid of extra fluids in your body
    •A first choice treatment option if you have high blood pressure and heart failure
    •Provider can adjust dose based on your response
    •Might protect against osteoporosis over time since it raises the body's level of calcium
    Cons
    •Makes you urinate more often
    •Must be used with caution in people with severe kidney or liver problems
    •Raises risk of gout attacks in people with poor kidney function or a history of gout
    •Can cause electrolytes and fluid levels to be out of balance, which can be dangerous
    Pros and Const for Antiarrhythmic
    Pros
    •Can be used in young children to treat heart failure
    •Doesn't affect blood pressure much
    •Available as a lower-cost generic
    Cons
    •Can cause serious and potentially life-threatening side effects if medication levels in the blood are too high
    •Need to get regular blood tests during treatment
    •Interacts with many medications

  • Common Side Effects of Hydrochlorothiazide vs. Digoxin

    Common Side Effects for
    •Dizziness
    •Weakness
    •Skin more sensitive to sunlight
    •Temporary blurred vision
    •Headache
    •Low blood pressure
    •Electrolytes out of balance
    •Difficulty getting or maintaining an erection
    Common Side Effects for
    •Changes in heart rate
    •Nausea
    •Vomiting
    •Diarrhea
    •Reduced appetite

  • Warnings of Hydrochlorothiazide vs. Digoxin

    Common Side Effects for
    •Vision problems
    •Fluid and electrolyte imbalance
    •Waste build up in body
    •Higher blood sugars
    •Gout
    •Allergic reaction
    Common Side Effects for
    •Abnormal heart rhythm
    •Digoxin toxicity
    •Worsening heart conditions
    •Less efficacy in people with low calcium levels
    •Different responses in people with thyroid and metabolism problems

  • Prices with our coupons for Hydrochlorothiazide vs. Digoxin

    Learn more about Hydrochlorothiazide
    Learn more about Digoxin

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