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Hydrochlorothiazide vs. Digoxin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Hydrochlorothiazide (Microzide) and digoxin (Lanoxin) are both prescription medications, but they serve different purposes and belong to different drug classes. Hydrochlorothiazide is a diuretic, also known as a water pill, that helps lower blood pressure and reduce swelling by making you urinate more. In contrast, digoxin is an antiarrhythmic medication used to treat heart failure and atrial fibrillation by helping your heart pump more effectively and controlling heart rate. Hydrochlorothiazide is typically taken once daily and is available as a lower-cost generic. Digoxin, also available as a generic, can be taken once or twice daily, with the dosage depending on factors like age and kidney health. While hydrochlorothiazide can cause side effects like dizziness and increased urination, digoxin has a risk of serious toxicity, which requires regular blood tests to monitor. Both medications interact with many other drugs, so it's important to inform your healthcare provider about all the medications you are taking.

Hydrochlorothiazide

 

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Digoxin

(Lanoxin)

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Summary for Hydrochlorothiazide

Prescription only

Hydrochlorothiazide is a diuretic or water pill. It helps lower blood pressure. It also helps with swelling from fluid buildup (edema) caused by some health conditions, like heart failure and kidney problems. People of all ages can take hydrochlorothiazide tablets and capsules. But children typically take much smaller, weight-based doses. You typically take your dose by mouth once (sometimes twice) daily, but avoid nighttime dosing so you won't wake up to urinate. Some common side effects are dizziness and urinating more often.

Indications for Hydrochlorothiazide

Pros and Cons for Hydrochlorothiazide

Pros

  • Helps getting rid of extra fluid in your body
  • A first-choice treatment option if you have high blood pressure or heart failure
  • Dose can be adjusted based on how well it's working for you

Cons

  • Can make you urinate more often
  • Can cause electrolytes and fluid levels to be out of balance, which can be dangerous
  • Might not be a good option for people with a sulfa allergy

Common Side Effects for Hydrochlorothiazide

  • Dizziness
  • Weakness
  • Headache
  • Blurry vision
  • Low blood pressure
  • Change in electrolyte levels

Warnings for Hydrochlorothiazide

  • Low fluid and electrolyte levels in the body
  • Possibly higher calcium levels
  • Higher blood sugar
  • Risk of gout
  • Risk of vision problems and glaucoma
  • Use with caution in people with kidney problems

Summary for Digoxin

Prescription only

Digoxin (Lanoxin) is an antiarrhythmic medication used to treat heart failure and atrial fibrillation (AFib) in adults and children. It's taken by mouth typically once or twice daily, but the specific dosage will depend on several things like your age, weight, and blood digoxin levels. Side effects include changes in vision, stomach upset, and dizziness. There's also a risk of digoxin toxicity, which means having too much of the medication in your body. This can lead to severe side effects such as vision changes and changes to the heart rhythm.

Indications for Digoxin

Pros and Cons for Digoxin

Pros

  • Can be used in young children to treat heart failure
  • Doesn't affect blood pressure much
  • Available as a lower-cost generic

Cons

  • Can cause serious and potentially life-threatening side effects if medication levels in the blood are too high
  • Need to get regular blood tests during treatment
  • Interacts with many medications

Common Side Effects for Digoxin

  • Changes in heart rate
  • Nausea
  • Vomiting
  • Diarrhea
  • Reduced appetite

Warnings for Digoxin

  • Abnormal heart rhythm
  • Digoxin toxicity
  • Worsening heart conditions
  • Less efficacy in people with low calcium levels
  • Different responses in people with thyroid and metabolism problems

Prices with our coupons for Hydrochlorothiazide vs. Digoxin

Price Card Drug Icon
Hydrochlorothiazide30 tablets / 25mg
$4.00$4.00
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Digoxin90 tablets / 125mcg
$24.00$24.00
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