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Compare Ziac vs. Hyzaar

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ziac (bisoprolol/hydrochlorothiazide) and Hyzaar (losartan/hydrochlorothiazide) are both combination medications used to treat high blood pressure, but they work in different ways. Ziac combines a beta blocker (bisoprolol) and a diuretic (hydrochlorothiazide), while Hyzaar combines an angiotensin II receptor blocker (ARB) (losartan) and a diuretic (hydrochlorothiazide). Ziac is typically not a first-choice medication for high blood pressure, whereas both components of Hyzaar are considered first-choice options. Ziac can cause dizziness and tiredness, and it’s important not to stop it suddenly due to the risk of serious heart problems. Hyzaar can also cause dizziness and may lead to high potassium levels, which can be serious. Both medications are taken once daily and can make you urinate more often. However, Hyzaar is specifically noted for its benefits in protecting the kidneys, especially in people with diabetes or mild-to-moderate kidney disease. Neither medication is recommended during pregnancy due to potential risks to the unborn baby.

drug combination

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  • Ziac (bisoprolol / hydrochlorothiazide)
    Hyzaar (losartan / hydrochlorothiazide)
  • Ziac (bisoprolol / hydrochlorothiazide)
    Hyzaar (losartan / hydrochlorothiazide)

  • Summary of Ziac vs. Hyzaar

    Summary for Beta blocker / Diuretic (water pill)
    Prescription only

    Ziac, the brand name for bisoprolol/hydrochlorothiazide or bisoprolol/HCTZ, is a combination medication. It's used to treat high blood pressure in adults. It contains two classes of medications: a beta blocker (bisoprolol) and a diuretic (hydrochlorothiazide). It comes as a tablet that's taken by mouth once a day. Some side effects include dizziness and tiredness.

    Summary for ARB / Diuretic (water pill) combo
    Prescription only

    Hyzaar (losartan / hydrochlorothiazide) is a combination medication that contains two first-choice options for lowering blood pressure. This medication is taken by mouth once daily. Like other blood pressure medications, Hyzaar (losartan / hydrochlorothiazide) can cause you to feel dizzy, especially when you first start this medication or when your provider raises your dose.

  • Indications of Ziac vs. Hyzaar

    Indications for
    •High blood pressure
    Indications for
    •High blood pressure
    •Lower the risk of stroke in people with high blood pressure and an enlarged left ventricle of the heart

  • Pros and Cons of Ziac vs. Hyzaar

    Pros and Const for Beta blocker / Diuretic (water pill)
    Pros
    •Only taken once daily
    •Combines two blood pressure medications into one tablet
    •Can take with or without food
    Cons
    •Comes in fixed dosage strengths, so it's harder to adjust the doses of the individual ingredients
    •Can make you urinate more often
    •Not a good option for people with a sulfa allergy
    Pros and Const for ARB / Diuretic (water pill) combo
    Pros
    •Contains two first-choice blood pressure medications
    •Convenient to take a combination of two medications in one pill taken just once a day
    •Protects your kidneys, which is especially useful for people with diabetes or mild-to-moderate kidney disease
    •Taken by mouth once per day
    Cons
    •Can make you urinate more often
    •Must be avoided in pregnant females
    •More difficult to customize the dose since Hyzaar (losartan / hydrochlorothiazide) is a combination of two medications
    •Only available as a tablet

  • Common Side Effects of Ziac vs. Hyzaar

    Common Side Effects for
    •Dizziness (5%)
    •Tiredness (5%)
    •Headache (5%)
    •Diarrhea (4%)
    Common Side Effects for
    •Upper respiratory tract infection (i.e., common cold; 6%)
    •Dizziness (6%)
    •Back pain (2%)

  • Warnings of Ziac vs. Hyzaar

    Common Side Effects for
    •Risk of heart problems after stopping Ziac (bisoprolol / hydrochlorothiazide) suddenly
    •Risk of heart failure
    •Changes in fluids and electrolytes in the body
    •Hidden symptoms of low blood sugar
    •Hidden symptoms of overactive thyroid
    •Caution use in people with breathing problems
    •Caution use in people with peripheral artery disease (PAD)
    •Risk of vision problems and glaucoma
    Common Side Effects for
    •Not for use during pregnancy
    •Low blood pressure
    •Kidney damage
    •Changes in electrolyte, blood sugar, and cholesterol levels
    •Vision problems
    •Lupus

  • Prices with our coupons for Ziac vs. Hyzaar

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    Learn more about Hyzaar

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