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Quinapril / HCTZ Coupon - Quinapril / HCTZ 10mg/12.5mg tablet

quinapril / HCTZ

Generic Accuretic
Used for Hypertension
Used for Hypertension

Accuretic (quinapril / hydrochlorothiazide or HCTZ) is used to treat high blood pressure in adults. It's a tablet that contains two types of blood pressure medications: an angiotensin-converting enzyme (ACE) inhibitor and a thiazide diuretic. This combination medication is taken by mouth once per day. The specific dosage depends on how high your blood pressure is and what blood pressure medications you've taken. Common side effects are headache and dizziness. This combination blood pressure medication is a lower-cost generic only; its brand name Accuretic is no longer available.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on September 8, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesImagesReferencesPricesMedicare
basics-icon

What is Accuretic (quinapril / hydrochlorothiazide)?

What is Accuretic (quinapril / hydrochlorothiazide) used for?

How Accuretic (quinapril / hydrochlorothiazide) works

Accuretic is a combination of two medications that work together to lower blood pressure.

Are you looking for information on quinapril or hydrochlorothiazide instead?

Drug Facts

Common BrandsAccuretic (brand name no longer available)
Drug ClassACE inhibitor / Diuretic (water pill)
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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$55.640
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What are the side effects of Accuretic (quinapril / hydrochlorothiazide)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (7%)
  • Dizziness (5%)
  • Cough (3%)
  • Fatigue or tiredness (3%)

Other Side Effects

  • Nausea or vomiting
  • Stomach pain
  • Indigestion
  • Muscle pain
  • Back pain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Angioedema (severe swelling): swelling of the face, lips, tongue, throat, arms, or legs
  • Severe allergic reaction: rash; trouble breathing; swelling of your lips, tongue, throat, or face
  • Dangerously low blood pressure: dizziness, lightheadedness, feeling faint, pale skin
  • Serious kidney problems: urinating less often than usual; swelling in your feet, ankles, or hands; unexplained weight gain
  • Liver problems: yellowing of the skin or eyes, stomach pain, nausea, vomiting, confusion

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Cough producing mucus

diarrhea

difficulty breathing

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

tightness in the chest

Rare

Black, tarry stools

bleeding gums

blistering, peeling, loosening of skin

blood in the urine or stools

blurred vision

confusion

decreased urination

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

fast or irregular heartbeat

increased sensitivity of skin to sunlight

muscle cramps or pain

numbness, tingling, pain, or weakness in the hands or feet

pinpoint red spots on the skin

rapid breathing

seizures

sunken eyes

sweating

thirst

trembling

unusual tiredness or weakness

weakness and heaviness of the legs

wrinkled skin

Incidence not known

Persistent non-healing sore

pink growth

reddish patch or irritated area

shiny bump

shock

speech problems

swelling of the hands, ankles, or feet

unusual bleeding or bruising

white, yellow or waxy scar-like area

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Headache

Less common

Back pain

coughing

lack or loss of strength

sleepiness or unusual drowsiness

trouble sleeping

Rare

Change in vision

constipation

discouragement

feeling sad or empty

general feeling of discomfort or illness

impaired vision

irritability

lack of appetite

loss of interest or pleasure

trouble concentrating

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Accuretic (quinapril / hydrochlorothiazide)

thumbs-up

Pros

Contains two first-choice medications for lowering blood pressure within a single pill

Taken by mouth once per day at any time of day

Available as a lower-cost generic

thumbs-down

Cons

Not available as a liquid

More difficult to customize the dose of each individual ingredient since it's a combination medication

Not safe to take while pregnant or breastfeeding

pharmacist-tips

Pharmacist tips for Accuretic (quinapril / hydrochlorothiazide)

pharmacist

  • Take Accuretic (quinapril / hydrochlorothiazide) with or without food at any time of day. If the medication hurts your stomach, taking it with food might help.

    • Be sure to check your blood pressure at home and write down your readings. Share this log with your prescriber at your follow-up visits. This will help your prescriber see how well Accuretic (quinapril / hydrochlorothiazide) is working for you and see whether you need any changes to your treatment plan.

      • Accuretic (quinapril / hydrochlorothiazide) can cause dizziness or headaches, especially when you first start taking the medication or when you change to a higher dose. These side effects should lessen as you continue taking the medication. Stand up slowly after sitting or lying down to prevent falls.

        • Dry cough is a well-known side effect of ACE-inhibitors like quinapril. You can have this cough at any time during treatment. Talk to your prescriber if you start having a cough while you're taking this medication and it gets annoying. Switching to a different blood pressure medication might help.

          • It's best to avoid alcohol or limit how much alcohol you drink when you're taking Accuretic (quinapril / hydrochlorothiazide). Alcohol can make blood pressure medications work less well because drinking alcohol regularly over a longer period of time can raise your blood pressure. Side effects like dizziness can also worsen if you drink alcohol with this medication.

            • Take Accuretic (quinapril / hydrochlorothiazide) exactly as instructed by your prescriber. Don't lower your dose or stop taking the medication suddenly without talking to your prescriber first. Otherwise, your blood pressure can go up really fast. Your prescriber might need to lower your dose slowly over time to prevent big changes to your blood pressure.

              faqs

              Frequently asked questions about Accuretic (quinapril / hydrochlorothiazide)

              Is Accuretic still available?
              The brand name Accuretic is discontinued and is no longer available. But the generic version, quinapril/hydrochlorothiazide, is still available.
              Is Accuretic the same as HCTZ?
              No. Accuretic is a combination blood pressure medication that contains hydrochlorothiazide or HCTZ and the ACE inhibitor quinapril. It's a tablet that contains these two medications in one. But both hydrochlorothiazide (HCTZ) and quinapril are also available by themselves.
              How long does it take for Accuretic (quinapril / hydrochlorothiazide) to work?
              Quinapril can start to lower your blood pressure within an hour, and hydrochlorothiazide can start to work after a few hours. Keep in mind that it can take up to 3 weeks to see the full blood pressure-lowering effect of Accuretic (quinapril / hydrochlorothiazide). It can also take some time before your prescriber finds a dose that works best for you, and they might need to adjust your dose depending on your blood pressure readings. Keep track of your blood pressure numbers and bring them to your appointments to help your healthcare team understand how well the medication is working for you.
              When should I take Accuretic (quinapril / hydrochlorothiazide)?
              You can take Accuretic (quinapril / hydrochlorothiazide) at any time of day. The blood pressure-lowering effects of the medication last for about 24 hours, so the most important thing is to take it consistently around the same time each day. You might consider taking Accuretic (quinapril / hydrochlorothiazide) in the morning or early afternoon because hydrochlorothiazide (a water pill) can make you urinate more often. To lessen the chance that you'll need to get up at night to use the bathroom often, try not to take the medication too close to bedtime. Talk with your care team if you have any questions about the best time to take Accuretic (quinapril / hydrochlorothiazide).
              Can Accuretic (quinapril / hydrochlorothiazide) cause liver damage?
              In clinical studies, liver damage wasn't a typical side effect that people who took Accuretic (quinapril / hydrochlorothiazide) reported having. But there are rare reports of people who took quinapril by itself and had a blockage in their bile duct, which can lead to liver problems and liver damage. Your prescriber might order blood tests to check your liver health. Contact your prescriber if you notice yellowing of your skin or whites of your eyes, nausea, or vomiting because these can be signs of liver damage. Your prescriber might adjust your Accuretic (quinapril / hydrochlorothiazide) dose or stop the medication if there's evidence that it's harming your liver.
              Is there a generic for Accuretic?
              Yes, Accuretic (quinapril / hydrochlorothiazide) is available as a lower-cost generic version. In fact, this combination medication is only available as a generic. The brand name Accuretic has been discontinued.
              Is it safe to take Accuretic (quinapril / hydrochlorothiazide) during pregnancy?
              No, Accuretic (quinapril / hydrochlorothiazide) isn't safe to taking during pregnancy. This medication can cause harm to unborn babies, including kidney damage and birth defects. Tell your precriber right away if you become pregnant you're while taking Accuretic (quinapril / hydrochlorothiazide). They can recommend safer treatment options to manage high blood pressure while you're pregnant.
              Can you breastfeed while you're taking Accuretic (quinapril / hydrochlorothiazide)?
              Ask your prescriber or your baby's primary care provider if you can breastfeeding while you're taking Accuretic (quinapril / hydrochlorothiazide). Both quinapril and hydrochlorothiazide can get into breast milk. It's not completely clear whether having these two medications in the milk is harmful to breastfed babies. To be safe, discuss with your prescriber or your baby's primary care provider about the risks and benefits of breastfeeding and taking Accuretic (quinapril / hydrochlorothiazide).
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              What are the risks and warnings for Accuretic (quinapril / hydrochlorothiazide)?

              Accuretic (quinapril / hydrochlorothiazide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Not safe during pregnancy

              The quinapril in this combination medication can cause severe and sometimes life-threatening harm to an unborn baby if it's taken during pregnancy. For this reason, you shouldn't take Accuretic (quinapril / hydrochlorothiazide) if you're pregnant. Stop taking this medication and tell your prescriber right away if you find out that you're pregnant. They'll recommend safer options to help lower your blood pressure. Discuss with your prescriber about these other options if you're thinking of becoming pregnant during treatment.

              risk-warning

              Angioedema (swelling)

              • Risk factors: Black people | Having angioedema in the past

                People who take medications that contain an ACE inhibitor like quinapril can experience a rare, but serious side effect called angioedema. This involves swelling in different parts of the body, including the face, throat, and tongue. Swelling of the tongue or throat area can be potentially life-threatening, since it can make it difficult to breathe.

                Angioedema can happen at any time while you're taking Accuretic (quinapril / hydrochlorothiazide). The risk for angioedema is higher for Black people than for people of other races and ethnicities. Get medical attention as soon as possible if you notice swelling in the face, lips, tongue, or throat; stomach pain; or difficulty breathing. You'll have to stop taking Accuretic (quinapril / hydrochlorothiazide) if this happens.

                risk-warning

                Low blood pressure

                • Risk factors: Not enough fluid in your body | Having diarrhea or vomiting for a long time | Low salt levels in your body | Taking high doses of diuretic medications

                  Sometimes, taking Accuretic (quinapril / hydrochlorothiazide) can cause your blood pressure to drop too much, especially when you stand up too fast. This can make you feel dizzy, tired, or lightheaded. This side effect is more common when you first start Accuretic (quinapril / hydrochlorothiazide) or when the dose is raised.

                  Make sure to stay well hydrated. Sit down slowly while you hold onto something if you feel dizzy. Get medical help right away if you fall and hit your head. Contact your prescriber if you feel too dizzy, lightheaded, tired, or confused while you're taking Accuretic (quinapril / hydrochlorothiazide).

                  risk-warning

                  Kidney damage

                  • Risk factors: Severe heart failure | Kidney problems | Not enough fluid in your body | Taking other medications that can cause kidney damage

                    Accuretic (quinapril / hydrochlorothiazide) can affect your kidneys and cause them to work less well. The risk is higher for people who have certain types of kidney problems, such as renal artery stenosis, and people who have very severe heart failure.

                    Your prescriber might order lab tests every so often to make sure your kidneys are healthy and working properly. Your prescriber might recommend that you stop taking Accuretic (quinapril / hydrochlorothiazide) if you develop kidney problems or if your kidney problems worsen during treatment. Tell your prescriber if you're urinating less often than usual, as this could be a sign that your kidneys aren't working as well.

                    risk-warning

                    Liver damage

                    Rarely, people who took ACE inhibitors like quinapril have developed a blocked bile duct. This condition can lead to liver problems or liver failure. Your prescriber might order blood tests to check your liver health from time to time. Let your care team know right away if you notice symptoms of liver problems, such as tiredness, stomach pain, or yellowing of your skin or whites of the eyes.

                    risk-warning

                    Changes in electrolyte, blood sugar, and cholesterol levels

                    Accuretic (quinapril / hydrochlorothiazide) can affect the level of certain electrolytes, like sodium, potassium, and magnesium, in your body. It can also cause changes in your blood sugar levels. In addition, this medication can raise the levels of cholesterol and triglycerides (a type of fat).

                    You might need blood work done every so often while you're taking Accuretic (quinapril / hydrochlorothiazide). These blood tests check that your electrolyte, blood sugar, and cholesterol levels are in a safe range. Let your care team know if you experience a fast heartbeat, weakness, low energy, muscle pain or cramps, less urination than usual, nausea, or vomiting. These can be signs of electrolyte changes in your body.

                    risk-warning

                    Vision problems

                    • Risk factors: Sulfa or penicillin allergies

                      Although rare, some people experience vision changes within hours or weeks after they start taking hydrochlorothiazide, which is found in this combination medication. Tell your optometrist or prescriber right away about any vision changes or eye pain and stop taking Accuretic (quinapril / hydrochlorothiazide) as soon as possible.

                      risk-warning

                      Lupus

                      • Risk factors: History of lupus

                        It's rare, but medications containing hydrochlorothiazide can cause or worsen lupus. Let your prescriber know if you have symptoms, such as feeling very tired, joint pain, or a rash across your cheeks and nose.

                        dosage

                        Accuretic (quinapril / hydrochlorothiazide) dosage forms

                        The average cost for 30 tablets of 10mg/12.5mg of Accuretic (quinapril / hydrochlorothiazide) is $455.93 with a free GoodRx coupon.0
                        tablet
                        Tablet
                        DosageQuantityPrice as low asPrice per unit
                        10mg/12.5mg90 tablets$455.93$5.07
                        20mg/12.5mg30 tablets$155.98$5.20
                        20mg/25mg30 tablets$155.98$5.20

                        Typical dosing for Accuretic (quinapril / hydrochlorothiazide)

                        Your prescriber will pick a starting dose based on factors like how high your blood pressure is, which other blood pressure medications you're currently taking or have recently taken, and how high your risk for side effects is.

                        In general, the typical dose ranges from 10 mg/12.5 mg (quinapril/hydrochlorothiazide) to 40 mg/25 mg (quinapril/hydrochlorothiazide) by mouth once daily.

                        interactions

                        Interactions between Accuretic (quinapril / hydrochlorothiazide) and other drugs

                        Accuretic (quinapril / hydrochlorothiazide) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Accuretic (quinapril / hydrochlorothiazide). Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                        How much does Accuretic (quinapril / hydrochlorothiazide) cost?

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                        contraindications-icon

                        Accuretic (quinapril / hydrochlorothiazide) contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Accuretic (quinapril / hydrochlorothiazide) will not be safe for you to take.
                        alternatives

                        What are alternatives to Accuretic (quinapril / hydrochlorothiazide)?

                        There are a number of medications that your doctor can prescribe in place of Accuretic (quinapril / hydrochlorothiazide). Compare a few possible alternatives below.
                        Accuretic (quinapril / hydrochlorothiazide)
                        Used for:
                        $55.64 Lowest GoodRx priceView Prices
                        Zestoretic (lisinopril / hydrochlorothiazide)
                        Used for:
                        $11.15 Lowest GoodRx priceView Prices
                        Lotensin HCT (benazepril / hydrochlorothiazide)
                        Used for:
                        $29.85 Lowest GoodRx priceView Prices
                        images

                        Accuretic (quinapril / hydrochlorothiazide) images

                        Pink Round M 542 - Quinapril Hydrochloride / Hydrochlorothiazide 10mg-12.5mg Tablet
                        This medicine is Pink, Round, Scored Tablet Imprinted With "M 542".Pink Round M 542 - Quinapril Hydrochloride / Hydrochlorothiazide 10mg-12.5mg Tablet
                        Pink Oval G 222 - Quinapril Hydrochloride / Hydrochlorothiazide 10mg-12.5mg Tablet
                        This medicine is Pink, Oval, Scored Tablet Imprinted With "G 222".Pink Oval G 222 - Quinapril Hydrochloride / Hydrochlorothiazide 10mg-12.5mg Tablet
                        Peach Oval Ce 153 - Quinapril Hydrochloride / Hydrochlorothiazide 10mg-12.5mg Tablet
                        This medicine is Peach, Oval, Scored Tablet Imprinted With "Ce 153".Peach Oval Ce 153 - Quinapril Hydrochloride / Hydrochlorothiazide 10mg-12.5mg Tablet

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                        References

                        Best studies we found

                        Coucke, E. M., et al. (2022). Biliary obstruction. StatPearls.

                        Drugs@FDA: FDA-Approved Drugs. (n.d.). Accuretic. U.S. Food and Drug Administration.

                        Flack, J. M., et al. (2020). Blood pressure and the new ACC/AHA hypertension guidelines. Trends in Cardiovascular Medicine.

                        View All References (3)

                        Lupin Pharmaceuticals, Inc. (2024). Quinapril HCl and hydrochlorothiazide tablet [package insert]. DailyMed.

                        National Institute of Diabetes and Digestive and Kidney Diseases. (2014). Renal artery stenosis.

                        National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Quinapril. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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