Thiazide-like diuretics are used to treat high blood pressure, heart failure, and edema (swelling due to fluid retention). They also have other uses, such as managing certain kidney disorders. These medications work by helping your kidneys remove extra salt and water from your body, which helps to lower blood pressure and reduce swelling. Thiazide-like diuretics are usually taken as oral pills. Examples include chlorthalidone (Thalitone), indapamide , and metolazone (Zaroxolyn).