Furosemide (Lasix) and eplerenone (Inspra) are both medications used to treat high blood pressure, but they belong to different medication classes. Furosemide is a loop diuretic, often called a water pill, that helps your body get rid of extra fluid and electrolytes, which can also help with swelling. Eplerenone, on the other hand, is an aldosterone receptor antagonist that works by blocking a hormone that raises blood pressure, helping your body remove extra salt and water. Furosemide is available as a generic and comes in tablet and oral solution forms, while eplerenone is available as a generic tablet. Furosemide is typically taken once or twice daily, while eplerenone is usually taken once daily. Common side effects of furosemide include increased urination and dizziness, while eplerenone can cause digestive issues and high potassium levels. Furosemide can interact with medications like corticosteroids, while eplerenone can interact with ACE inhibitors and NSAIDs. Both medications require careful monitoring, but they have different risks and benefits based on your health needs.