provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Eplerenone Coupon - Eplerenone 25mg tablet

eplerenone

Generic Inspra
Used for Heart Failure, Hypertension
Used for Heart Failure, Hypertension

Eplerenone (Inspra) is a medication that’s used to treat high blood pressure and improve survival among people with heart failure after a heart attack. It comes as an oral tablet that can be taken alone or in combination with other medications. Look out for side effects including dizziness, nausea, cough, and shortness of breath. Eplerenone (Inspra) is available as a generic tablet and also under the brand name Inspra.

basics-icon

What is Eplerenone (Inspra)?

What is Eplerenone (Inspra) used for?

  • Heart failure after a heart attack

  • High blood pressure

How Eplerenone (Inspra) works

Eplerenone (Inspra) is a mineralocorticoid (aldosterone) antagonist. Aldosterone is a natural hormone in the body that normally raises your blood pressure by increasing the amount of salt and water in your bloodstream. So by blocking aldosterone, eplerenone (Inspra) helps your body get rid of extra salt and water, which then lowers your blood pressure.

It’s unclear how exactly eplerenone (Inspra) helps with heart failure. But it’s thought that the medication helps protect the heart. This will help reduce the risk of death in people with heart failure.

Drug Facts

Common BrandsInspra
Drug ClassAldosterone receptor antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$114.52(save 84.28%)
GoodRx discount
$18.00
See prices
basics-icon

What are the side effects of Eplerenone (Inspra)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Digestive system problems (20%)
  • Nervous system problems (15%)
  • Urinary tract problems (14%)
  • Shortness of breath (7%)
  • Skin problems (7%)
  • Mental health problems (7%)
  • Cough (5%)

Other Side Effects

  • Headache
  • Dizziness
  • Chest pain or heart attack
  • Enlargement of male breasts (gynecomastia)
  • Abnormal vaginal bleeding

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • High potassium (hyperkalemia): irregular heart beat, nausea, muscle pain and weakness, numbness and tingling

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Excess of cholesterol in the blood

excess of triglycerides in the blood

Incidence not known

Abdominal or stomach pain

arm, back, or jaw pain

chest pain or discomfort

chest tightness or heaviness

confusion

difficulty with breathing

dizziness

fast or irregular heartbeat

headache

irregular heartbeat

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

nausea

nervousness

numbness or tingling in the hands, feet, or lips

pain or discomfort in the arms, jaw, back, or neck

rash

shortness of breath

sweating

vomiting

weakness or heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Abnormal vaginal bleeding

breast pain

chills

cloudy urine

cough

diarrhea

fever

general feeling of discomfort or illness

joint pain

loss of appetite

muscle aches and pains

swelling of the breasts or breast soreness in both females and males

unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Eplerenone (Inspra)

thumbs-up

Pros

Improves survival for people with heart failure after a heart attack

Fewer side effects than spironolactone

Typically once daily dosing

thumbs-down

Cons

Have to get regular blood tests while taking the medication to check for high potassium levels

Not safe to use with severe kidney problems

Isn’t a first-choice medication for high blood pressure or heart failure

pharmacist-tips

Pharmacist tips for Eplerenone (Inspra)

pharmacist
  • Eplerenone (Inspra) can be taken with or without food, and it’s best to take it around the same time every day.

    • Following a low sodium diet while using eplerenone (Inspra) is a good option to help lower blood pressure. If you’re using salt substitutes, be sure to choose salt substitutes that don’t have potassium to lower the chance of having high potassium levels with eplerenone (Inspra). Also, don’t use any potassium supplements while taking this medication since this can also lead to high potassium levels

      • To prevent high potassium levels, you’ll need regular blood work to check your potassium levels while taking eplerenone (Inspra). Typically, you’ll get blood work done before starting this medication, within the first week, at one month, or whenever the dose is changed. If you start taking certain medications (e.g., ACE inhibitors, ARBS, or NSAIDs) you’ll also need to have your potassium and creatinine levels checked within 1 week.

        • When eplerenone (Inspra) is used in combination with certain blood pressure medications (e.g., ACE inhibitors, ARBs, and NSAIDs), there is a greater risk for high levels of potassium in your blood. So it’s important to tell your healthcare provider if you’re also taking any of these medications.

          • Though rare, eplerenone (Inspra) can cause an increase in breast tenderness and size in men. If this becomes bothersome, speak to your healthcare provider.

            • Eplerenone (Inspra) doesn’t work immediately. In fact, you might notice a drop in your blood pressure in as soon as 2 weeks. But it does take about 4 weeks to see the full effect of this medication. So it’s important to keep taking this medication even if you don’t feel any changes. You might want to monitor your blood pressure at home while using this medication.

              faqs

              Frequently asked questions about Eplerenone (Inspra)

              Does eplerenone (Inspra) cause enlargement of breast tissue in men (gynecomastia)?
              Possibly, but gynecomastia is pretty rare with eplerenone (Inspra). In studies, it was reported in about 0.5% of men taking the medication. Gynecomastia is a condition in men where breast tissue increases in size. While not life threatening, it can be an unwanted side effect. But risk for this side effect is much lower with eplerenone (Inspra) than with other similar medications, such as spironolactone (Aldactone). Typically, if someone experiences gynecomastia with spironolactone, their healthcare provider will switch them to eplerenone (Inspra). If you experience breast tenderness or swelling of the breast tissue while taking eplerenone (Inspra), contact your healthcare provider to determine the best course of action.
              What’s the difference between eplerenone (Inspra) and spironolactone (Aldactone)?
              Spironolactone (Aldactone), like eplerenone (Inspra), is also an aldosterone antagonist that’s used to lower blood pressure and increase survival in people with heart failure. But eplerenone (Inspra) is associated with fewer hormone-related side effects, like gynecomastia, low sex drive, and changes in menstruation. So eplerenone (Inspra) is often recommended if people are unable to tolerate some side effects of spironolactone. Also, eplerenone (Inspra) interacts with more medications when compared to spironolactone (Aldactone), so make sure that you tell your healthcare provider what medications you take. Talk with your healthcare provider if you have questions about either medication.
              Does eplerenone (Inspra) cause weight gain?
              In studies, weight gain wasn’t reported as a side effect in people taking eplerenone (Inspra). But it doesn’t mean that it can’t happen to you. If you notice weight gain or swelling in your legs or other parts of the body, contact your healthcare provider to determine the next best steps for you.
              Does eplerenone (Inspra) cause kidney problems?
              It's unclear whether or not eplerenone (Inspra) causes kidney problems on its own. Studies showed that some people who took eplerenone (Inspra) experienced an increase in the level of creatinine in the blood, which can suggest kidney damage or kidney problems. But these people also had other risk factors for higher creatinine levels, so it's unclear whether the increase is caused by eplerenone (Inspra) or something else. If you have kidney problems, talk with your provider. Eplerenone (Inspra) isn't recommended for people with serious kidney problems. In addition, it can cause high potassium levels, which can be made worse with kidney problems.
              Is eplerenone (Inspra) a beta blocker?
              No. Although beta blockers are also used to lower blood pressure, and in some instances treat heart failure, eplerenone (Inspra) isn't a beta blocker. Instead it’s an aldosterone antagonist that works to help the body remove sodium and water through the kidneys. Beta blockers, such as carvedilol (Coreg) or metoprolol (Lopressor), work by slowing the heart rate and relaxing the blood vessels. Talk to your provider to determine which medication is best for you.
              Is eplerenone (Inspra) safe in pregnancy?
              Maybe. There isn't enough information to know if eplerenone (Inspra) is completely safe to use while pregnant. In animal studies, there weren’t any birth defects reported when using this medication. But that doesn’t mean that there is no risk to an unborn child while taking eplerenone (Inspra). Before taking eplerenone (Inspra), let your provider know if you’re pregnant or thinking about becoming pregnant.
              Can I use eplerenone (Inspra) by itself to treat high blood pressure?
              Yes. But eplerenone (Inspra) alone isn’t a first-choice treatment option for treating high blood pressure. Instead, it’s normally used along with other blood pressure medications like angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARB), calcium channel blockers, beta blockers, and hydrochlorothiazide.
              GoodRxEducationalIcon

              How to save using GoodRx

              Compare Prices
              1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
              Select your free coupon
              2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
              Show coupon to your pharmacist
              3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
              Get free couponLearn more
              warings-icon

              What are the risks and warnings for Eplerenone (Inspra)?

              Eplerenone (Inspra) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              High potassium (hyperkalemia)

              • Risk factors: Current kidney problems | Diabetes | Taking other medications that can increase potassium | Taking other medications that interact with eplerenone (Inspra)

                Eplerenone (Inspra) can cause high potassium levels in the blood. Very high potassium levels can cause changes in heart rhythm. In emergency situations, it can cause the heart to stop beating. Your risk is higher if you have kidney problems, have diabetes, or are taking other medications that interact with eplerenone (Inspra) (e.g., ACE inhibitors, ARBs, NSAIDs). It’s important to report any sudden changes in numbness or tingling, nausea, or muscle weakness. If this is something that you experience, call your healthcare provider to let them know, they might suggest lowering your dose.

                dosage

                Eplerenone (Inspra) dosage forms

                The average cost for 30 tablets of 25mg of Eplerenone (Inspra) is $18.00 with a free GoodRx coupon. This is 84.28% off the average retail price of $114.52.
                tablet
                Tablet
                DosageQuantityPrice as low asPrice per unit
                25mg30 tablets$18.00$0.60
                50mg90 tablets$41.00$0.46

                Typical dosing for Eplerenone (Inspra)

                • Heart failure after a heart attack: The typical starting dose is 25 mg by mouth once daily. The max dose is 50 mg by mouth once daily.

                • High blood pressure: The typical starting dose is 50 mg by mouth once daily. The max dose is 50 mg by mouth twice a day.

                Your dose might differ depending on your potassium levels and if you’re also taking other medications such as amiodarone (Pacerone), fluconazole (Diflucan), diltiazem (Cardizem), or verapamil.

                interactions

                Interactions between Eplerenone (Inspra) and other drugs

                Eplerenone (Inspra) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Eplerenone (Inspra). Please note that only the generic name of each medication is listed below.

                Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                • Licorice
                drug-cost

                How much does Eplerenone (Inspra) cost?

                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                contraindications-icon

                Eplerenone (Inspra) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Eplerenone (Inspra) will not be safe for you to take.

                For all people:

                For people with high blood pressure:

                alternatives

                What are alternatives to Eplerenone (Inspra)?

                There are a number of medications that your doctor can prescribe in place of Eplerenone (Inspra). Compare a few possible alternatives below.
                Eplerenone (Inspra)
                Used for:
                • Heart failure after a heart attack

                • High blood pressure

                $18.00 Lowest GoodRx priceView Prices
                Used for:
                $5.40 Lowest GoodRx priceView Prices
                Used for:
                $17.86 Lowest GoodRx priceView Prices
                images

                Eplerenone (Inspra) images

                White Round Sz And 12 - Eplerenone 25mg Tablet
                This medicine is White, Round Tablet Imprinted With "12" And "Sz".White Round Sz And 12 - Eplerenone 25mg Tablet
                Yellow Round 68 And V - Eplerenone 25mg Tablet
                This medicine is Yellow, Round Tablet Imprinted With "68" And "V".Yellow Round 68 And V - Eplerenone 25mg Tablet
                Yellow Round 68 And V - Eplerenone 25mg Tablet
                This medicine is Yellow, Round Tablet Imprinted With "68" And "V".Yellow Round 68 And V - Eplerenone 25mg Tablet
                Yellow Diamond G And 25Mg - Eplerenone 25mg Tablet
                This medicine is Yellow, Diamond Tablet Imprinted With "25Mg" And "G".Yellow Diamond G And 25Mg - Eplerenone 25mg Tablet

                Get savings updates for Eplerenone (Inspra)

                Receive price alerts, news, and other messages from GoodRx about Eplerenone (Inspra) and other healthcare topics and relevant savings offers.

                By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                References

                Best studies we found
                View All References (6)

                Kartha Pharmaceuticals, Inc. (2022). Eplerenone tablet, film coated [package insert]. DailyMed.

                National Kidney Foundation. (n.d.). Albuminuria (proteinuria).

                National Kidney Foundation. (n.d.). Creatinine.

                Pitt, B., et al. (2003). Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. The New England Journal of Medicine.

                Rubenfire, M. (2018). 2017 guideline for high blood pressure in adults. American College of Cardiology.

                Unger, T., et al. (2020). 2020 International Society of Hypertension global hypertension practice guidelines. Hypertension.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                Was this page helpful?

                Browse medications

                View All

                Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.